Selection and validation of optimal siRNA target sites for RNAi-mediated gene silencing

RNA interference (RNAi)-mediated gene silencing has become a valuable tool for functional studies, reverse genomics, and drug discoveries. One major challenge of using RNAi is to identify the most effective short interfering RNAs (siRNAs) sites of a given gene. Although several published bioinformat...

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Veröffentlicht in:	Gene 2007-06, Vol.395 (1), p.160-169
Hauptverfasser:	Luo, Qing, Kang, Quan, Song, Wen-Xin, Luu, Hue H., Luo, Xiaoji, An, Naili, Luo, Jinyong, Deng, Zhong-Liang, Jiang, Wei, Yin, Hong, Chen, Jin, Sharff, Katie A., Tang, Ni, Bennett, Erwin, Haydon, Rex C., He, Tong-Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence beta Catenin - genetics Beta-catenin signaling Binding Sites - genetics Cell Line DNA - genetics Expression knockdown Gene Expression Genes, Reporter Genetic Techniques Genetic Vectors Green Fluorescent Proteins - genetics Humans Promoter Regions, Genetic Recombinant Proteins - genetics RNA Interference RNA, Small Interfering - genetics Short interfering RNA Transfection Wnt signaling
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