The prophylactic administration of a monoclonal antibody against human metapneumovirus attenuates viral disease and airways hyperresponsiveness in mice

Human metapneumovirus (hMPV) is one of the most frequent causes of respiratory tract infections in children. Our objective was to assess the prophylactic benefit of a monoclonal antibody (mAb) against the hMPV fusion protein in a murine model. BALB/c mice received one intramuscular injection of eith...

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Veröffentlicht in:	Antiviral therapy 2008, Vol.13 (1), p.39-46
Hauptverfasser:	HAMELIN, Marie-Eve, COUTURE, Christian, SACKETT, Melanie, KIENER, Peter, SUZICH, Joann, ULBRANDT, Nancy, BAIVIN, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antiviral agents Biological and medical sciences Bronchial Hyperreactivity - complications Bronchial Hyperreactivity - drug therapy Bronchial Hyperreactivity - prevention & control Bronchial Hyperreactivity - virology Dose-Response Relationship, Drug Human metapneumovirus Infectious diseases Medical sciences Metapneumovirus - immunology Mice Paramyxoviridae Infections - drug therapy Paramyxoviridae Infections - immunology Paramyxoviridae Infections - prevention & control Paramyxoviridae Infections - virology Pharmacology. Drug treatments Viral diseases
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