Monitoring of chemotherapy successfulness of platina/taxol chemotherapy protocol by using determination of serum urokinase plasminogen activator (uPA) and soluble urokinase plasminogen activator receptor (suPAR) in patients with ovarian carcinoma FIGO II and III stage
In about 70% of cases, ovarian carcinoma has been diagnosed at an advanced stage. Invasion and metastasis of solid tumors request protease activity resulting in basal membrane destruction and surrounding matrix. In that process, urokinase plasminogen activator (uPA) and its receptor, urokinase plasm...
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| Veröffentlicht in: | Bosnian journal of basic medical sciences 2007-05, Vol.7 (2), p.111-116 |
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| description | In about 70% of cases, ovarian carcinoma has been diagnosed at an advanced stage. Invasion and metastasis of solid tumors request protease activity resulting in basal membrane destruction and surrounding matrix. In that process, urokinase plasminogen activator (uPA) and its receptor, urokinase plasminogen activator receptor (suPAR) play a key role, that via plasmin activation lead to basal membrane and matrix degradation in surrounding of the tumor, enable to its invasion and metastasis. Determination of serum concentration of those tumor markers can be useful in preoperative as well as in postoperative period. Their serum concentrations in ovarian cancer patients may help in good monitoring of remission or progression during chemotherapy treatment. In late 1950s and ear1y 1960s, when it was found out that malignant ovarian tumors were chemosensitive, their chemotherapy treatment has begun. In the beginning it was used only mono-therapy, and by discovering new cytostatics it was replaced by poly-chemotherapy. Now days, in the therapy of advanced stages of ovarian carcinoma combination of cisplatine or carboplatine with paclitaxel is considering as standard treatment. Aim of this study was to determine serum uPA, suPAR and CEA in FIGO II and III patients with different histological type (serous, mucinous, clear cell tumor) before and after PT chemotherapy protocol during following three cycles. In this prospective study we have analyzed 17 patients with ovarian carcinoma, those have been after surgery treated by chemotherapy. Serum levels of uPA and suPAR have been determined by ELISA-test (Imubind uPA, Imubind uPAR, American Diagnostica), and CEA by OPUS Imunoassay method. Results of this study have shown that uPA, suPAR and CEA met criteria for prognostic markers for monitoring of successfulness of platina/taxol chemotherapy protocol for serous, mucinous and clear cell tumor FIGO II and III stage of ovarian carcinoma. In case of PT chemotherapy protocol suPAR was better prognostic marker for monitoring of chemotherapy successfulness (Pearson coefficient 0,9 do 1,0; p |
| doi_str_mv | 10.17305/bjbms.2007.3063 |
| format | Article |
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Invasion and metastasis of solid tumors request protease activity resulting in basal membrane destruction and surrounding matrix. In that process, urokinase plasminogen activator (uPA) and its receptor, urokinase plasminogen activator receptor (suPAR) play a key role, that via plasmin activation lead to basal membrane and matrix degradation in surrounding of the tumor, enable to its invasion and metastasis. Determination of serum concentration of those tumor markers can be useful in preoperative as well as in postoperative period. Their serum concentrations in ovarian cancer patients may help in good monitoring of remission or progression during chemotherapy treatment. In late 1950s and ear1y 1960s, when it was found out that malignant ovarian tumors were chemosensitive, their chemotherapy treatment has begun. In the beginning it was used only mono-therapy, and by discovering new cytostatics it was replaced by poly-chemotherapy. Now days, in the therapy of advanced stages of ovarian carcinoma combination of cisplatine or carboplatine with paclitaxel is considering as standard treatment. Aim of this study was to determine serum uPA, suPAR and CEA in FIGO