Proof of an Association between Helicobacter pylori and Idiopathic Thrombocytopenic Purpura in Latin America
Background: Association between Helicobacter pylori and idiopathic thrombocytopenic purpura (ITP) has been found in Japan and in some European countries. It has also been shown that eradication of H. pylori can increase platelet counts in patients with ITP. The aims of this study were to determine...
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| Veröffentlicht in: | Helicobacter (Cambridge, Mass.) Mass.), 2007-06, Vol.12 (3), p.265-273 |
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| description | Background: Association between Helicobacter pylori and idiopathic thrombocytopenic purpura (ITP) has been found in Japan and in some European countries. It has also been shown that eradication of H. pylori can increase platelet counts in patients with ITP. The aims of this study were to determine the prevalence of H. pylori infection in patients with ITP in Colombia, and the effect of bacterial eradication on their platelet counts.
Materials and methods: Between December 1998 and April 2006, a total of 32 patients diagnosed with ITP were included in the study. Controls were age and sex matched.
Results: H. pylori infection in patients with ITP was significantly higher (p = .00006) than in control individuals (90.6% and 43.8%, respectively), as determined by 13C‐urea breath test. A significant association between H. pylori infection and ITP was found (p |
| doi_str_mv | 10.1111/j.1523-5378.2007.00502.x |
| format | Article |
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Materials and methods: Between December 1998 and April 2006, a total of 32 patients diagnosed with ITP were included in the study. Controls were age and sex matched.
Results: H. pylori infection in patients with ITP was significantly higher (p = .00006) than in control individuals (90.6% and 43.8%, respectively), as determined by 13C‐urea breath test. A significant association between H. pylori infection and ITP was found (p < .0003), with an odds ratio (OR) of 13.15 (95%CI: 3.24–53.29). Multivariate analysis for the association between H. pylori and ITP showed an OR of 20.44 (95%CI: 3.88–107.49) for women and 19.28 (95%CI: 2.03–183.42) for individuals over 50 years. All 29 H. pylori‐positive patients with ITP received eradication treatment. After a median follow up of 12.2 months, 80.8% had a recovery in platelet counts.
Conclusions: According to these results and others from different countries where H. pylori infection rates are high, patients with ITP should be initially tested for H. pylori status, and if present, infection should be eradicated before initiating a drastic conventional ITP treatment. An algorithm for the study and management of patients with ITP in the post‐Helicobacter era is presented.</description><identifier>ISSN: 1083-4389</identifier><identifier>EISSN: 1523-5378</identifier><identifier>EISSN: 1478-4041</identifier><identifier>DOI: 10.1111/j.1523-5378.2007.00502.x</identifier><identifier>PMID: 17493008</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>13C-urea breath test ; Adult ; Aged ; Anti-Bacterial Agents - therapeutic use ; Colombia ; Female ; Helicobacter Infections - complications ; Helicobacter Infections - drug therapy ; Helicobacter pylori ; Humans ; idiopathic thrombocytopenic purpura ; Latin America ; Male ; Middle Aged ; Purpura, Thrombocytopenic, Idiopathic - complications ; Review Literature as Topic</subject><ispartof>Helicobacter (Cambridge, Mass.), 2007-06, Vol.12 (3), p.265-273</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5012-a349b05201bfbc335dc41d891a9a3539a76d051e630a1b20821fa7936ba488e93</citedby><cites>FETCH-LOGICAL-c5012-a349b05201bfbc335dc41d891a9a3539a76d051e630a1b20821fa7936ba488e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1523-5378.2007.00502.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1523-5378.2007.00502.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17493008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campuzano-Maya, Germán</creatorcontrib><title>Proof of an Association between Helicobacter pylori and Idiopathic Thrombocytopenic Purpura in Latin America</title><title>Helicobacter (Cambridge, Mass.)</title><addtitle>Helicobacter</addtitle><description>Background: Association between Helicobacter pylori and idiopathic thrombocytopenic purpura (ITP) has been found in Japan and in some European countries. It has also been shown that eradication of H. pylori can increase platelet counts in patients with ITP. The aims of this study were to determine the prevalence of H. pylori infection in patients with ITP in Colombia, and the effect of bacterial eradication on their platelet counts.
Materials and methods: Between December 1998 and April 2006, a total of 32 patients diagnosed with ITP were included in the study. Controls were age and sex matched.
Results: H. pylori infection in patients with ITP was significantly higher (p = .00006) than in control individuals (90.6% and 43.8%, respectively), as determined by 13C‐urea breath test. A significant association between H. pylori infection and ITP was found (p < .0003), with an odds ratio (OR) of 13.15 (95%CI: 3.24–53.29). Multivariate analysis for the association between H. pylori and ITP showed an OR of 20.44 (95%CI: 3.88–107.49) for women and 19.28 (95%CI: 2.03–183.42) for individuals over 50 years. All 29 H. pylori‐positive patients with ITP received eradication treatment. After a median follow up of 12.2 months, 80.8% had a recovery in platelet counts.
