The addition of a new immunomodulator with the adjuvant adaptation ADAD system using fatty acid binding proteins increases the protection against Fasciola hepatica
Fatty acid binding proteins (FABP) have shown protective immune response against Fasciola hepatica infection. We evaluated the protection induced by the Fh12 FABP from F. hepatica (Fh12) combined with the new immunomodulator the lipidic aminoalcohol OA0012 in the ADAD system in mice and sheep. In th...
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| Veröffentlicht in: | Veterinary parasitology 2008-05, Vol.153 (1), p.176-181 |
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| creator | López-Abán, J. Nogal-Ruiz, J.J. Vicente, B. Morrondo, P. Diez-Baños, P. Hillyer, G.V. Martínez-Fernández, A.R. Feliciano, A. San Muro, A. |
| description | Fatty acid binding proteins (FABP) have shown protective immune response against
Fasciola hepatica infection. We evaluated the protection induced by the Fh12 FABP from
F. hepatica (Fh12) combined with the new immunomodulator the lipidic aminoalcohol OA0012 in the ADAD system in mice and sheep. In this work we introduced a lipidic aminoalcohol OA0012 as immunomodulator alone or in combination with the hydroalcoholic extract of
Phlebodium pseudoaureum; PAL. Mice vaccinated with ADAD containing OA0012
+
Fh12 or OA0012
+
Qs
+
Fh12 had survival rates of 40–50%. Sheep ADAD-vaccinated with OA0012
+
Qs
+
Fh12 showed lower fluke recovery, less hepatic lesions and higher post-infection daily weight gain than
F. hepatica infected control animals. Sheep ADAD-vaccinated with OA0012 combined PAL and Qs
+
Fh12 showed lower fluke recovery (42%), lower adult worms count (57%) lower faecal egg count (38%), less hepatic lesions and higher post-infection daily weight gain than
F. hepatica infected control animals. Thus, the addition of a new immunomodulator of synthesis to ADAD system with FABPs increased the protection against
F. hepatica. |
| doi_str_mv | 10.1016/j.vetpar.2008.01.023 |
| format | Article |
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Fasciola hepatica infection. We evaluated the protection induced by the Fh12 FABP from
F. hepatica (Fh12) combined with the new immunomodulator the lipidic aminoalcohol OA0012 in the ADAD system in mice and sheep. In this work we introduced a lipidic aminoalcohol OA0012 as immunomodulator alone or in combination with the hydroalcoholic extract of
Phlebodium pseudoaureum; PAL. Mice vaccinated with ADAD containing OA0012
+
Fh12 or OA0012
+
Qs
+
Fh12 had survival rates of 40–50%. Sheep ADAD-vaccinated with OA0012
+
Qs
+
Fh12 showed lower fluke recovery, less hepatic lesions and higher post-infection daily weight gain than
F. hepatica infected control animals. Sheep ADAD-vaccinated with OA0012 combined PAL and Qs
+
Fh12 showed lower fluke recovery (42%), lower adult worms count (57%) lower faecal egg count (38%), less hepatic lesions and higher post-infection daily weight gain than
F. hepatica infected control animals. Thus, the addition of a new immunomodulator of synthesis to ADAD system with FABPs increased the protection against
F. hepatica.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/j.vetpar.2008.01.023</identifier><identifier>PMID: 18308471</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>ADAD system ; Adjuvants, Immunologic - administration & dosage ; Animals ; Antibodies, Helminth - blood ; Antibodies, Helminth - immunology ; disease control ; FABP ; Fasciola hepatica ; Fasciola hepatica - immunology ; Fascioliasis - prevention & control ; Fascioliasis - veterinary ; fatty acid-binding proteins ; Fatty Acid-Binding Proteins - administration & dosage ; fecal egg count ; Female ; helminths ; immune response ; Immunoglobulin G - blood ; Immunologic Factors - administration & dosage ; Immunomodulator ; immunomodulators ; Lipidic aminoalcohol ; liver flukes ; Male ; Mice ; Mice, Inbred BALB C ; OA0012 ; Phlebodium ; Phlebodium pseudoaureum ; Sheep ; Sheep Diseases - immunology ; Sheep Diseases - parasitology ; Sheep Diseases - prevention & control ; Vaccine ; vaccine adjuvants ; vaccine development ; vaccines ; Vaccines - immunology</subject><ispartof>Veterinary parasitology, 2008-05, Vol.153 (1), p.176-181</ispartof><rights>2008 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-42ab246e9ad2dabe13aa33e169ec6af62b2257543a31a9f45814447906836e2c3</citedby><cites>FETCH-LOGICAL-c384t-42ab246e9ad2dabe13aa33e169ec6af62b2257543a31a9f45814447906836e2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304401708000472$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18308471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>López-Abán, J.</creatorcontrib><creatorcontrib>Nogal-Ruiz, J.J.</creatorcontrib><creatorcontrib>Vicente, B.</creatorcontrib><creatorcontrib>Morrondo, P.</creatorcontrib><creatorcontrib>Diez-Baños, P.</creatorcontrib><creatorcontrib>Hillyer, G.V.</creatorcontrib><creatorcontrib>Martínez-Fernández, A.R.</creatorcontrib><creatorcontrib>Feliciano, A. San</creatorcontrib><creatorcontrib>Muro, A.</creatorcontrib><title>The addition of a new immunomodulator with the adjuvant adaptation ADAD system using fatty acid binding proteins increases the protection against Fasciola hepatica</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>Fatty acid binding proteins (FABP) have shown protective immune response against
