Association of interindividual differences in p14ARF promoter methylation with single nucleotide polymorphism in primary colorectal cancer

BACKGROUND CpG island hypermethylation has been reported at the promoter region of many tumor suppressor genes in colorectal cancers. However, there are significant interindividual differences in the degree of DNA methylation in colorectal cancers. The objective of the current study was to understan...

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Veröffentlicht in:	Cancer 2008-04, Vol.112 (8), p.1699-1707
Hauptverfasser:	Kang, Mi Yeon, Lee, Bo Bin, Ji, Yong Ick, Jung, Eun Hyun, Chun, Ho‐Kyung, Song, Sang Yong, Park, Seong‐Eun, Park, Joobae, Kim, Duk‐Hwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Biological and medical sciences Colonic Neoplasms - genetics colorectal cancer CpG Islands - genetics Cytosine DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases DNA Methylation DNA Methyltransferase 3B Female Gastroenterology. Liver. Pancreas. Abdomen Genetic Variation - genetics Genotype Guanine Haplotypes Homozygote Humans hypermethylation Linkage Disequilibrium - genetics Male Medical sciences Middle Aged p14ARF Polymerase Chain Reaction polymorphism Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic - genetics Rectal Neoplasms - genetics RNA, Messenger - genetics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Stomach. Duodenum. Small intestine. Colon. Rectum. Anus susceptibility Thymine Tumor Suppressor Protein p14ARF - genetics Tumors
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