The outcome of infants younger than 6 months requiring ventilation for pneumonia caused by Mycobacterium tuberculosis
Introduction The outcome of young infants (
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| Veröffentlicht in: | Pediatric pulmonology 2008-05, Vol.43 (5), p.505-510 |
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| creator | Goussard, P. Gie, R.P. Kling, S. Schaaf, H.S. Kritzinger, F. Andronikou, S. Beyers, N. Rossouw, G.J. |
| description | Introduction
The outcome of young infants ( |
| doi_str_mv | 10.1002/ppul.20812 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70473319</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70473319</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3952-40e85b98654d51f70a38c7c158b3c0841929125c029e557b01b319d27b7cd4573</originalsourceid><addsrcrecordid>eNp90Mtu1DAUBmALgei0sOEBkDewqJTiSxzbS1TBcJmBLlohsbEcx-kYEjv1Bcjbk2GGsmN1Fv7-c6wfgGcYXWCEyKtpKsMFQQKTB2CFkZQVqmXzEKwEZ6xqRENPwGlK3xBa3iR-DE6woIJi3KxAud5ZGEo2YVxmD53vtc8JzqH4Wxth3mkPGzgGn3cJRntXXHT-Fv6wPrtBZxc87EOEk7dlQU5Do0uyHWxnuJ1NaLXJNroywlxaG00ZQnLpCXjU6yHZp8d5Bm7evrm-fFdtPq_fX77eVIZKRqoaWcFaKRpWdwz3HGkqDDeYiZYaJGosicSEGUSkZYy3CLcUy47wlpuuZpyegZeHvVMMd8WmrEaXjB0G7W0oSXFUc7pEFnh-gCaGlKLt1RTdqOOsMFL7ktW-ZPWn5AU_P24t7Wi7f_TY6gJeHIFORg991N64dO8IIpxLsf8ePrifbrDzf06qq6ubzd_j1SHjUra_7jM6flcNp5ypL5_W6sN683Wz3TbqI_0NUSmk6Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70473319</pqid></control><display><type>article</type><title>The outcome of infants younger than 6 months requiring ventilation for pneumonia caused by Mycobacterium tuberculosis</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Goussard, P. ; Gie, R.P. ; Kling, S. ; Schaaf, H.S. ; Kritzinger, F. ; Andronikou, S. ; Beyers, N. ; Rossouw, G.J.</creator><creatorcontrib>Goussard, P. ; Gie, R.P. ; Kling, S. ; Schaaf, H.S. ; Kritzinger, F. ; Andronikou, S. ; Beyers, N. ; Rossouw, G.J.</creatorcontrib><description>Introduction
The outcome of young infants (<6 months) being ventilated for respiratory failure caused by Mycobacterium tuberculosis (MTB) has not been recorded.
Patients and Methods
A descriptive study of children <6 months admitted to the PICU from 1 February 1999 to 31 December 2005 with MTB causing respiratory failure.
Results
Seventeen infants were ventilated for respiratory failure caused by MTB: ten had ventilatory respiratory failure and seven had hypoxic failure. An index case was found in 47%. All chest radiographs (CXRs) were highly suggestive of tuberculosis. MTB was cultured in 15 cases. In the other two cases MTB was confirmed by histopathology. The median duration of ventilation was 6 days (range: 1–35 days) with a median PaO2/FiO2 of 85 and ventilatory index of 58. Transthoracic glandular enucleation was required to facilitate extubation in six babies. All the infants survived. At 6‐month follow‐up 35% had a normal CXR and all were asymptomatic. One child had CXR changes suggestive of bronchiectasis but was asymptomatic.
