AcrySof Natural filter decreases blue light-induced apoptosis in human retinal pigment epithelium
Purpose The effect of AcrySof filter (UV light-filtering chromophore; Alcon) and AcrySof Natural filter (UV- and blue light-filtering chromophores) on blue light-induced apoptosis in human retinal pigment epithelial (RPE) cells was evaluated. Design Laboratory investigation Clinical relevance Acryso...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2008-05, Vol.246 (5), p.671-676 |
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| creator | Rezai, Kourous A. Gasyna, Elzbieta Seagle, Brandon-Luke L. Norris, James R. Rezaei, Kasra A. |
| description | Purpose
The effect of AcrySof filter (UV light-filtering chromophore; Alcon) and AcrySof Natural filter (UV- and blue light-filtering chromophores) on blue light-induced apoptosis in human retinal pigment epithelial (RPE) cells was evaluated.
Design
Laboratory investigation
Clinical relevance
Acrysof Natural filter reduces the blue-light toxicity in RPE cells and may have a positive impact on age-related macular degeneration (AMD).
Methods
RPE cells were exposed to blue light (430–450 nm) in the presence of either the AcrySof (UV only) filter or Acrysof Natural (UV and blue light) filter for 10 days. The rate of apoptosis was analyzed.
Results
Blue light induced significant apoptosis in RPE cells. AcrySof Natural filter significantly reduced the blue light-induced apoptosis when compared to AcrySof filter. The amount of blue-light energy reaching the cells with the AcrySof filter was 4.25 mW/cm
2
and with the AcrySof Natural filter was 2.5 mW/cm
2
.
Conclusions
AcrySof Natural filter significantly reduced blue light-induced apoptosis. This was most likely due to its filtering effect on blue wavelength light, which reduces the energy that reaches the cells. In patients with cataract who are at a high risk for AMD, the implantation of a blue light-filtering intraocular lens may be considered. |
| doi_str_mv | 10.1007/s00417-006-0484-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70481303</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70481303</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-2296274f7c2d5656d433357e91d95736ff3daed3cb2dc4b0336239181c5dc3103</originalsourceid><addsrcrecordid>eNp1kD1rHDEQhkVwiC_n_IA0Qbhwp1jS7K52S2PsJGDiwja4Ezpp9k5mv6KPwv8-Ou7AYHA1xTzvO8NDyHfBfwrO1WXkvBKKcd4wXrUVk5_ISlRQM8Xl8wlZcSUFa0E-n5KvMb7wgkMtvpBT0cqua1W7IubKhteHuad_TcrBDLT3Q8JAHdqAJmKkmyEjHfx2l5ifXLboqFnmJc3RR-onusujmWjA5KcSX_x2xClRXHza4eDzeEY-92aI-O041-Tp9ubx-je7u__15_rqjllousSk7Bqpql5Z6eqmblwFALXCTriuVtD0PTiDDuxGOlttOEAjoROtsLWzIDisycWhdwnzv4wx6dFHi8NgJpxz1KooElBya3L-DnyZcyjPRy2Bt6IFtW8TB8iGOcaAvV6CH0141YLrvXx9kK-LfL2XX7Jr8uNYnDcjurfE0XYB5AGIZTVtMbxd_rj1P6Y6j14</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>230818370</pqid></control><display><type>article</type><title>AcrySof Natural filter decreases blue light-induced apoptosis in human retinal pigment epithelium</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Rezai, Kourous A. ; Gasyna, Elzbieta ; Seagle, Brandon-Luke L. ; Norris, James R. ; Rezaei, Kasra A.</creator><creatorcontrib>Rezai, Kourous A. ; Gasyna, Elzbieta ; Seagle, Brandon-Luke L. ; Norris, James R. ; Rezaei, Kasra A.</creatorcontrib><description>Purpose
The effect of AcrySof filter (UV light-filtering chromophore; Alcon) and AcrySof Natural filter (UV- and blue light-filtering chromophores) on blue light-induced apoptosis in human retinal pigment epithelial (RPE) cells was evaluated.
Design
Laboratory investigation
Clinical relevance
Acrysof Natural filter reduces the blue-light toxicity in RPE cells and may have a positive impact on age-related macular degeneration (AMD).
Methods
RPE cells were exposed to blue light (430–450 nm) in the presence of either the AcrySof (UV only) filter or Acrysof Natural (UV and blue light) filter for 10 days. The rate of apoptosis was analyzed.
Results
Blue light induced significant apoptosis in RPE cells. AcrySof Natural filter significantly reduced the blue light-induced apoptosis when compared to AcrySof filter. The amount of blue-light energy reaching the cells with the AcrySof filter was 4.25 mW/cm
2
and with the AcrySof Natural filter was 2.5 mW/cm
2
.