Fasciola hepatica infection. We evaluated the protection induced by the Fh12 FABP from
F. hepatica (Fh12) combined with the new immunomodulator the lipidic aminoalcohol OA0012 in the ADAD system in mice and sheep. In this work we introduced a lipidic aminoalcohol OA0012 as immunomodulator alone or in combination with the hydroalcoholic extract of
Phlebodium pseudoaureum; PAL. Mice vaccinated with ADAD containing OA0012
+
Fh12 or OA0012
+
Qs
+
Fh12 had survival rates of 40–50%. Sheep ADAD-vaccinated with OA0012
+
Qs
+
Fh12 showed lower fluke recovery, less hepatic lesions and higher post-infection daily weight gain than
F. hepatica infected control animals. Sheep ADAD-vaccinated with OA0012 combined PAL and Qs
+
Fh12 showed lower fluke recovery (42%), lower adult worms count (57%) lower faecal egg count (38%), less hepatic lesions and higher post-infection daily weight gain than
F. hepatica infected control animals. Thus, the addition of a new immunomodulator of synthesis to ADAD system with FABPs increased the protection against
F. hepatica.</description><subject>ADAD system</subject><subject>Adjuvants, Immunologic - administration & dosage</subject><subject>Animals</subject><subject>Antibodies, Helminth - blood</subject><subject>Antibodies, Helminth - immunology</subject><subject>disease control</subject><subject>FABP</subject><subject>Fasciola hepatica</subject><subject>Fasciola hepatica - immunology</subject><subject>Fascioliasis - prevention & control</subject><subject>Fascioliasis - veterinary</subject><subject>fatty acid-binding proteins</subject><subject>Fatty Acid-Binding Proteins - administration & dosage</subject><subject>fecal egg count</subject><subject>Female</subject><subject>helminths</subject><subject>immune response</subject><subject>Immunoglobulin G - blood</subject><subject>Immunologic Factors - administration & dosage</subject><subject>Immunomodulator</subject><subject>immunomodulators</subject><subject>Lipidic aminoalcohol</subject><subject>liver flukes</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>OA0012</subject><subject>Phlebodium</subject><subject>Phlebodium pseudoaureum</subject><subject>Sheep</subject><subject>Sheep Diseases - immunology</subject><subject>Sheep Diseases - parasitology</subject><subject>Sheep Diseases - prevention & control</subject><subject>Vaccine</subject><subject>vaccine adjuvants</subject><subject>vaccine development</subject><subject>vaccines</subject><subject>Vaccines - immunology</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAUhSMEokPhHyDwil3C9WPy2CCNWkqRKrGgXVt3nJsZj5I42M5U83v6R_E8JHasbF1_5_jqnCz7yKHgwMuvu2JPcUJfCIC6AF6AkK-yBa8rmYvlEl5nC5CgcgW8usrehbADAAVl9Ta74rWEWlV8kb08bolh29po3chcx5CN9MzsMMyjG1w79xidZ882blk8obt5j2NMF5winlSr29UtC4cQaWBzsOOGdRjjgaGxLVvbsT2OJu8i2TEwOxpPGCic_E5jc7LBDab3yO4wGOt6ZFua0gcG32dvOuwDfbic19nT3ffHm_v84dePnzerh9zIWsVcCVwLVVKDrWhxTVwiSkm8bMiU2JViLcSyWiqJkmPTqWXNlVJVA2UtSxJGXmdfzr5pqT8zhagHGwz1PY7k5qArUHXZQJNAdQaNdyF46vTk7YD-oDnoYzl6p8_l6GM5GrhO5STZp4v_vB6o_Se6tJGAz2egQ6dx423QT78FcJksK6FEmYhvZ4JSDntLXqesaDTUWp9i1K2z_9_hL57ZruQ</recordid><startdate>20080506</startdate><enddate>20080506</enddate><creator>López-Abán, J.</creator><creator>Nogal-Ruiz, J.J.</creator><creator>Vicente, B.</creator><creator>Morrondo, P.</creator><creator>Diez-Baños, P.</creator><creator>Hillyer, G.V.</creator><creator>Martínez-Fernández, A.R.</creator><creator>Feliciano, A. San</creator><creator>Muro, A.</creator><general>Elsevier B.V</general><general>Amsterdam; New York: Elsevier</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080506</creationdate><title>The addition of a new immunomodulator with the adjuvant adaptation ADAD system using fatty acid binding proteins increases the protection against Fasciola hepatica</title><author>López-Abán, J. ; Nogal-Ruiz, J.J. ; Vicente, B. ; Morrondo, P. ; Diez-Baños, P. ; Hillyer, G.V. ; Martínez-Fernández, A.R. ; Feliciano, A. San ; Muro, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-42ab246e9ad2dabe13aa33e169ec6af62b2257543a31a9f45814447906836e2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>ADAD system</topic><topic>Adjuvants, Immunologic - administration & dosage</topic><topic>Animals</topic><topic>Antibodies, Helminth - blood</topic><topic>Antibodies, Helminth - immunology</topic><topic>disease control</topic><topic>FABP</topic><topic>Fasciola hepatica</topic><topic>Fasciola hepatica - immunology</topic><topic>Fascioliasis - prevention & control</topic><topic>Fascioliasis - veterinary</topic><topic>fatty acid-binding proteins</topic><topic>Fatty Acid-Binding Proteins - administration & dosage</topic><topic>fecal egg count</topic><topic>Female</topic><topic>helminths</topic><topic>immune response</topic><topic>Immunoglobulin G - blood</topic><topic>Immunologic Factors - administration & dosage</topic><topic>Immunomodulator</topic><topic>immunomodulators</topic><topic>Lipidic aminoalcohol</topic><topic>liver flukes</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>OA0012</topic><topic>Phlebodium</topic><topic>Phlebodium pseudoaureum</topic><topic>Sheep</topic><topic>Sheep Diseases - immunology</topic><topic>Sheep Diseases - parasitology</topic><topic>Sheep Diseases - prevention & control</topic><topic>Vaccine</topic><topic>vaccine adjuvants</topic><topic>vaccine development</topic><topic>vaccines</topic><topic>Vaccines - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>López-Abán, J.</creatorcontrib><creatorcontrib>Nogal-Ruiz, J.J.</creatorcontrib><creatorcontrib>Vicente, B.</creatorcontrib><creatorcontrib>Morrondo, P.</creatorcontrib><creatorcontrib>Diez-Baños, P.</creatorcontrib><creatorcontrib>Hillyer, G.V.</creatorcontrib><creatorcontrib>Martínez-Fernández, A.R.</creatorcontrib><creatorcontrib>Feliciano, A. San</creatorcontrib><creatorcontrib>Muro, A.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>López-Abán, J.</au><au>Nogal-Ruiz, J.J.</au><au>Vicente, B.</au><au>Morrondo, P.</au><au>Diez-Baños, P.</au><au>Hillyer, G.V.</au><au>Martínez-Fernández, A.R.</au><au>Feliciano, A. San</au><au>Muro, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The addition of a new immunomodulator with the adjuvant adaptation ADAD system using fatty acid binding proteins increases the protection against Fasciola hepatica</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>2008-05-06</date><risdate>2008</risdate><volume>153</volume><issue>1</issue><spage>176</spage><epage>181</epage><pages>176-181</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>Fatty acid binding proteins (FABP) have shown protective immune response against
Fasciola hepatica infection. We evaluated the protection induced by the Fh12 FABP from
F. hepatica (Fh12) combined with the new immunomodulator the lipidic aminoalcohol OA0012 in the ADAD system in mice and sheep. In this work we introduced a lipidic aminoalcohol OA0012 as immunomodulator alone or in combination with the hydroalcoholic extract of
Phlebodium pseudoaureum; PAL. Mice vaccinated with ADAD containing OA0012
+
Fh12 or OA0012
+
Qs
+
Fh12 had survival rates of 40–50%. Sheep ADAD-vaccinated with OA0012
+
Qs
+
Fh12 showed lower fluke recovery, less hepatic lesions and higher post-infection daily weight gain than
F. hepatica infected control animals. Sheep ADAD-vaccinated with OA0012 combined PAL and Qs
+
Fh12 showed lower fluke recovery (42%), lower adult worms count (57%) lower faecal egg count (38%), less hepatic lesions and higher post-infection daily weight gain than
F. hepatica infected control animals. Thus, the addition of a new immunomodulator of synthesis to ADAD system with FABPs increased the protection against
F. hepatica.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>18308471</pmid><doi>10.1016/j.vetpar.2008.01.023</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-4017 |
| ispartof | Veterinary parasitology, 2008-05, Vol.153 (1), p.176-181 |
| issn | 0304-4017 1873-2550 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70486909 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ADAD system Adjuvants, Immunologic - administration & dosage Animals Antibodies, Helminth - blood Antibodies, Helminth - immunology disease control FABP Fasciola hepatica Fasciola hepatica - immunology Fascioliasis - prevention & control Fascioliasis - veterinary fatty acid-binding proteins Fatty Acid-Binding Proteins - administration & dosage fecal egg count Female helminths immune response Immunoglobulin G - blood Immunologic Factors - administration & dosage Immunomodulator immunomodulators Lipidic aminoalcohol liver flukes Male Mice Mice, Inbred BALB C OA0012 Phlebodium Phlebodium pseudoaureum Sheep Sheep Diseases - immunology Sheep Diseases - parasitology Sheep Diseases - prevention & control Vaccine vaccine adjuvants vaccine development vaccines Vaccines - immunology |
| title | The addition of a new immunomodulator with the adjuvant adaptation ADAD system using fatty acid binding proteins increases the protection against Fasciola hepatica |
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