Spurious Genetic Associations

Background Genetic association studies are widely used in biomedical research and yet only a minority of positive findings stand the test of replication. I explored the capacity of association studies to produce false positive findings and the impact of various definitions of replication. Methods Ge...

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Veröffentlicht in:	Biological psychiatry (1969) 2007-05, Vol.61 (10), p.1121-1126
1. Verfasser:	Sullivan, Patrick F
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biological and medical sciences Catechol O-Methyltransferase - genetics COMT Gene Frequency genetic association study Genotype Haplotypes Humans Linkage Disequilibrium Medical sciences Models, Genetic multiple comparisons Phenotype Polymorphism, Single Nucleotide - genetics Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry replication Reproducibility of Results Schizophrenia - diagnosis Schizophrenia - genetics Schizophrenic Psychology simulation study type 1 error
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