Direct effects of apelin on cardiomyocyte contractility and electrophysiology

Apelin, the ligand for the angiotensin receptor like-1, has been implicated in the pathogenesis of atrial fibrillation and heart failure. However, it is unknown if apelin has direct effects on cardiomyocyte contractility and electrophysiology. APJ-like immunoreactivity was localized to T-tubules and...

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Veröffentlicht in:	Biochemical and biophysical research communications 2007-06, Vol.357 (4), p.889-895
Hauptverfasser:	Farkasfalvi, Klára, Stagg, Mark A., Coppen, Steven R., Siedlecka, Urszula, Lee, Joon, Soppa, Gopal K., Marczin, Nándor, Szokodi, István, Yacoub, Magdi H., Terracciano, Cesare M.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Animals Apelin Calcium - metabolism Carrier Proteins - administration & dosage Cell communication Cells, Cultured Dose-Response Relationship, Drug Inotropic agents Intercellular Signaling Peptides and Proteins Myocardial Contraction - drug effects Myocardial Contraction - physiology Myocytes Myocytes, Cardiac - drug effects Myocytes, Cardiac - physiology Na +/H + exchanger Peptide hormones Rats Sodium-Hydrogen Exchangers - metabolism
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