Direct solid-phase synthesis and fluorescence labeling of large, monodisperse mannosylated dendrons in a peptide synthesizer

Fluorophore-labeled glycodendrimers have potential use in the study of carbohydrate-protein interactions by fluorescence spectroscopy and imaging methods. The current solution-phase methods for preparation of such glycoconjugates are labour intensive. On the other hand, the intrinsically more effici...

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Veröffentlicht in:	Organic & biomolecular chemistry 2008-01, Vol.6 (8), p.1377-1385
Hauptverfasser:	Kantchev, Eric Assen B, Chang, Chung-Chieh, Cheng, Shu-Fang, Roche, Annie-Claude, Chang, Ding-Kwo
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, High Pressure Liquid - methods Combinatorial Chemistry Techniques Dendrimers - chemical synthesis Dendrimers - chemistry Fluorescence Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Glycoconjugates - chemical synthesis Glycoconjugates - chemistry Molecular Structure Peptides - chemical synthesis Peptides - chemistry Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Staining and Labeling Time Factors
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