17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites

The question addressed in this study was the nature of the enzyme required to remove the side-chain of 17-hydroxycorticosteroids, leading in the case of cortisol to the excretion of 11β-hydroxyandrosterone, 11-oxo-androsterone and the corresponding etiocholanolones. We questioned whether it could be...

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Veröffentlicht in:	Steroids 2008-07, Vol.73 (6), p.652-656
Hauptverfasser:	Shackleton, Cedric H.L., Neres, Marcos S., Hughes, Beverly A., Stewart, Paul M., Kater, Claudio E.
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxylase deficiency Adrenal Hyperplasia, Congenital - enzymology Biological and medical sciences C17,20-lyase Fundamental and applied biological sciences. Psychology Humans Hydrocortisone - metabolism Hydrolysis Steroid 17-alpha-Hydroxylase - metabolism Steroid metabolism Urinary steroids Vertebrates: endocrinology
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