A review of cis-trans interplay between DNA sequences 5' to the (G)gamma- and beta-globin genes among Hb F-Malta-I heterozygotes/homozygotes and beta-thalassemia homozygotes/compound heterozygotes, and the effects of hydroxyurea on the Hb F/F-erythrocyte; the need for large multicenter trials

The biosynthesis of Hb F in place of the deficient Hb A could be a suitable treatment for beta hemoglobinopathies. Among newborn Hb F-Malta-I heterozygotes, it could be shown that the XmnI sequence alone had little, if any effect on gamma-globin gene expression, but interplay with the (AT)(X)T(Y) si...

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Veröffentlicht in:	Hemoglobin 2007, Vol.31 (2), p.279-288
Hauptverfasser:	Felice, Alex E, Borg, Joseph, Pizzuto, Monica, Cassar, Wilhelmina, Galdies, Ruth, Wettinger, Stephanie Bezzina, Pulis, Svetlana, Hunter, Gary J, Caruana, Mary R, Farrugia, Mario, Scerri, Christian A
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Thalassemia - blood beta-Thalassemia - genetics DNA - blood DNA - genetics DNA - isolation & purification Erythrocytes - drug effects Erythrocytes - physiology Fetal Hemoglobin - genetics Genetic Carrier Screening Globins - genetics Homozygote Humans Hydroxyurea - pharmacology Malta Mutation
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