NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils

Antineutrophil cytoplasmic antibodies (ANCAs) with specificity for proteinase 3 (PR3) are central to a form of ANCA-associated vasculitis. Membrane PR3 (mPR3) is expressed only on a subset of neutrophils. The aim of this study was to determine the mechanism of PR3 surface expression on human neutrop...

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Veröffentlicht in:	Blood 2007-05, Vol.109 (10), p.4487-4493
Hauptverfasser:	von Vietinghoff, Sibylle, Tunnemann, Gisela, Eulenberg, Claudia, Wellner, Maren, Cristina Cardoso, M., Luft, Friedrich C., Kettritz, Ralph
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Antineutrophil Cytoplasmic - immunology Antigens, Surface - metabolism Biological and medical sciences Cell Membrane - metabolism Cells, Cultured Fetal Blood - cytology Glycosylphosphatidylinositols - metabolism GPI-Linked Proteins Hematologic and hematopoietic diseases Hematopoietic Stem Cells - metabolism Humans Immunoprecipitation In Vitro Techniques Isoantigens - physiology Medical sciences Membrane Glycoproteins - physiology Myeloblastin - immunology Myeloblastin - metabolism Neutrophils - enzymology Neutrophils - metabolism Receptors, Cell Surface - physiology Transfection
Online-Zugang:	Volltext
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