THE EPIDEMIOLOGY OF VISCERAL LEISHMANIASIS AND ASYMPTOMATIC LEISHMANIAL INFECTION IN A HIGHLY ENDEMIC BANGLADESHI VILLAGE
We examined the epidemiology of kala-azar and asymptomatic leishmanial infection measured by serologic and leishmanin skin test results in a Bangladeshi community. In a subset, we measured serum retinol, zinc and C-reactive protein (CRP). Kala-azar and seroconversion incidence were 15.6 and 63.1 per...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2007-05, Vol.76 (5), p.909-914 |
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| creator | BERN, CARYN HAQUE, RASHIDUL CHOWDHURY, RAJIB ALI, MUSTAKIM KURKJIAN, KATIE M VAZ, LOUISE AMANN, JOSEF WAHED, M. A WAGATSUMA, YUKIKO BREIMAN, ROBERT F WILLIAMSON, JOHN SECOR, W. EVAN MAGUIRE, JAMES H |
| description | We examined the epidemiology of kala-azar and asymptomatic leishmanial infection measured by serologic and leishmanin skin test results in a Bangladeshi community. In a subset, we measured serum retinol, zinc and C-reactive protein (CRP). Kala-azar and seroconversion incidence were 15.6 and 63.1 per 1,000 person-years, respectively. Proximity to a previous kala-azar case increased the likelihood of both kala-azar and asymptomatic infection. Bed net use protected against kala-azar (rate ratio = 0.35, P < 0.01), but not subclinical infection (rate ratio = 1.1, P = 0.82). Kala-azar patients were younger (P < 0.001) and reported lower red meat consumption (P < 0.01) than asymptomatic seropositive individuals. Retinol and zinc levels were lower in current kala-azar patients and those who later developed kala-azar compared with uninfected and asymptomatically infected subjects. The CRP levels were higher in kala-azar patients compared with the other two groups. Low red meat intake and poor zinc and retinol status may characterize a group at higher risk of symptomatic disease. |
| doi_str_mv | 10.4269/ajtmh.2007.76.909 |
| format | Article |
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Kala-azar patients were younger (P < 0.001) and reported lower red meat consumption (P < 0.01) than asymptomatic seropositive individuals. Retinol and zinc levels were lower in current kala-azar patients and those who later developed kala-azar compared with uninfected and asymptomatically infected subjects. The CRP levels were higher in kala-azar patients compared with the other two groups. Low red meat intake and poor zinc and retinol status may characterize a group at higher risk of symptomatic disease.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.2007.76.909</identifier><identifier>PMID: 17488915</identifier><identifier>CODEN: AJTHAB</identifier><language>eng</language><publisher>Lawrence, KS: ASTMH</publisher><subject>Adult ; Antibodies, Protozoan - analysis ; Antibodies, Protozoan - metabolism ; Antigens, Protozoan - metabolism ; Bangladesh - epidemiology ; Biological and medical sciences ; C-Reactive Protein - analysis ; Child ; Child, Preschool ; Endemic Diseases - statistics & numerical data ; Human protozoal diseases ; Humans ; Incidence ; Infectious diseases ; Leishmaniasis, Visceral - diagnosis ; Leishmaniasis, Visceral - epidemiology ; Leshmaniasis ; Logistic Models ; Medical sciences ; Parasitic diseases ; Poisson Distribution ; Prevalence ; Protozoal diseases ; Protozoan Proteins - metabolism ; Risk Factors ; Time Factors ; Vitamin A - blood ; Zinc - blood</subject><ispartof>The American journal of tropical medicine and hygiene, 2007-05, Vol.76 (5), p.909-914</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-48309375ccbc6696d6897cdb52c952f714c05feae47e660ae2a4b0d897869ba73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18755892$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17488915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BERN, CARYN</creatorcontrib><creatorcontrib>HAQUE, RASHIDUL</creatorcontrib><creatorcontrib>CHOWDHURY, RAJIB</creatorcontrib><creatorcontrib>ALI, MUSTAKIM</creatorcontrib><creatorcontrib>KURKJIAN, KATIE M</creatorcontrib><creatorcontrib>VAZ, LOUISE</creatorcontrib><creatorcontrib>AMANN, JOSEF</creatorcontrib><creatorcontrib>WAHED, M. 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Bed net use protected against kala-azar (rate ratio = 0.35, P < 0.01), but not subclinical infection (rate ratio = 1.1, P = 0.82). Kala-azar patients were younger (P < 0.001) and reported lower red meat consumption (P < 0.01) than asymptomatic seropositive individuals. Retinol and zinc levels were lower in current kala-azar patients and those who later developed kala-azar compared with uninfected and asymptomatically infected subjects. The CRP levels were higher in kala-azar patients compared with the other two groups. Low red meat intake and poor zinc and retinol status may characterize a group at higher risk of symptomatic disease.