Altered Ca(2+) handling by ryanodine receptor and Na(+)-Ca(2+) exchange in the heart from ovariectomized rats: role of protein kinase A

Our previous study has demonstrated that ovariectomy (Ovx) significantly increased the left ventricular developed pressure (LVDP) and the maximal rate of developed pressure over time (+/-dP/dt(max)) in the isolated perfused rat heart and the effects were reversed by female sex hormone replacement. I...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2007-05, Vol.292 (5), p.C1625-C1635
Hauptverfasser:	Kravtsov, Gennadi M, Kam, Kenneth W L, Liu, Jing, Wu, Song, Wong, Tak Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caffeine - pharmacology Calcium Signaling - drug effects Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Electric Stimulation Estrogens - metabolism Estrogens - pharmacology Female Heart Ventricles - cytology Heart Ventricles - metabolism Homeostasis Myocardial Contraction Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Ovariectomy Protein Kinase Inhibitors - pharmacology Rats Rats, Sprague-Dawley Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Sodium-Calcium Exchanger - metabolism Time Factors Up-Regulation Ventricular Function, Left
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