Facilitated sprouting in a peripheral nerve injury

Abstract During regeneration of injured peripheral nerves, local conditions may influence how regenerative axon sprouts emerge from parent axons. More extensive lesions might be expected to disrupt such growth. In this work, we discovered instead that long segmental crush injuries facilitate the gro...

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Veröffentlicht in:	Neuroscience 2008-04, Vol.152 (4), p.877-887
Hauptverfasser:	Xu, Q.G, Midha, R, Martinez, J.A, Guo, G.F, Zochodne, D.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals axon regeneration Axons - metabolism Axons - physiology Biological and medical sciences Disease Models, Animal endoneurial microenvironment Fundamental and applied biological sciences. Psychology Gene Expression Regulation Glial Fibrillary Acidic Protein - metabolism Hedgehog Proteins - metabolism Laser-Doppler Flowmetry - methods Male Nerve Fibers, Myelinated - pathology Nerve Fibers, Myelinated - physiology Nerve Regeneration - physiology Neurofilament Proteins - metabolism Neurology Neurons - metabolism Neurons - pathology Nitric Oxide Synthase Type II - metabolism peripheral nerve peripheral nerve injury Rats Rats, Sprague-Dawley Receptor, Nerve Growth Factor - metabolism Regional Blood Flow - physiology Sciatic Neuropathy - metabolism Sciatic Neuropathy - pathology Sciatic Neuropathy - physiopathology sonic hedgehog protein Stilbamidines - metabolism Time Factors Vertebrates: nervous system and sense organs
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