Ghrelin selectively reduces mechanosensitivity of upper gastrointestinal vagal afferents

Ghrelin is a peptide released from gastric endocrine cells that has an orexigenic effect via a vagal pathway. Here we determine the effect of ghrelin on mechanosensitivity of upper-intestinal vagal afferent fibers in ferret and mouse. The responses of gastroesophageal vagal afferents to graded mecha...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2007-05, Vol.292 (5), p.G1376-G1384
Hauptverfasser:	Page, Amanda J, Slattery, James A, Milte, Catherine, Laker, Rhianna, O'Donnell, Tracey, Dorian, Camilla, Brierley, Stuart M, Blackshaw, L Ashley
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent Pathways - drug effects Afferent Pathways - physiology Animals Cells Digestive system Esophagus - innervation Female Ferrets Gastroenterology Ghrelin Mechanoreceptors - drug effects Mechanoreceptors - physiology Mice Nodose Ganglion - physiology Oligopeptides - pharmacology Peptide Hormones - pharmacology Peptides Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, Ghrelin Stomach - innervation Vagus Nerve - physiology
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