Exercise training improves the antioxidant enzyme activity with no changes of telomere length
The purpose of this study was to determine the changes of both oxidant and antioxidant levels with exercise training in obese middle-aged women. The association between telomere length and oxidative stress with exercise was also examined. Sixteen obese middle-aged women participated in this study. T...
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| Veröffentlicht in: | Mechanisms of ageing and development 2008-05, Vol.129 (5), p.254-260 |
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| creator | Shin, Yun-A. Lee, Jun-Hyoup Song, Wook Jun, Tae-Won |
| description | The purpose of this study was to determine the changes of both oxidant and antioxidant levels with exercise training in obese middle-aged women. The association between telomere length and oxidative stress with exercise was also examined. Sixteen obese middle-aged women participated in this study. The subjects were randomly divided into exercise group (EX) and control group (CON). EX performed aerobic exercise training for 6 months. DNA was extracted from leukocytes in peripheral blood and their telomere lengths were measured by real time PCR analysis. Long-term exercise training decreased body weight and BMI, and increased
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. Resting levels of erythrocyte glutathione peroxidase activity were higher in EX compared to CON. Superoxide dismutase (SOD) activities were higher after the acute exercise test at mid-intensity in post-exercise training than in the pre-exercise training conditions. The telomere length did not change significantly after the acute exercise test in the pre-exercise training condition in spite of the increased level of malondialdehyde (MDA) as a marker of oxidative stress. In conclusion, antioxidant enzyme activities were increased following long-term exercise training; however, the lengths of telomere in leukocytes were not influenced by both mid-intensity and high intensity of exercise stress. |
| doi_str_mv | 10.1016/j.mad.2008.01.001 |
| format | Article |
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. Resting levels of erythrocyte glutathione peroxidase activity were higher in EX compared to CON. Superoxide dismutase (SOD) activities were higher after the acute exercise test at mid-intensity in post-exercise training than in the pre-exercise training conditions. The telomere length did not change significantly after the acute exercise test in the pre-exercise training condition in spite of the increased level of malondialdehyde (MDA) as a marker of oxidative stress. In conclusion, antioxidant enzyme activities were increased following long-term exercise training; however, the lengths of telomere in leukocytes were not influenced by both mid-intensity and high intensity of exercise stress.</description><identifier>ISSN: 0047-6374</identifier><identifier>EISSN: 1872-6216</identifier><identifier>DOI: 10.1016/j.mad.2008.01.001</identifier><identifier>PMID: 18295822</identifier><identifier>CODEN: MAGDA3</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acute exercise test ; Anthropometry ; Antioxidant enzyme activity ; Antioxidants - metabolism ; Biological and medical sciences ; Body Mass Index ; Development. Metamorphosis. Moult. Ageing ; Erythrocytes - enzymology ; Exercise - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Glutathione Peroxidase - blood ; Humans ; Long-term exercise training ; Malondialdehyde - blood ; Middle Aged ; Obesity ; Oxidative Stress ; Physical Education and Training ; Superoxide Dismutase - blood ; Telomere ; Telomere length ; Time Factors ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Mechanisms of ageing and development, 2008-05, Vol.129 (5), p.254-260</ispartof><rights>2008 Elsevier Ireland Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-5aaa615d4b1d0b10f7e610d213ef7ad9314761396678c1f4686020b2afaf24ed3</citedby><cites>FETCH-LOGICAL-c412t-5aaa615d4b1d0b10f7e610d213ef7ad9314761396678c1f4686020b2afaf24ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S004763740800002X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20256885$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18295822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Yun-A.</creatorcontrib><creatorcontrib>Lee, Jun-Hyoup</creatorcontrib><creatorcontrib>Song, Wook</creatorcontrib><creatorcontrib>Jun, Tae-Won</creatorcontrib><title>Exercise training improves the antioxidant enzyme activity with no changes of telomere length</title><title>Mechanisms of ageing and development</title><addtitle>Mech Ageing Dev</addtitle><description>The purpose of this study was to determine the changes of both oxidant and antioxidant levels with exercise training in obese middle-aged women. The association between telomere length and oxidative stress with exercise was also examined. Sixteen obese middle-aged women participated in this study. The subjects were randomly divided into exercise group (EX) and control group (CON). EX performed aerobic exercise training for 6 months. DNA was extracted from leukocytes in peripheral blood and their telomere lengths were measured by real time PCR analysis. Long-term exercise training decreased body weight and BMI, and increased
