Parenteral microemulsions: An overview
Parenteral delivery of the hydrophobic drugs is a very challenging task. The conventional approaches such as use of co-solvents, oily vehicles and modern approaches such as mixed micelles, liposomes, complexation with cyclodextrins and emulsions have several limitations. Microemulsions have evolved...
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| Veröffentlicht in: | International journal of pharmaceutics 2008-05, Vol.355 (1), p.19-30 |
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| container_title | International journal of pharmaceutics |
| container_volume | 355 |
| creator | Date, Abhijit A. Nagarsenker, M.S. |
| description | Parenteral delivery of the hydrophobic drugs is a very challenging task. The conventional approaches such as use of co-solvents, oily vehicles and modern approaches such as mixed micelles, liposomes, complexation with cyclodextrins and emulsions have several limitations. Microemulsions have evolved as a novel vehicle for parenteral delivery of the hydrophobic drugs. Their interesting features such as spontaneity of formation, ease of manufacture, high solubilization capacity and self-preserving property make them the vehicle of choice. The review focuses on the excipients available for formulation of the parenteral microemulsions and describes the investigations reported for the various classes of therapeutic agents. |
| doi_str_mv | 10.1016/j.ijpharm.2008.01.004 |
| format | Article |
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The conventional approaches such as use of co-solvents, oily vehicles and modern approaches such as mixed micelles, liposomes, complexation with cyclodextrins and emulsions have several limitations. Microemulsions have evolved as a novel vehicle for parenteral delivery of the hydrophobic drugs. Their interesting features such as spontaneity of formation, ease of manufacture, high solubilization capacity and self-preserving property make them the vehicle of choice. 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The conventional approaches such as use of co-solvents, oily vehicles and modern approaches such as mixed micelles, liposomes, complexation with cyclodextrins and emulsions have several limitations. Microemulsions have evolved as a novel vehicle for parenteral delivery of the hydrophobic drugs. Their interesting features such as spontaneity of formation, ease of manufacture, high solubilization capacity and self-preserving property make them the vehicle of choice. The review focuses on the excipients available for formulation of the parenteral microemulsions and describes the investigations reported for the various classes of therapeutic agents.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chemistry, Physical</subject><subject>Drug Delivery Systems</subject><subject>Emulsions - chemistry</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Hydrophobic drugs</subject><subject>Infusions, Parenteral</subject><subject>Medical sciences</subject><subject>Microemulsions</subject><subject>Nanoparticles - chemistry</subject><subject>Paclitaxel</subject><subject>Parenteral delivery</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmaceutical technology. 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Drug treatments</topic><topic>Surface-Active Agents - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Date, Abhijit A.</creatorcontrib><creatorcontrib>Nagarsenker, M.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Date, Abhijit A.</au><au>Nagarsenker, M.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parenteral microemulsions: An overview</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>355</volume><issue>1</issue><spage>19</spage><epage>30</epage><pages>19-30</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>Parenteral delivery of the hydrophobic drugs is a very challenging task. 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| fulltext | fulltext |
| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2008-05, Vol.355 (1), p.19-30 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Chemical Phenomena Chemistry, Pharmaceutical Chemistry, Physical Drug Delivery Systems Emulsions - chemistry General pharmacology Humans Hydrophobic drugs Infusions, Parenteral Medical sciences Microemulsions Nanoparticles - chemistry Paclitaxel Parenteral delivery Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Surface-Active Agents - chemistry |
| title | Parenteral microemulsions: An overview |
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