P-glycoprotein function and expression during obstructive cholestasis in rats

OBJECTIVESThe present study was aimed at evaluation of in vivo biliary and renal excretion of rhodamine 123 (Rho123), a P-glycoprotein (P-gp) substrate, in rats during either acute or chronic cholestasis induced by bile duct obstruction (BDO). METHODSThe Rho123 clearance study was performed either o...

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Veröffentlicht in:	European journal of gastroenterology & hepatology 2008-05, Vol.20 (5), p.404-412
Hauptverfasser:	Micuda, Stanislav, Brcakova, Eva, Fuksa, Leos, Cermanova, Jolana, Osterreicher, Jan, Hroch, Milos, Mokry, Jaroslav, Pejchal, Jaroslav, Martinkova, Jirina, Staud, Frantisek
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism ATP-Binding Cassette, Sub-Family B, Member 1 - physiology Bile - metabolism Bilirubin - metabolism Biological and medical sciences Blotting, Western Cholestasis, Extrahepatic - etiology Cholestasis, Extrahepatic - metabolism Chronic Disease Disease Models, Animal Fluorescent Dyes Gastroenterology. Liver. Pancreas. Abdomen Kidney - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Other diseases. Semiology Rats Rats, Wistar Rhodamine 123
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