miRNA analysis in B-cell chronic lymphocytic leukaemia: proliferation centres characterized by low miR-150 and high BIC/miR-155 expression

Several miRNAs have been reported to be associated with immunoglobulin heavy chain (IgH) mutation and ZAP-70 expression status in blood samples of B-cell chronic lymphocytic leukaemia/small lymphocytic lymphoma (B-CLL/SLL). In the bone marrow and lymphoid tissues, proliferation centres (PCs) represe...

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Veröffentlicht in:	The Journal of pathology 2008-05, Vol.215 (1), p.13-20
Hauptverfasser:	Wang, M, Tan, LP, Dijkstra, MK, van Lom, K, Robertus, J.L, Harms, G, Blokzijl, T, Kooistra, K, van t'Veer, MB, Rosati, S, Visser, L, Jongen-Lavrencic, M, Kluin, PM, van den Berg, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Proliferation Chi-Square Distribution CLL Gene Expression Genes, Immunoglobulin Humans IgH mutation Immunoglobulin Heavy Chains - genetics Immunohistochemistry In Situ Hybridization - methods Leukemia, B-Cell - genetics Leukemia, B-Cell - metabolism Leukemia, B-Cell - pathology Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymph Nodes - chemistry Lymph Nodes - pathology MicroRNAs - blood MicroRNAs - genetics miRNA Mutation proliferation centres Reverse Transcriptase Polymerase Chain Reaction ZAP-70 ZAP-70 Protein-Tyrosine Kinase - analysis ZAP-70 Protein-Tyrosine Kinase - blood
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