</description><subject>Adult</subject><subject>Antibodies, Protozoan - analysis</subject><subject>Antibodies, Protozoan - metabolism</subject><subject>Antigens, Protozoan - metabolism</subject><subject>Bangladesh - epidemiology</subject><subject>Biological and medical sciences</subject><subject>C-Reactive Protein - analysis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Endemic Diseases - statistics & numerical data</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infectious diseases</subject><subject>Leishmaniasis, Visceral - diagnosis</subject><subject>Leishmaniasis, Visceral - epidemiology</subject><subject>Leshmaniasis</subject><subject>Logistic Models</subject><subject>Medical sciences</subject><subject>Parasitic diseases</subject><subject>Poisson Distribution</subject><subject>Prevalence</subject><subject>Protozoal diseases</subject><subject>Protozoan Proteins - metabolism</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Vitamin A - blood</subject><subject>Zinc - blood</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v0zAYgC0EYmXwA7ggX-CWYif-iI8mTRtLaTKRgNST5bgOzZSsW9yq2r8n3SqVGydb8vM-r6UHgM8YzUnIxHdzfxh28xAhPudsLpB4A2aYcBZgRuhbMEMIhYFgEb8BH7y_RwjHIcbvwQ3mJI4FpjPwXGcpTO_UIl2rMi9XG1gu4W9VJelPmcM8VVW2loWSlaqgLBZQVpv1XV2uZa2Sf55zqIplmtSqLKYblDBTqyzfwLQ4ixP4QxarXC7SKlOTPc_lKv0I3rWm9-7T5bwFv5ZpnWTB9AuVyDywJIoOAYkjJCJOrW0sY4JtWSy43TY0tIKGLcfEIto64wh3jCHjQkMatJ2gmInG8OgWfHv1Po77p6PzBz103rq-Nw9uf_SaI8KJoOK_YIhIyCNKJhC_gnbcez-6Vj-O3WDGZ42RPofRL2H0OYzmTE9hppkvF_mxGdz2OnEpMQFfL4Dx1vTtaB5s569czCmNRXjldt2f3akbnfaD6ftJi_XpdJrW0ZeFfwGtk5mi</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>BERN, CARYN</creator><creator>HAQUE, RASHIDUL</creator><creator>CHOWDHURY, RAJIB</creator><creator>ALI, MUSTAKIM</creator><creator>KURKJIAN, KATIE M</creator><creator>VAZ, LOUISE</creator><creator>AMANN, JOSEF</creator><creator>WAHED, M. 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EVAN</au><au>MAGUIRE, JAMES H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THE EPIDEMIOLOGY OF VISCERAL LEISHMANIASIS AND ASYMPTOMATIC LEISHMANIAL INFECTION IN A HIGHLY ENDEMIC BANGLADESHI VILLAGE</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>76</volume><issue>5</issue><spage>909</spage><epage>914</epage><pages>909-914</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>We examined the epidemiology of kala-azar and asymptomatic leishmanial infection measured by serologic and leishmanin skin test results in a Bangladeshi community. In a subset, we measured serum retinol, zinc and C-reactive protein (CRP). Kala-azar and seroconversion incidence were 15.6 and 63.1 per 1,000 person-years, respectively. Proximity to a previous kala-azar case increased the likelihood of both kala-azar and asymptomatic infection. Bed net use protected against kala-azar (rate ratio = 0.35, P < 0.01), but not subclinical infection (rate ratio = 1.1, P = 0.82). Kala-azar patients were younger (P < 0.001) and reported lower red meat consumption (P < 0.01) than asymptomatic seropositive individuals. Retinol and zinc levels were lower in current kala-azar patients and those who later developed kala-azar compared with uninfected and asymptomatically infected subjects. The CRP levels were higher in kala-azar patients compared with the other two groups. Low red meat intake and poor zinc and retinol status may characterize a group at higher risk of symptomatic disease.</abstract><cop>Lawrence, KS</cop><pub>ASTMH</pub><pmid>17488915</pmid><doi>10.4269/ajtmh.2007.76.909</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Antibodies, Protozoan - analysis Antibodies, Protozoan - metabolism Antigens, Protozoan - metabolism Bangladesh - epidemiology Biological and medical sciences C-Reactive Protein - analysis Child Child, Preschool Endemic Diseases - statistics & numerical data Human protozoal diseases Humans Incidence Infectious diseases Leishmaniasis, Visceral - diagnosis Leishmaniasis, Visceral - epidemiology Leshmaniasis Logistic Models Medical sciences Parasitic diseases Poisson Distribution Prevalence Protozoal diseases Protozoan Proteins - metabolism Risk Factors Time Factors Vitamin A - blood Zinc - blood |
| title | THE EPIDEMIOLOGY OF VISCERAL LEISHMANIASIS AND ASYMPTOMATIC LEISHMANIAL INFECTION IN A HIGHLY ENDEMIC BANGLADESHI VILLAGE |
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