Protective immunity induced by systemic and mucosal delivery of DNA vaccine expressing glycoprotein B of pseudorabies virus

A murine model immunized by systemic and mucosal delivery of plasmid DNA vaccine expressing glycoprotein B (pCIgB) of pseudorabies virus (PrV) was used to evaluate both the nature of the induced immunity and protection against a virulent virus. With regard to systemic delivery, the intramuscular (i....

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Veröffentlicht in:	Journal of microbiology and biotechnology 2008-03, Vol.18 (3), p.591-599
Hauptverfasser:	Yoon, H.A. (Chonbuk National University, Jeonju, Republic of Korea), Han, Y.W. (Chonbuk National University, Jeonju, Republic of Korea), Aleyas, Abi George (Chonbuk National University, Jeonju, Republic of Korea), George, Junu Abi (Chonbuk National University, Jeonju, Republic of Korea), Kim, S.J. (Chonbuk National University, Jeonju, Republic of Korea), Kim, H.K. (Chonbuk National University, Jeonju, Republic of Korea), Song, H.J. (Chonbuk National University, Jeonju, Republic of Korea), Cho, J.G. (Chonbuk National University, Jeonju, Republic of Korea), Eo, S.K. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: vetvirus@chonbuk.ac.kr
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Antibodies, Viral - blood AUJESZKY VIRUS Biological and medical sciences Biotechnology Cell Line Cytokines - blood DNA vaccine Female Fundamental and applied biological sciences. Psychology Herpesvirus 1, Suid - genetics Herpesvirus 1, Suid - immunology Herpesvirus 1, Suid - pathogenicity IMMUNITE IMMUNITY Immunoglobulin A - blood Immunoglobulin A, Secretory Immunoglobulin G - blood Injections, Intramuscular INMUNIDAD Mice Mice, Inbred C57BL mucosal delivery Pseudorabies - immunology Pseudorabies - prevention & control Pseudorabies Vaccines - administration & dosage systemic delivery Th1 Cells - immunology Th2 Cells - immunology Vaccines, DNA - administration & dosage Vaccines, DNA - immunology Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology VIRUS D'AUJESZKY VIRUS DE AUJESZKY
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