Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells

Aims/hypothesis We explored the potential adverse effects of pro-atherogenic oxidised LDL-cholesterol particles on beta cell function. Materials and methods Isolated human and rat islets and different insulin-secreting cell lines were incubated with human oxidised LDL with or without HDL particles....

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Veröffentlicht in:	Diabetologia 2007-06, Vol.50 (6), p.1304-1314
Hauptverfasser:	Abderrahmani, A, Niederhauser, G, Favre, D, Abdelli, S, Ferdaoussi, M, Yang, J. Y, Regazzi, R, Widmann, C, Waeber, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Cell Line Cells Cholesterol Diabetes Diabetes Mellitus - enzymology Diabetes. Impaired glucose tolerance Disease Progression Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme Activation Etiopathogenesis. Screening. Investigations. Target tissue resistance Genes, Reporter HDL High density lipoprotein Humans Insulin Insulin - genetics Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - enzymology Insulin-Secreting Cells - pathology islets of Langerhans JNK pathway Kinases Lipoproteins, HDL - pharmacology Lipoproteins, LDL - pharmacology Low density lipoprotein Male MAP Kinase Kinase 4 - antagonists & inhibitors MAP Kinase Kinase 4 - metabolism MAPK Medical sciences Oxidation Oxidative stress Oxidised LDL Polymerase Chain Reaction Promoter Regions, Genetic Proteins Rats Rats, Sprague-Dawley RNA - genetics RNA - isolation & purification
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