Conclusions
AcrySof Natural filter significantly reduced blue light-induced apoptosis. This was most likely due to its filtering effect on blue wavelength light, which reduces the energy that reaches the cells. In patients with cataract who are at a high risk for AMD, the implantation of a blue light-filtering intraocular lens may be considered.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-006-0484-2</identifier><identifier>PMID: 18299878</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Acrylic Resins ; Annexin A5 - metabolism ; Apoptosis - radiation effects ; Cell Count ; Cell Line ; Cell Survival - physiology ; Cytoprotection ; Filtration - instrumentation ; Flow Cytometry ; Humans ; Laboratory Investigation ; Lenses, Intraocular ; Light ; Lipofuscin - metabolism ; Medicine ; Medicine & Public Health ; Ophthalmology ; Oxidative Stress ; Pigment Epithelium of Eye - cytology ; Pigment Epithelium of Eye - metabolism ; Pigment Epithelium of Eye - radiation effects ; Pyridinium Compounds - metabolism ; Radiation Protection - instrumentation ; Retinoids - metabolism</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2008-05, Vol.246 (5), p.671-676</ispartof><rights>Springer-Verlag 2007</rights><rights>Springer-Verlag 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-2296274f7c2d5656d433357e91d95736ff3daed3cb2dc4b0336239181c5dc3103</citedby><cites>FETCH-LOGICAL-c369t-2296274f7c2d5656d433357e91d95736ff3daed3cb2dc4b0336239181c5dc3103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-006-0484-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-006-0484-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18299878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rezai, Kourous A.</creatorcontrib><creatorcontrib>Gasyna, Elzbieta</creatorcontrib><creatorcontrib>Seagle, Brandon-Luke L.</creatorcontrib><creatorcontrib>Norris, James R.</creatorcontrib><creatorcontrib>Rezaei, Kasra A.</creatorcontrib><title>AcrySof Natural filter decreases blue light-induced apoptosis in human retinal pigment epithelium</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
The effect of AcrySof filter (UV light-filtering chromophore; Alcon) and AcrySof Natural filter (UV- and blue light-filtering chromophores) on blue light-induced apoptosis in human retinal pigment epithelial (RPE) cells was evaluated.
Design
Laboratory investigation
Clinical relevance
Acrysof Natural filter reduces the blue-light toxicity in RPE cells and may have a positive impact on age-related macular degeneration (AMD).
Methods
RPE cells were exposed to blue light (430–450 nm) in the presence of either the AcrySof (UV only) filter or Acrysof Natural (UV and blue light) filter for 10 days. The rate of apoptosis was analyzed.
Results
Blue light induced significant apoptosis in RPE cells. AcrySof Natural filter significantly reduced the blue light-induced apoptosis when compared to AcrySof filter. The amount of blue-light energy reaching the cells with the AcrySof filter was 4.25 mW/cm
2
and with the AcrySof Natural filter was 2.5 mW/cm
2
.
Conclusions
AcrySof Natural filter significantly reduced blue light-induced apoptosis. This was most likely due to its filtering effect on blue wavelength light, which reduces the energy that reaches the cells. In patients with cataract who are at a high risk for AMD, the implantation of a blue light-filtering intraocular lens may be considered.</description><subject>Acrylic Resins</subject><subject>Annexin A5 - metabolism</subject><subject>Apoptosis - radiation effects</subject><subject>Cell Count</subject><subject>Cell Line</subject><subject>Cell Survival - physiology</subject><subject>Cytoprotection</subject><subject>Filtration - instrumentation</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Laboratory Investigation</subject><subject>Lenses, Intraocular</subject><subject>Light</subject><subject>Lipofuscin - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Oxidative Stress</subject><subject>Pigment Epithelium of Eye - cytology</subject><subject>Pigment Epithelium of Eye - metabolism</subject><subject>Pigment Epithelium of Eye - radiation effects</subject><subject>Pyridinium Compounds - metabolism</subject><subject>Radiation Protection - instrumentation</subject><subject>Retinoids - metabolism</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kD1rHDEQhkVwiC_n_IA0Qbhwp1jS7K52S2PsJGDiwja4Ezpp9k5mv6KPwv8-Ou7AYHA1xTzvO8NDyHfBfwrO1WXkvBKKcd4wXrUVk5_ISlRQM8Xl8wlZcSUFa0E-n5KvMb7wgkMtvpBT0cqua1W7IubKhteHuad_TcrBDLT3Q8JAHdqAJmKkmyEjHfx2l5ifXLboqFnmJc3RR-onusujmWjA5KcSX_x2xClRXHza4eDzeEY-92aI-O041-Tp9ubx-je7u__15_rqjllousSk7Bqpql5Z6eqmblwFALXCTriuVtD0PTiDDuxGOlttOEAjoROtsLWzIDisycWhdwnzv4wx6dFHi8NgJpxz1KooElBya3L-DnyZcyjPRy2Bt6IFtW8TB8iGOcaAvV6CH0141YLrvXx9kK-LfL2XX7Jr8uNYnDcjurfE0XYB5AGIZTVtMbxd_rj1P6Y6j14</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Rezai, Kourous A.