New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma
The concept of mesenchymal fibroblasts has evolved over the past two decades from a relatively inert structural cell type to a dynamic, pluripotent cell lineage controlling normal connective tissue formation, homeostasis, and repair and as principle players in pathogenic scarring and fibrosis. In wo...
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Veröffentlicht in: | Current rheumatology reports 2007-05, Vol.9 (2), p.136-143 |
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creator | Abraham, David J Eckes, Beate Rajkumar, Vineeth Krieg, Thomas |
description | The concept of mesenchymal fibroblasts has evolved over the past two decades from a relatively inert structural cell type to a dynamic, pluripotent cell lineage controlling normal connective tissue formation, homeostasis, and repair and as principle players in pathogenic scarring and fibrosis. In wound healing and tissue repair, fibroblasts provide proinflammatory signals and synthesize interstitial collagens, fibronectins, and other matrix components to repair the damaged tissue. Fibroblasts can differentiate into the myofibroblast, a specialized contractile cell type responsible for wound closure, tissue contraction, and scarring. This article reviews our current understanding of the origins of mesenchymal cells and their role in excessive scarring and fibrogenesis and in the systemic fibrotic disease scleroderma. |
doi_str_mv | 10.1007/s11926-007-0008-z |
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This article reviews our current understanding of the origins of mesenchymal cells and their role in excessive scarring and fibrogenesis and in the systemic fibrotic disease scleroderma.</description><subject>Cell Differentiation</subject><subject>Fibroblasts - pathology</subject><subject>Fibrosis - pathology</subject><subject>Humans</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Scleroderma, Systemic - etiology</subject><subject>Scleroderma, Systemic - pathology</subject><subject>Signal Transduction</subject><issn>1523-3774</issn><issn>1534-6307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE9LxDAQxYMo7rr6AbxIT96qk6RtGm-y-A8Wvei5pOlEImlTk66y--lt3QU9DPMY3nsMP0LOKVxRAHEdKZWsSEc5DpTp9oDMac6ztOAgDifNeMqFyGbkJMYPADa6-DGZUZGPOsvmRD_jd9LgFzrft9gNMbFdYmwdfO1UHBLVNUm78f8utfXOv29uEtv2zmo1WN_FxPiwi0Ubf0NROwy-wdCqU3JklIt4tt8L8nZ_97p8TFcvD0_L21WqWQlDWtLSQK0BZKMFNhmXSkKpDRMmq0vKtOCSI1O6KIxRWmMuFKDMtUTImQa-IJe73j74zzXGoWpt1Oic6tCvYyUgK0UBcjTSnVGP_8aApuqDbVXYVBSqiWy1I1tNciJbbcfMxb58XbfY_CX2KPkP_K520w</recordid><startdate>200705</startdate><enddate>200705</enddate><creator>Abraham, David J</creator><creator>Eckes, Beate</creator><creator>Rajkumar, Vineeth</creator><creator>Krieg, Thomas</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200705</creationdate><title>New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma</title><author>Abraham, David J ; Eckes, Beate ; Rajkumar, Vineeth ; Krieg, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c280t-818f0bc009dc7ed439a908cf27f4b812c7393e2ac66ffacce57a0e95c9e052c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Cell Differentiation</topic><topic>Fibroblasts - pathology</topic><topic>Fibrosis - pathology</topic><topic>Humans</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Scleroderma, Systemic - etiology</topic><topic>Scleroderma, Systemic - pathology</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abraham, David J</creatorcontrib><creatorcontrib>Eckes, Beate</creatorcontrib><creatorcontrib>Rajkumar, Vineeth</creatorcontrib><creatorcontrib>Krieg, Thomas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current rheumatology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abraham, David J</au><au>Eckes, Beate</au><au>Rajkumar, Vineeth</au><au>Krieg, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma</atitle><jtitle>Current rheumatology reports</jtitle><addtitle>Curr Rheumatol Rep</addtitle><date>2007-05</date><risdate>2007</risdate><volume>9</volume><issue>2</issue><spage>136</spage><epage>143</epage><pages>136-143</pages><issn>1523-3774</issn><eissn>1534-6307</eissn><abstract>The concept of mesenchymal fibroblasts has evolved over the past two decades from a relatively inert structural cell type to a dynamic, pluripotent cell lineage controlling normal connective tissue formation, homeostasis, and repair and as principle players in pathogenic scarring and fibrosis. 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subjects | Cell Differentiation Fibroblasts - pathology Fibrosis - pathology Humans Mesenchymal Stromal Cells - cytology Scleroderma, Systemic - etiology Scleroderma, Systemic - pathology Signal Transduction |
title | New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma |
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