Recent applications of Chemical Imaging to pharmaceutical process monitoring and quality control
Chemical Imaging (CI) is an emerging platform technology that integrates conventional imaging and spectroscopy to attain both spatial and spectral information from an object. Vibrational spectroscopic methods, such as Near Infrared (NIR) and Raman spectroscopy, combined with imaging are particularly...
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| Veröffentlicht in: | European journal of pharmaceutics and biopharmaceutics 2008-05, Vol.69 (1), p.10-22 |
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| container_title | European journal of pharmaceutics and biopharmaceutics |
| container_volume | 69 |
| creator | Gowen, A.A. O’Donnell, C.P. Cullen, P.J. Bell, S.E.J. |
| description | Chemical Imaging (CI) is an emerging platform technology that integrates conventional imaging and spectroscopy to attain both spatial and spectral information from an object. Vibrational spectroscopic methods, such as Near Infrared (NIR) and Raman spectroscopy, combined with imaging are particularly useful for analysis of biological/pharmaceutical forms. The rapid, non-destructive and non-invasive features of CI mark its potential suitability as a process analytical tool for the pharmaceutical industry, for both process monitoring and quality control in the many stages of drug production. This paper provides an overview of CI principles, instrumentation and analysis. Recent applications of Raman and NIR-CI to pharmaceutical quality and process control are presented; challenges facing CI implementation and likely future developments in the technology are also discussed. |
| doi_str_mv | 10.1016/j.ejpb.2007.10.013 |
| format | Article |
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Vibrational spectroscopic methods, such as Near Infrared (NIR) and Raman spectroscopy, combined with imaging are particularly useful for analysis of biological/pharmaceutical forms. The rapid, non-destructive and non-invasive features of CI mark its potential suitability as a process analytical tool for the pharmaceutical industry, for both process monitoring and quality control in the many stages of drug production. This paper provides an overview of CI principles, instrumentation and analysis. 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Vibrational spectroscopic methods, such as Near Infrared (NIR) and Raman spectroscopy, combined with imaging are particularly useful for analysis of biological/pharmaceutical forms. The rapid, non-destructive and non-invasive features of CI mark its potential suitability as a process analytical tool for the pharmaceutical industry, for both process monitoring and quality control in the many stages of drug production. This paper provides an overview of CI principles, instrumentation and analysis. Recent applications of Raman and NIR-CI to pharmaceutical quality and process control are presented; challenges facing CI implementation and likely future developments in the technology are also discussed.</description><subject>Biological and medical sciences</subject><subject>Chemical Imaging</subject><subject>Chemistry, Pharmaceutical - instrumentation</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Drug</subject><subject>Drug Compounding - instrumentation</subject><subject>Drug Compounding - methods</subject><subject>Drug Design</subject><subject>Equipment Design</subject><subject>General pharmacology</subject><subject>Image Processing, Computer-Assisted</subject><subject>Medical sciences</subject><subject>NIR</subject><subject>Non-destructive</subject><subject>Pharmaceutical</subject><subject>Pharmaceutical Preparations</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Pharmacy - methods</subject><subject>Pharmacy - standards</subject><subject>Quality Control</subject><subject>Raman</subject><subject>Software</subject><subject>Spectroscopy, Near-Infrared - methods</subject><subject>Spectrum Analysis, Raman - methods</subject><subject>Tablets</subject><subject>Technology, Pharmaceutical - instrumentation</subject><subject>Technology, Pharmaceutical - methods</subject><issn>0939-6411</issn><issn>1873-3441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EotvCH-CAfIFblvFHbEfiglZAK1VCQr0bx3FarxI7tZ1K_fc47ApunEYz88zo1YPQOwJ7AkR8Ou7dcen3FEDWwR4Ie4F2REnWMM7JS7SDjnWN4IRcoMucjwDAZateowuiiOAdFTv066ezLhRslmXy1hQfQ8ZxxIcHN9d-wjezuffhHpeIlweTZmPdWv5slhStyxnPMfgS0waZMODH1Uy-PGMbQ0lxeoNejWbK7u25XqG7b1_vDtfN7Y_vN4cvt43lHS-Ngb7rFOOCtX1bs4FhUnWWcqYGCsPQ9tIIQ6QllBE1qn5UwMTIOLROCMKu0MfT25rqcXW56Nln66bJBBfXrCVwJQFoBekJtCnmnNyol-Rnk541Ab1p1Ue9adWb1m1Wtdaj9-fvaz-74d_J2WMFPpwBk6ubMZlgff7LUaCSECEr9_nEuariybuks_UuWDf45GzRQ_T_y_EbGGKV_w</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Gowen, A.A.</creator><creator>O’Donnell, C.P.</creator><creator>Cullen, P.J.</creator><creator>Bell, S.E.J.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080501</creationdate><title>Recent applications of Chemical Imaging to pharmaceutical process monitoring and quality control</title><author>Gowen, A.A. ; O’Donnell, C.P. ; Cullen, P.J. ; Bell, S.E.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-a0b99834635b56490a3789c2438d20dd5b7a6a17c12318f8bf8036f3405e6613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Chemical Imaging</topic><topic>Chemistry, Pharmaceutical - instrumentation</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Drug</topic><topic>Drug Compounding - instrumentation</topic><topic>Drug Compounding - methods</topic><topic>Drug Design</topic><topic>Equipment Design</topic><topic>General pharmacology</topic><topic>Image Processing, Computer-Assisted</topic><topic>Medical sciences</topic><topic>NIR</topic><topic>Non-destructive</topic><topic>Pharmaceutical</topic><topic>Pharmaceutical Preparations</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Pharmacy - methods</topic><topic>Pharmacy - standards</topic><topic>Quality Control</topic><topic>Raman</topic><topic>Software</topic><topic>Spectroscopy, Near-Infrared - methods</topic><topic>Spectrum Analysis, Raman - methods</topic><topic>Tablets</topic><topic>Technology, Pharmaceutical - instrumentation</topic><topic>Technology, Pharmaceutical - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gowen, A.A.</creatorcontrib><creatorcontrib>O’Donnell, C.P.</creatorcontrib><creatorcontrib>Cullen, P.J.</creatorcontrib><creatorcontrib>Bell, S.E.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gowen, A.A.</au><au>O’Donnell, C.P.</au><au>Cullen, P.J.</au><au>Bell, S.E.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent applications of Chemical Imaging to pharmaceutical process monitoring and quality control</atitle><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle><addtitle>Eur J Pharm Biopharm</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>69</volume><issue>1</issue><spage>10</spage><epage>22</epage><pages>10-22</pages><issn>0939-6411</issn><eissn>1873-3441</eissn><abstract>Chemical Imaging (CI) is an emerging platform technology that integrates conventional imaging and spectroscopy to attain both spatial and spectral information from an object. 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| identifier | ISSN: 0939-6411 |
| ispartof | European journal of pharmaceutics and biopharmaceutics, 2008-05, Vol.69 (1), p.10-22 |
| issn | 0939-6411 1873-3441 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences Chemical Imaging Chemistry, Pharmaceutical - instrumentation Chemistry, Pharmaceutical - methods Drug Drug Compounding - instrumentation Drug Compounding - methods Drug Design Equipment Design General pharmacology Image Processing, Computer-Assisted Medical sciences NIR Non-destructive Pharmaceutical Pharmaceutical Preparations Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pharmacy - methods Pharmacy - standards Quality Control Raman Software Spectroscopy, Near-Infrared - methods Spectrum Analysis, Raman - methods Tablets Technology, Pharmaceutical - instrumentation Technology, Pharmaceutical - methods |
| title | Recent applications of Chemical Imaging to pharmaceutical process monitoring and quality control |
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