Association between activation of phase 2 enzymes and down-regulation of dendritic cell maturation by c9,t11-conjugated linoleic acid

Abstract Antioxidant and cytoprotective enzymes (phase 2) exert protective activity against reactive oxygen species (ROS)-induced injury. We have recently shown how the beneficial effects of conjugated linoleic acid (CLA) in a mouse model of an autoimmune disease are parallel with the activation of...

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Veröffentlicht in:	Immunology letters 2008-05, Vol.117 (2), p.181-190
Hauptverfasser:	Bergamo, Paolo, Maurano, Francesco, D’Arienzo, Rossana, David, Chella, Rossi, Mauro
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antioxidants - metabolism Antioxidants - pharmacology Celiac Disease - drug therapy Celiac Disease - enzymology Celiac Disease - immunology Cell Differentiation - drug effects Conjugated linoleic acid Cytoprotection - drug effects Cytoprotection - immunology Dendritic cells Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - enzymology Disease Models, Animal Down-Regulation - drug effects Enzyme Activation - drug effects Glutamate-Cysteine Ligase - metabolism Heme Oxygenase-1 - metabolism Linoleic Acids, Conjugated - metabolism Linoleic Acids, Conjugated - pharmacology Lymphocyte Activation - drug effects Mice NADPH Dehydrogenase - metabolism Oxidation-Reduction - drug effects Phase 2 enzymes Reactive Oxygen Species - antagonists & inhibitors Subcellular Fractions - chemistry Subcellular Fractions - drug effects Subcellular Fractions - enzymology
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