Conclusion
The outcome of infants <6 months ventilated for respiratory failure caused by MTB is very good if TB is recognized timeously and appropriate management started. The diagnosis of TB in these infants can be made with a high index of suspicion and careful evaluation of the CXR. Pediatr Pulmonol. 2008; 43:505–510. © 2008 Wiley‐Liss, Inc.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.20812</identifier><identifier>PMID: 18383116</identifier><identifier>CODEN: PEPUES</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Bacterial diseases ; Biological and medical sciences ; Bronchiectasis - diagnostic imaging ; Bronchiectasis - etiology ; Bronchoscopy ; Female ; Follow-Up Studies ; General aspects ; Human bacterial diseases ; Humans ; Infant ; infant tuberculosis ; Infectious diseases ; Length of Stay ; Lung - diagnostic imaging ; Lung - surgery ; Male ; Medical sciences ; Mycobacterium tuberculosis - isolation & purification ; Pneumology ; Pneumonia - complications ; Pneumonia - microbiology ; Pneumonia - therapy ; Respiration, Artificial - methods ; Respiratory Insufficiency - microbiology ; Respiratory Insufficiency - therapy ; Respiratory system : syndromes and miscellaneous diseases ; Tomography, X-Ray Computed ; Treatment Outcome ; tuberculosis ; Tuberculosis - complications ; Tuberculosis - diagnosis ; Tuberculosis - drug therapy ; Tuberculosis and atypical mycobacterial infections ; tuberculous pneumonia ; ventilation</subject><ispartof>Pediatric pulmonology, 2008-05, Vol.43 (5), p.505-510</ispartof><rights>Copyright © 2008 Wiley‐Liss, Inc.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright 2008 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3952-40e85b98654d51f70a38c7c158b3c0841929125c029e557b01b319d27b7cd4573</citedby><cites>FETCH-LOGICAL-c3952-40e85b98654d51f70a38c7c158b3c0841929125c029e557b01b319d27b7cd4573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.20812$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.20812$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20277987$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18383116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goussard, P.</creatorcontrib><creatorcontrib>Gie, R.P.</creatorcontrib><creatorcontrib>Kling, S.</creatorcontrib><creatorcontrib>Schaaf, H.S.</creatorcontrib><creatorcontrib>Kritzinger, F.</creatorcontrib><creatorcontrib>Andronikou, S.</creatorcontrib><creatorcontrib>Beyers, N.</creatorcontrib><creatorcontrib>Rossouw, G.J.</creatorcontrib><title>The outcome of infants younger than 6 months requiring ventilation for pneumonia caused by Mycobacterium tuberculosis</title><title>Pediatric pulmonology</title><addtitle>Pediatr. Pulmonol</addtitle><description>Introduction
The outcome of young infants (<6 months) being ventilated for respiratory failure caused by Mycobacterium tuberculosis (MTB) has not been recorded.
Patients and Methods
A descriptive study of children <6 months admitted to the PICU from 1 February 1999 to 31 December 2005 with MTB causing respiratory failure.
Results
Seventeen infants were ventilated for respiratory failure caused by MTB: ten had ventilatory respiratory failure and seven had hypoxic failure. An index case was found in 47%. All chest radiographs (CXRs) were highly suggestive of tuberculosis. MTB was cultured in 15 cases. In the other two cases MTB was confirmed by histopathology. The median duration of ventilation was 6 days (range: 1–35 days) with a median PaO2/FiO2 of 85 and ventilatory index of 58. Transthoracic glandular enucleation was required to facilitate extubation in six babies. All the infants survived. At 6‐month follow‐up 35% had a normal CXR and all were asymptomatic. One child had CXR changes suggestive of bronchiectasis but was asymptomatic.
Conclusion
The outcome of infants <6 months ventilated for respiratory failure caused by MTB is very good if TB is recognized timeously and appropriate management started. The diagnosis of TB in these infants can be made with a high index of suspicion and careful evaluation of the CXR. Pediatr Pulmonol. 2008; 43:505–510. © 2008 Wiley‐Liss, Inc.</description><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Bronchiectasis - diagnostic imaging</subject><subject>Bronchiectasis - etiology</subject><subject>Bronchoscopy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>infant tuberculosis</subject><subject>Infectious diseases</subject><subject>Length of Stay</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Pneumology</subject><subject>Pneumonia - complications</subject><subject>Pneumonia - microbiology</subject><subject>Pneumonia - therapy</subject><subject>Respiration, Artificial - methods</subject><subject>Respiratory Insufficiency - microbiology</subject><subject>Respiratory Insufficiency - therapy</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><subject>tuberculosis</subject><subject>Tuberculosis - complications</subject><subject>Tuberculosis - diagnosis</subject><subject>Tuberculosis - drug therapy</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>tuberculous pneumonia</subject><subject>ventilation</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90Mtu1DAUBmALgei0sOEBkDewqJTiSxzbS1TBcJmBLlohsbEcx-kYEjv1Bcjbk2GGsmN1Fv7-c6wfgGcYXWCEyKtpKsMFQQKTB2CFkZQVqmXzEKwEZ6xqRENPwGlK3xBa3iR-DE6woIJi3KxAud5ZGEo2YVxmD53vtc8JzqH4Wxth3mkPGzgGn3cJRntXXHT-Fv6wPrtBZxc87EOEk7dlQU5Do0uyHWxnuJ1NaLXJNroywlxaG00ZQnLpCXjU6yHZp8d5Bm7evrm-fFdtPq_fX77eVIZKRqoaWcFaKRpWdwz3HGkqDDeYiZYaJGosicSEGUSkZYy3CLcUy47wlpuuZpyegZeHvVMMd8WmrEaXjB0G7W0oSXFUc7pEFnh-gCaGlKLt1RTdqOOsMFL7ktW-ZPWn5AU_P24t7Wi7f_TY6gJeHIFORg991N64dO8IIpxLsf8ePrifbrDzf06qq6ubzd_j1SHjUra_7jM6flcNp5ypL5_W6sN683Wz3TbqI_0NUSmk6Q</recordid><startdate>200805</startdate><enddate>200805</enddate><creator>Goussard, P.