Cervical screening in the 21st century: the case for human papillomavirus testing of self-collected specimens
Cervical screening by Pap smear involves a high rate of false negatives, necessitating frequent testing. Because women do not like the sampling procedure, many avoid being screened. Testing for the causative high-risk human papillomavirus (HPV) types, by PCR or other technologies, on self-collected...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2007-01, Vol.45 (5), p.577-591 |
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| container_title | Clinical chemistry and laboratory medicine |
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| creator | Morris, Brian J. Rose, Barbara R. |
| description | Cervical screening by Pap smear involves a high rate of false negatives, necessitating frequent testing. Because women do not like the sampling procedure, many avoid being screened. Testing for the causative high-risk human papillomavirus (HPV) types, by PCR or other technologies, on self-collected (tampon) samples permits women to be monitored non-invasively. The high negative predictive value of HPV testing means a greater interval between tests, and thus reduces costs. HPV testing lends itself to primary screening. A kit for self-collection and return to a testing laboratory, followed by practitioner notification and follow-up if required, should result in wider participation. The higher accuracy of HPV testing should lead to improved cervical cancer prevention. Clin Chem Lab Med 2007;45:577–91. |
| doi_str_mv | 10.1515/CCLM.2007.127 |
| format | Article |
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Clin Chem Lab Med 2007;45:577–91.</description><subject>Biological and medical sciences</subject><subject>cervical cancer</subject><subject>cervical screening</subject><subject>Female</subject><subject>General aspects</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>hybrid capture</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Mass Screening - methods</subject><subject>Medical sciences</subject><subject>Papillomaviridae - isolation & purification</subject><subject>polymerase chain reaction</subject><subject>Predictive Value of Tests</subject><subject>Self-Examination</subject><subject>Specimen Handling - methods</subject><subject>specimen self-collection</subject><subject>tampon</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><issn>1437-4331</issn><issn>1434-6621</issn><issn>1434-6621</issn><issn>1437-4331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctv1DAQhy0EoqVw5Ip8gVsW2_Er3FAEbaVFCFRUbpbjHVOD88CTVPS_J9uu2COnGc188_wR8pKzDVdcvW3b7aeNYMxsuDCPyCmXtay0FvzxvW8qWdf8hDxD_MkYV0qap-SEG2ml5uaU9C2U2xR8phgKwJCGHzQNdL4BKjjONMAwL-Xu3X0keAQax0Jvlt4PdPJTynns_W0qC9IZcN6Xj5Ei5FiFMWcIM-woThBSDwM-J0-izwgvDvaMfPv44aq9qLafzy_b99sq1A2bKxW7ztQRoPONZVYqI3ZRKxl5o3ddsFFJkLFjignVdJrbKAOLTYi68T6sV5-RNw99pzL-Xta9XJ8wQM5-gHFBZ5g0wmjxX1Aww1SjmhWsHsBQRsQC0U0l9b7cOc7cXgi3F8LthXCrECv_6tB46XrYHenD51fg9QHwuL4_Fj-EhEfOGqutEMfBCWf48y_vyy-nTW2U-3Il3fnX77a9vpaurf8CDB-gxw</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Morris, Brian J.</creator><creator>Rose, Barbara R.</creator><general>Walter de Gruyter</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Cervical screening in the 21st century: the case for human papillomavirus testing of self-collected specimens</title><author>Morris, Brian J. ; Rose, Barbara R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-5fbb73feeba98084572df654f196dbc8f54e4fb050259b618f4c0f9cf69aac143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>cervical cancer</topic><topic>cervical screening</topic><topic>Female</topic><topic>General aspects</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>hybrid capture</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Mass Screening - methods</topic><topic>Medical sciences</topic><topic>Papillomaviridae - isolation & purification</topic><topic>polymerase chain reaction</topic><topic>Predictive Value of Tests</topic><topic>Self-Examination</topic><topic>Specimen Handling - methods</topic><topic>specimen self-collection</topic><topic>tampon</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morris, Brian J.</creatorcontrib><creatorcontrib>Rose, Barbara R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry and laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morris, Brian J.</au><au>Rose, Barbara R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cervical screening in the 21st century: the case for human papillomavirus testing of self-collected specimens</atitle><jtitle>Clinical chemistry and laboratory medicine</jtitle><addtitle>Clinical Chemical Laboratory Medicine</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>45</volume><issue>5</issue><spage>577</spage><epage>591</epage><pages>577-591</pages><issn>1437-4331</issn><issn>1434-6621</issn><eissn>1434-6621</eissn><eissn>1437-4331</eissn><abstract>Cervical screening by Pap smear involves a high rate of false negatives, necessitating frequent testing. 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| fulltext | fulltext |
| identifier | ISSN: 1437-4331 |
| ispartof | Clinical chemistry and laboratory medicine, 2007-01, Vol.45 (5), p.577-591 |
| issn | 1437-4331 1434-6621 1434-6621 1437-4331 |
| language | eng |
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| source | MEDLINE; De Gruyter journals |
| subjects | Biological and medical sciences cervical cancer cervical screening Female General aspects Human papillomavirus Humans hybrid capture Investigative techniques, diagnostic techniques (general aspects) Mass Screening - methods Medical sciences Papillomaviridae - isolation & purification polymerase chain reaction Predictive Value of Tests Self-Examination Specimen Handling - methods specimen self-collection tampon Uterine Cervical Neoplasms - diagnosis |
| title | Cervical screening in the 21st century: the case for human papillomavirus testing of self-collected specimens |
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