</creator><creator>Gasyna, Elzbieta</creator><creator>Seagle, Brandon-Luke L.</creator><creator>Norris, James R.</creator><creator>Rezaei, Kasra A.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080501</creationdate><title>AcrySof Natural filter decreases blue light-induced apoptosis in human retinal pigment epithelium</title><author>Rezai, Kourous A. ; Gasyna, Elzbieta ; Seagle, Brandon-Luke L. ; Norris, James R. ; Rezaei, Kasra A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-2296274f7c2d5656d433357e91d95736ff3daed3cb2dc4b0336239181c5dc3103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acrylic Resins</topic><topic>Annexin A5 - metabolism</topic><topic>Apoptosis - radiation effects</topic><topic>Cell Count</topic><topic>Cell Line</topic><topic>Cell Survival - physiology</topic><topic>Cytoprotection</topic><topic>Filtration - instrumentation</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Laboratory Investigation</topic><topic>Lenses, Intraocular</topic><topic>Light</topic><topic>Lipofuscin - metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Oxidative Stress</topic><topic>Pigment Epithelium of Eye - cytology</topic><topic>Pigment Epithelium of Eye - metabolism</topic><topic>Pigment Epithelium of Eye - radiation effects</topic><topic>Pyridinium Compounds - metabolism</topic><topic>Radiation Protection - instrumentation</topic><topic>Retinoids - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rezai, Kourous A.</creatorcontrib><creatorcontrib>Gasyna, Elzbieta</creatorcontrib><creatorcontrib>Seagle, Brandon-Luke L.</creatorcontrib><creatorcontrib>Norris, James R.</creatorcontrib><creatorcontrib>Rezaei, Kasra A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rezai, Kourous A.</au><au>Gasyna, Elzbieta</au><au>Seagle, Brandon-Luke L.</au><au>Norris, James R.</au><au>Rezaei, Kasra A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AcrySof Natural filter decreases blue light-induced apoptosis in human retinal pigment epithelium</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>246</volume><issue>5</issue><spage>671</spage><epage>676</epage><pages>671-676</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
The effect of AcrySof filter (UV light-filtering chromophore; Alcon) and AcrySof Natural filter (UV- and blue light-filtering chromophores) on blue light-induced apoptosis in human retinal pigment epithelial (RPE) cells was evaluated.
Design
Laboratory investigation
Clinical relevance
Acrysof Natural filter reduces the blue-light toxicity in RPE cells and may have a positive impact on age-related macular degeneration (AMD).
Methods
RPE cells were exposed to blue light (430–450 nm) in the presence of either the AcrySof (UV only) filter or Acrysof Natural (UV and blue light) filter for 10 days. The rate of apoptosis was analyzed.
Results
Blue light induced significant apoptosis in RPE cells. AcrySof Natural filter significantly reduced the blue light-induced apoptosis when compared to AcrySof filter. The amount of blue-light energy reaching the cells with the AcrySof filter was 4.25 mW/cm
2
and with the AcrySof Natural filter was 2.5 mW/cm
2
.
Conclusions
AcrySof Natural filter significantly reduced blue light-induced apoptosis. This was most likely due to its filtering effect on blue wavelength light, which reduces the energy that reaches the cells. In patients with cataract who are at a high risk for AMD, the implantation of a blue light-filtering intraocular lens may be considered.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18299878</pmid><doi>10.1007/s00417-006-0484-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2008-05, Vol.246 (5), p.671-676 |
| issn | 0721-832X 1435-702X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70481303 |
| source | MEDLINE; Springer Online Journals Complete |
| subjects | Acrylic Resins Annexin A5 - metabolism Apoptosis - radiation effects Cell Count Cell Line Cell Survival - physiology Cytoprotection Filtration - instrumentation Flow Cytometry Humans Laboratory Investigation Lenses, Intraocular Light Lipofuscin - metabolism Medicine Medicine & Public Health Ophthalmology Oxidative Stress Pigment Epithelium of Eye - cytology Pigment Epithelium of Eye - metabolism Pigment Epithelium of Eye - radiation effects Pyridinium Compounds - metabolism Radiation Protection - instrumentation Retinoids - metabolism |
| title | AcrySof Natural filter decreases blue light-induced apoptosis in human retinal pigment epithelium |
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