ATP promotes NCX-reversal in aortic smooth muscle cells by DAG-activated Na + entry

Reversal of the plasma membrane Na +/Ca 2+ exchanger (NCX) has been shown to mediate Ca 2+ influx in response to activation of G-protein linked receptors. Functional coupling of reverse-mode NCX with canonical transient receptor potential channels (TRPC), specifically TRPC6, has recently been demons...

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Veröffentlicht in:	Biochemical and biophysical research communications 2007-06, Vol.357 (4), p.1177-1182
Hauptverfasser:	Syyong, Harley T., Poburko, Damon, Fameli, Nicola, Breemen, Cornelis van
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - administration & dosage Aequorin Animals Aorta - drug effects Aorta - metabolism Calcium - metabolism Cells, Cultured Dose-Response Relationship, Drug Microdomains Mitochondria Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Na + entry Na +/Ca 2+ exchanger Rats Sarcoplasmic reticulum Smooth muscle cells Sodium - metabolism Sodium-Calcium Exchanger - metabolism TRPC6
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