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. Resting levels of erythrocyte glutathione peroxidase activity were higher in EX compared to CON. Superoxide dismutase (SOD) activities were higher after the acute exercise test at mid-intensity in post-exercise training than in the pre-exercise training conditions. The telomere length did not change significantly after the acute exercise test in the pre-exercise training condition in spite of the increased level of malondialdehyde (MDA) as a marker of oxidative stress. In conclusion, antioxidant enzyme activities were increased following long-term exercise training; however, the lengths of telomere in leukocytes were not influenced by both mid-intensity and high intensity of exercise stress.</description><subject>Acute exercise test</subject><subject>Anthropometry</subject><subject>Antioxidant enzyme activity</subject><subject>Antioxidants - metabolism</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Development. Metamorphosis. Moult. Ageing</subject><subject>Erythrocytes - enzymology</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutathione Peroxidase - blood</subject><subject>Humans</subject><subject>Long-term exercise training</subject><subject>Malondialdehyde - blood</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Oxidative Stress</subject><subject>Physical Education and Training</subject><subject>Superoxide Dismutase - blood</subject><subject>Telomere</subject><subject>Telomere length</subject><subject>Time Factors</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0047-6374</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EGL1DAUwPEgiju7-gG8SC56a30vbdMUT7KsrrDgRY8SMsnrTIY2XZPMuOOnN8sMetPTg_B7j_Bn7BVCjYDy3a6ejasFgKoBawB8wlaoelFJgfIpWwG0fSWbvr1glyntoIhWyOfsApUYOiXEin2_eaBofSKeo_HBhw33831cDpR43hI3IfvlwbsyOYVfx7k82ewPPh_5T5-3PCzcbk3YFL-MPNO0zBSJTxQ2efuCPRvNlOjleV6xbx9vvl7fVndfPn2-_nBX2RZFrjpjjMTOtWt0sEYYe5IITmBDY2_c0GDbS2wGKXtlcWylkiBgLcxoRtGSa67Y29Pd8vMfe0pZzz5ZmiYTaNkn3ZcQChr1X4hDJ4eSrUA8QRuXlCKN-j762cSjRtCP8fVOl_j6Mb4G1CVt2Xl9Pr5fz-T-bpxrF_DmDEyyZhqjCSX9HydAdFKprrj3J0el2cFT1Ml6Cpacj2Szdov_xzd-A_njoi4</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Shin, Yun-A.</creator><creator>Lee, Jun-Hyoup</creator><creator>Song, Wook</creator><creator>Jun, Tae-Won</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080501</creationdate><title>Exercise training improves the antioxidant enzyme activity with no changes of telomere length</title><author>Shin, Yun-A. ; Lee, Jun-Hyoup ; Song, Wook ; Jun, Tae-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-5aaa615d4b1d0b10f7e610d213ef7ad9314761396678c1f4686020b2afaf24ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acute exercise test</topic><topic>Anthropometry</topic><topic>Antioxidant enzyme activity</topic><topic>Antioxidants - metabolism</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Development. Metamorphosis. Moult. Ageing</topic><topic>Erythrocytes - enzymology</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutathione Peroxidase - blood</topic><topic>Humans</topic><topic>Long-term exercise training</topic><topic>Malondialdehyde - blood</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Oxidative Stress</topic><topic>Physical Education and Training</topic><topic>Superoxide Dismutase - blood</topic><topic>Telomere</topic><topic>Telomere length</topic><topic>Time Factors</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shin, Yun-A.</creatorcontrib><creatorcontrib>Lee, Jun-Hyoup</creatorcontrib><creatorcontrib>Song, Wook</creatorcontrib><creatorcontrib>Jun, Tae-Won</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of ageing and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Yun-A.</au><au>Lee, Jun-Hyoup</au><au>Song, Wook</au><au>Jun, Tae-Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise training improves the antioxidant enzyme activity with no changes of telomere length</atitle><jtitle>Mechanisms of ageing and development</jtitle><addtitle>Mech Ageing Dev</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>129</volume><issue>5</issue><spage>254</spage><epage>260</epage><pages>254-260</pages><issn>0047-6374</issn><eissn>1872-6216</eissn><coden>MAGDA3</coden><abstract>The purpose of this study was to determine the changes of both oxidant and antioxidant levels with exercise training in obese middle-aged women. The association between telomere length and oxidative stress with exercise was also examined. Sixteen obese middle-aged women participated in this study. The subjects were randomly divided into exercise group (EX) and control group (CON). EX performed aerobic exercise training for 6 months. DNA was extracted from leukocytes in peripheral blood and their telomere lengths were measured by real time PCR analysis. Long-term exercise training decreased body weight and BMI, and increased
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O
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. Resting levels of erythrocyte glutathione peroxidase activity were higher in EX compared to CON. Superoxide dismutase (SOD) activities were higher after the acute exercise test at mid-intensity in post-exercise training than in the pre-exercise training conditions. The telomere length did not change significantly after the acute exercise test in the pre-exercise training condition in spite of the increased level of malondialdehyde (MDA) as a marker of oxidative stress. In conclusion, antioxidant enzyme activities were increased following long-term exercise training; however, the lengths of telomere in leukocytes were not influenced by both mid-intensity and high intensity of exercise stress.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18295822</pmid><doi>10.1016/j.mad.2008.01.001</doi><tpages>7</tpages></addata></record> |
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| subjects | Acute exercise test Anthropometry Antioxidant enzyme activity Antioxidants - metabolism Biological and medical sciences Body Mass Index Development. Metamorphosis. Moult. Ageing Erythrocytes - enzymology Exercise - physiology Female Fundamental and applied biological sciences. Psychology Glutathione Peroxidase - blood Humans Long-term exercise training Malondialdehyde - blood Middle Aged Obesity Oxidative Stress Physical Education and Training Superoxide Dismutase - blood Telomere Telomere length Time Factors Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Exercise training improves the antioxidant enzyme activity with no changes of telomere length |
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