II and III patients with different histological type (serous, mucinous, clear cell tumor) before and after PT chemotherapy protocol during following three cycles. In this prospective study we have analyzed 17 patients with ovarian carcinoma, those have been after surgery treated by chemotherapy. Serum levels of uPA and suPAR have been determined by ELISA-test (Imubind uPA, Imubind uPAR, American Diagnostica), and CEA by OPUS Imunoassay method. Results of this study have shown that uPA, suPAR and CEA met criteria for prognostic markers for monitoring of successfulness of platina/taxol chemotherapy protocol for serous, mucinous and clear cell tumor FIGO II and III stage of ovarian carcinoma. In case of PT chemotherapy protocol suPAR was better prognostic marker for monitoring of chemotherapy successfulness (Pearson coefficient 0,9 do 1,0; p<0,00l) than uPA (Pearson coefficient between 0,86 and 0,92; p<0,02) and CEA (Pearson coefficient 0,5 do 0,89; p<0,04).</description><identifier>ISSN: 1512-8601</identifier><identifier>DOI: 10.17305/bjbms.2007.3063</identifier><identifier>PMID: 17489744</identifier><language>eng</language><publisher>Bosnia and Herzegovina</publisher><subject>Adenocarcinoma, Clear Cell - blood ; Adenocarcinoma, Clear Cell - drug therapy ; Adenocarcinoma, Clear Cell - pathology ; Adenocarcinoma, Mucinous - blood ; Adenocarcinoma, Mucinous - drug therapy ; Adenocarcinoma, Mucinous - pathology ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Carboplatin - administration & dosage ; Cisplatin - administration & dosage ; Dose-Response Relationship, Drug ; Female ; Humans ; Middle Aged ; Neoplasm Staging ; Ovarian Neoplasms - blood ; Ovarian Neoplasms - drug therapy ; Ovarian Neoplasms - pathology ; Paclitaxel - administration & dosage ; Prognosis ; Prospective Studies ; Receptors, Cell Surface - blood ; Receptors, Urokinase Plasminogen Activator ; Treatment Outcome ; Urokinase-Type Plasminogen Activator - blood</subject><ispartof>Bosnian journal of basic medical sciences, 2007-05, Vol.7 (2), p.111-116</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17489744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ljuca, Dzenita</creatorcontrib><creatorcontrib>Fatusić, Zlatan</creatorcontrib><creatorcontrib>Iljazović, Ermina</creatorcontrib><creatorcontrib>Ahmetović, Begzudin</creatorcontrib><title>Monitoring of chemotherapy successfulness of platina/taxol chemotherapy protocol by using determination of serum urokinase plasminogen activator (uPA) and soluble urokinase plasminogen activator receptor (suPAR) in patients with ovarian carcinoma FIGO II and III stage</title><title>Bosnian journal of basic medical sciences</title><addtitle>Bosn J Basic Med Sci</addtitle><description>In about 70% of cases, ovarian carcinoma has been diagnosed at an advanced stage. Invasion and metastasis of solid tumors request protease activity resulting in basal membrane destruction and surrounding matrix. In that process, urokinase plasminogen activator (uPA) and its receptor, urokinase plasminogen activator receptor (suPAR) play a key role, that via plasmin activation lead to basal membrane and matrix degradation in surrounding of the tumor, enable to its invasion and metastasis. Determination of serum concentration of those tumor markers can be useful in preoperative as well as in postoperative period. Their serum concentrations in ovarian cancer patients may help in good monitoring of remission or progression during chemotherapy treatment. In late 1950s and ear1y 1960s, when it was found out that malignant ovarian tumors were chemosensitive, their chemotherapy treatment has begun. In the beginning it was used only mono-therapy, and by discovering new cytostatics it was replaced by poly-chemotherapy. Now days, in the therapy of advanced stages of ovarian carcinoma combination of cisplatine or carboplatine with paclitaxel is considering as standard treatment. Aim of this study was to determine serum uPA, suPAR and CEA in FIGO II and III patients with different histological type (serous, mucinous, clear cell tumor) before and after PT chemotherapy protocol during following three cycles. In this prospective study we have