Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling

IL-7Ralpha is essential for the development and homeostatic maintenance of mature T cells. Studies in humans and mice have shown that IL-7Ralpha expression is reduced by its cognate cytokine, IL-7, and Ag, suggesting that active regulation of IL-7 responsiveness is necessary to balance T cell number...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-04, Vol.180 (8), p.5201-5210
Hauptverfasser:	Alves, Nuno L, van Leeuwen, Ester M M, Derks, Ingrid A M, van Lier, René A W
Format:	Artikel
Sprache:	eng
Schlagworte:	CD28 Antigens - immunology CD28 Antigens - metabolism Cytokines - immunology Cytokines - metabolism Cytomegalovirus Down-Regulation Humans Interleukin-7 - immunology Interleukin-7 - metabolism Jurkat Cells Lymphocyte Activation Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Receptors, Interleukin-7 - immunology Receptors, Interleukin-7 - metabolism Signal Transduction T-Lymphocytes - immunology T-Lymphocytes - metabolism
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