Conclusions: According to these results and others from different countries where H. pylori infection rates are high, patients with ITP should be initially tested for H. pylori status, and if present, infection should be eradicated before initiating a drastic conventional ITP treatment. An algorithm for the study and management of patients with ITP in the post‐Helicobacter era is presented.</description><subject>13C-urea breath test</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Colombia</subject><subject>Female</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>idiopathic thrombocytopenic purpura</subject><subject>Latin America</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Purpura, Thrombocytopenic, Idiopathic - complications</subject><subject>Review Literature as Topic</subject><issn>1083-4389</issn><issn>1523-5378</issn><issn>1478-4041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVFv2yAUhdG0ae3a_YWJp73ZuxgwWNpLFbVJp2ht1W57RBhjlcw2Hthq8u9Llqh77BASV_Cdc9E9CGECOUnryyYnvKAZp0LmBYDIATgU-fYNOn15eJtqkDRjVFYn6EOMG0gUZdV7dEIEqyiAPEXdbfC-xWnrAV_E6I3Tk_MDru30ZO2AV7ZzxtfaTDbgcdf54BLa4OvG-VFPj87gh8fg-9qb3eRHO6SL2zmMc9DYDXid3JJxb4Mz-hy9a3UX7cfjeYZ-XF0-LFbZ-mZ5vbhYZ4YDKTKdPlkDL4DUbW0o5Y1hpJEV0ZWmnFZalA1wYksKmtQFyIK0WlS0rDWT0lb0DH0--I7B_5ltnFTvorFdpwfr56gEMAkVZ6-CBbCSMy4SKA-gCT7GYFs1BtfrsFME1D4StVH7yav95NU-EvU3ErVN0k_HHnPd2-af8JhBAr4egCfX2d1_G6vV5ToVSZ4d5C5Odvsi1-G3KgUVXP36vlQ_xeLu6v7bUt3TZwAJqVA</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>Campuzano-Maya, Germán</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200706</creationdate><title>Proof of an Association between Helicobacter pylori and Idiopathic Thrombocytopenic Purpura in Latin America</title><author>Campuzano-Maya, Germán</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5012-a349b05201bfbc335dc41d891a9a3539a76d051e630a1b20821fa7936ba488e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>13C-urea breath test</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Colombia</topic><topic>Female</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>idiopathic thrombocytopenic purpura</topic><topic>Latin America</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Purpura, Thrombocytopenic, Idiopathic - complications</topic><topic>Review Literature as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campuzano-Maya, Germán</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Helicobacter (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campuzano-Maya, Germán</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proof of an Association between Helicobacter pylori and Idiopathic Thrombocytopenic Purpura in Latin America</atitle><jtitle>Helicobacter (Cambridge, Mass.)</jtitle><addtitle>Helicobacter</addtitle><date>2007-06</date><risdate>2007</risdate><volume>12</volume><issue>3</issue><spage>265</spage><epage>273</epage><pages>265-273</pages><issn>1083-4389</issn><eissn>1523-5378</eissn><eissn>1478-4041</eissn><abstract>Background: Association between Helicobacter pylori and idiopathic thrombocytopenic purpura (ITP) has been found in Japan and in some European countries. It has also been shown that eradication of H. pylori can increase platelet counts in patients with ITP. The aims of this study were to determine the prevalence of H. pylori infection in patients with ITP in Colombia, and the effect of bacterial eradication on their platelet counts.
Materials and methods: Between December 1998 and April 2006, a total of 32 patients diagnosed with ITP were included in the study. Controls were age and sex matched.
Results: H. pylori infection in patients with ITP was significantly higher (p = .00006) than in control individuals (90.6% and 43.8%, respectively), as determined by 13C‐urea breath test. A significant association between H. pylori infection and ITP was found (p < .0003), with an odds ratio (OR) of 13.15 (95%CI: 3.24–53.29). Multivariate analysis for the association between H. pylori and ITP showed an OR of 20.44 (95%CI: 3.88–107.49) for women and 19.28 (95%CI: 2.03–183.42) for individuals over 50 years. All 29 H. pylori‐positive patients with ITP received eradication treatment. After a median follow up of 12.2 months, 80.8% had a recovery in platelet counts.
Conclusions: According to these results and others from different countries where H. pylori infection rates are high, patients with ITP should be initially tested for H. pylori status, and if present, infection should be eradicated before initiating a drastic conventional ITP treatment. An algorithm for the study and management of patients with ITP in the post‐Helicobacter era is presented.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17493008</pmid><doi>10.1111/j.1523-5378.2007.00502.x</doi><tpages>9</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | 13C-urea breath test Adult Aged Anti-Bacterial Agents - therapeutic use Colombia Female Helicobacter Infections - complications Helicobacter Infections - drug therapy Helicobacter pylori Humans idiopathic thrombocytopenic purpura Latin America Male Middle Aged Purpura, Thrombocytopenic, Idiopathic - complications Review Literature as Topic |
| title | Proof of an Association between Helicobacter pylori and Idiopathic Thrombocytopenic Purpura in Latin America |
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