analyzed 17 patients with ovarian carcinoma, those have been after surgery treated by chemotherapy. Serum levels of uPA and suPAR have been determined by ELISA-test (Imubind uPA, Imubind uPAR, American Diagnostica), and CEA by OPUS Imunoassay method. Results of this study have shown that uPA, suPAR and CEA met criteria for prognostic markers for monitoring of successfulness of platina/taxol chemotherapy protocol for serous, mucinous and clear cell tumor FIGO II and III stage of ovarian carcinoma. In case of PT chemotherapy protocol suPAR was better prognostic marker for monitoring of chemotherapy successfulness (Pearson coefficient 0,9 do 1,0; p<0,00l) than uPA (Pearson coefficient between 0,86 and 0,92; p<0,02) and CEA (Pearson coefficient 0,5 do 0,89; p<0,04).</description><subject>Adenocarcinoma, Clear Cell - blood</subject><subject>Adenocarcinoma, Clear Cell - drug therapy</subject><subject>Adenocarcinoma, Clear Cell - pathology</subject><subject>Adenocarcinoma, Mucinous - blood</subject><subject>Adenocarcinoma, Mucinous - drug therapy</subject><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Carboplatin - administration & dosage</subject><subject>Cisplatin - administration & dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Ovarian Neoplasms - blood</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Paclitaxel - administration & dosage</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Receptors, Cell Surface - blood</subject><subject>Receptors, Urokinase Plasminogen Activator</subject><subject>Treatment Outcome</subject><subject>Urokinase-Type Plasminogen Activator - blood</subject><issn>1512-8601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxYMEol_cOSGfED3s1rETOzlWFS2RiooQnFe2M951SezgsQv739dbyoETpyfNvN-b0UxVva3pupacthf6Xs-4ZpTKNaeCv6yO67Zmq07Q-qg6QbynVPS8a15XR7Vsul42zfGLs8_BuxSi81sSLDE7mEPaQVTLnmA2BhBtnnyRQ3uZVHJeXST1O0z_mpcYUjClqvck4yFuhARxLvbkgj_QCDHPJMfwoxQRDmlY-mELniiT3IMqi5AP-cvlOVF-JBimrCf4LxHBwPKEYmG_nhPnyVKmgk9Ifrm0I-FBRac8MSqags-KXA83d2QYnuYMRTGpLZxVr6yaEN4862n1_frjt6tPq9u7m-Hq8na1MNqnFR_BMqtl10mptNCstorpfuxt17a0ZZ1tqeh6RlkvmZIW7NgKrkchKBNMc35avf-TW472MwOmzezQwDQpDyHjRtKmE6xvivHdszHrGcbNEt2s4n7z93_8EZa8ovo</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Ljuca, Dzenita</creator><creator>Fatusić, Zlatan</creator><creator>Iljazović, Ermina</creator><creator>Ahmetović, Begzudin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Monitoring of chemotherapy successfulness of platina/taxol chemotherapy protocol by using determination of serum urokinase plasminogen activator (uPA) and soluble urokinase plasminogen activator receptor (suPAR) in patients with ovarian carcinoma FIGO II and III stage</title><author>Ljuca, Dzenita ; Fatusić, Zlatan ; Iljazović, Ermina ; Ahmetović, Begzudin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-3def2fb78877ab6b21fa2b9d9f8550528f50689202972a7fefd563bd660262b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenocarcinoma, Clear Cell - blood</topic><topic>Adenocarcinoma, Clear Cell - drug therapy</topic><topic>Adenocarcinoma, Clear Cell - pathology</topic><topic>Adenocarcinoma, Mucinous - blood</topic><topic>Adenocarcinoma, Mucinous - drug therapy</topic><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Carboplatin - administration & dosage</topic><topic>Cisplatin - administration & dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Ovarian Neoplasms - blood</topic><topic>Ovarian Neoplasms - drug therapy</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Paclitaxel - administration & dosage</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Receptors, Cell Surface - blood</topic><topic>Receptors, Urokinase Plasminogen Activator</topic><topic>Treatment Outcome</topic><topic>Urokinase-Type Plasminogen Activator - blood</topic><toplevel>online_resources</toplevel><creatorcontrib>Ljuca, Dzenita</creatorcontrib><creatorcontrib>Fatusić, Zlatan</creatorcontrib><creatorcontrib>Iljazović, Ermina</creatorcontrib><creatorcontrib>Ahmetović, Begzudin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Bosnian journal of basic medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ljuca, Dzenita</au><au>Fatusić, Zlatan</au><au>Iljazović, Ermina</au><au>Ahmetović, Begzudin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monitoring