</creator><creator>Gie, R.P.</creator><creator>Kling, S.</creator><creator>Schaaf, H.S.</creator><creator>Kritzinger, F.</creator><creator>Andronikou, S.</creator><creator>Beyers, N.</creator><creator>Rossouw, G.J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200805</creationdate><title>The outcome of infants younger than 6 months requiring ventilation for pneumonia caused by Mycobacterium tuberculosis</title><author>Goussard, P. ; Gie, R.P. ; Kling, S. ; Schaaf, H.S. ; Kritzinger, F. ; Andronikou, S. ; Beyers, N. ; Rossouw, G.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3952-40e85b98654d51f70a38c7c158b3c0841929125c029e557b01b319d27b7cd4573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Bronchiectasis - diagnostic imaging</topic><topic>Bronchiectasis - etiology</topic><topic>Bronchoscopy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>infant tuberculosis</topic><topic>Infectious diseases</topic><topic>Length of Stay</topic><topic>Lung - diagnostic imaging</topic><topic>Lung - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mycobacterium tuberculosis - isolation & purification</topic><topic>Pneumology</topic><topic>Pneumonia - complications</topic><topic>Pneumonia - microbiology</topic><topic>Pneumonia - therapy</topic><topic>Respiration, Artificial - methods</topic><topic>Respiratory Insufficiency - microbiology</topic><topic>Respiratory Insufficiency - therapy</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><topic>tuberculosis</topic><topic>Tuberculosis - complications</topic><topic>Tuberculosis - diagnosis</topic><topic>Tuberculosis - drug therapy</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>tuberculous pneumonia</topic><topic>ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goussard, P.</creatorcontrib><creatorcontrib>Gie, R.P.</creatorcontrib><creatorcontrib>Kling, S.</creatorcontrib><creatorcontrib>Schaaf, H.S.</creatorcontrib><creatorcontrib>Kritzinger, F.</creatorcontrib><creatorcontrib>Andronikou, S.</creatorcontrib><creatorcontrib>Beyers, N.</creatorcontrib><creatorcontrib>Rossouw, G.J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goussard, P.</au><au>Gie, R.P.</au><au>Kling, S.</au><au>Schaaf, H.S.</au><au>Kritzinger, F.</au><au>Andronikou, S.</au><au>Beyers, N.</au><au>Rossouw, G.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The outcome of infants younger than 6 months requiring ventilation for pneumonia caused by Mycobacterium tuberculosis</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr. Pulmonol</addtitle><date>2008-05</date><risdate>2008</risdate><volume>43</volume><issue>5</issue><spage>505</spage><epage>510</epage><pages>505-510</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><coden>PEPUES</coden><abstract>Introduction
The outcome of young infants (<6 months) being ventilated for respiratory failure caused by Mycobacterium tuberculosis (MTB) has not been recorded.
Patients and Methods
A descriptive study of children <6 months admitted to the PICU from 1 February 1999 to 31 December 2005 with MTB causing respiratory failure.
Results
Seventeen infants were ventilated for respiratory failure caused by MTB: ten had ventilatory respiratory failure and seven had hypoxic failure. An index case was found in 47%. All chest radiographs (CXRs) were highly suggestive of tuberculosis. MTB was cultured in 15 cases. In the other two cases MTB was confirmed by histopathology. The median duration of ventilation was 6 days (range: 1–35 days) with a median PaO2/FiO2 of 85 and ventilatory index of 58. Transthoracic glandular enucleation was required to facilitate extubation in six babies. All the infants survived. At 6‐month follow‐up 35% had a normal CXR and all were asymptomatic. One child had CXR changes suggestive of bronchiectasis but was asymptomatic.
Conclusion
The outcome of infants <6 months ventilated for respiratory failure caused by MTB is very good if TB is recognized timeously and appropriate management started. The diagnosis of TB in these infants can be made with a high index of suspicion and careful evaluation of the CXR. Pediatr Pulmonol. 2008; 43:505–510. © 2008 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>18383116</pmid><doi>10.1002/ppul.20812</doi><tpages>6</tpages></addata></record> |
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| subjects | Bacterial diseases Biological and medical sciences Bronchiectasis - diagnostic imaging Bronchiectasis - etiology Bronchoscopy Female Follow-Up Studies General aspects Human bacterial diseases Humans Infant infant tuberculosis Infectious diseases Length of Stay Lung - diagnostic imaging Lung - surgery Male Medical sciences Mycobacterium tuberculosis - isolation & purification Pneumology Pneumonia - complications Pneumonia - microbiology Pneumonia - therapy Respiration, Artificial - methods Respiratory Insufficiency - microbiology Respiratory Insufficiency - therapy Respiratory system : syndromes and miscellaneous diseases Tomography, X-Ray Computed Treatment Outcome tuberculosis Tuberculosis - complications Tuberculosis - diagnosis Tuberculosis - drug therapy Tuberculosis and atypical mycobacterial infections tuberculous pneumonia ventilation |
| title | The outcome of infants younger than 6 months requiring ventilation for pneumonia caused by Mycobacterium tuberculosis |
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