of chemotherapy successfulness of platina/taxol chemotherapy protocol by using determination of serum urokinase plasminogen activator (uPA) and soluble urokinase plasminogen activator receptor (suPAR) in patients with ovarian carcinoma FIGO II and III stage</atitle><jtitle>Bosnian journal of basic medical sciences</jtitle><addtitle>Bosn J Basic Med Sci</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>7</volume><issue>2</issue><spage>111</spage><epage>116</epage><pages>111-116</pages><issn>1512-8601</issn><abstract>In about 70% of cases, ovarian carcinoma has been diagnosed at an advanced stage. Invasion and metastasis of solid tumors request protease activity resulting in basal membrane destruction and surrounding matrix. In that process, urokinase plasminogen activator (uPA) and its receptor, urokinase plasminogen activator receptor (suPAR) play a key role, that via plasmin activation lead to basal membrane and matrix degradation in surrounding of the tumor, enable to its invasion and metastasis. Determination of serum concentration of those tumor markers can be useful in preoperative as well as in postoperative period. Their serum concentrations in ovarian cancer patients may help in good monitoring of remission or progression during chemotherapy treatment. In late 1950s and ear1y 1960s, when it was found out that malignant ovarian tumors were chemosensitive, their chemotherapy treatment has begun. In the beginning it was used only mono-therapy, and by discovering new cytostatics it was replaced by poly-chemotherapy. Now days, in the therapy of advanced stages of ovarian carcinoma combination of cisplatine or carboplatine with paclitaxel is considering as standard treatment. Aim of this study was to determine serum uPA, suPAR and CEA in FIGO II and III patients with different histological type (serous, mucinous, clear cell tumor) before and after PT chemotherapy protocol during following three cycles. In this prospective study we have analyzed 17 patients with ovarian carcinoma, those have been after surgery treated by chemotherapy. Serum levels of uPA and suPAR have been determined by ELISA-test (Imubind uPA, Imubind uPAR, American Diagnostica), and CEA by OPUS Imunoassay method. Results of this study have shown that uPA, suPAR and CEA met criteria for prognostic markers for monitoring of successfulness of platina/taxol chemotherapy protocol for serous, mucinous and clear cell tumor FIGO II and III stage of ovarian carcinoma. In case of PT chemotherapy protocol suPAR was better prognostic marker for monitoring of chemotherapy successfulness (Pearson coefficient 0,9 do 1,0; p<0,00l) than uPA (Pearson coefficient between 0,86 and 0,92; p<0,02) and CEA (Pearson coefficient 0,5 do 0,89; p<0,04).</abstract><cop>Bosnia and Herzegovina</cop><pmid>17489744</pmid><doi>10.17305/bjbms.2007.3063</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Bosnian journal of basic medical sciences, 2007-05, Vol.7 (2), p.111-116 |
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| subjects | Adenocarcinoma, Clear Cell - blood Adenocarcinoma, Clear Cell - drug therapy Adenocarcinoma, Clear Cell - pathology Adenocarcinoma, Mucinous - blood Adenocarcinoma, Mucinous - drug therapy Adenocarcinoma, Mucinous - pathology Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carboplatin - administration & dosage Cisplatin - administration & dosage Dose-Response Relationship, Drug Female Humans Middle Aged Neoplasm Staging Ovarian Neoplasms - blood Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Paclitaxel - administration & dosage Prognosis Prospective Studies Receptors, Cell Surface - blood Receptors, Urokinase Plasminogen Activator Treatment Outcome Urokinase-Type Plasminogen Activator - blood |
| title | Monitoring of chemotherapy successfulness of platina/taxol chemotherapy protocol by using determination of serum urokinase plasminogen activator (uPA) and soluble urokinase plasminogen activator receptor (suPAR) in patients with ovarian carcinoma FIGO II and III stage |
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