Inflammatory Markers and Progression of Subclinical Atherosclerosis in Healthy Postmenopausal Women (from the Estrogen in the Prevention of Atherosclerosis Trial)
The objective of this study was to determine whether high-sensitivity C-reactive protein (hs-CRP) and serum soluble intercellular adhesion molecule-1 (sICAM-1) correlate with progression of subclinical atherosclerosis. Secondarily, the long-term effect of oral estradiol on hs-CRP and sICAM-1 were de...
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| Veröffentlicht in: | The American journal of cardiology 2008-04, Vol.101 (8), p.1131-1133 |
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| container_title | The American journal of cardiology |
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| creator | Hodis, Howard N., MD St. John, Jan A., MPH Xiang, Min, MS Cushman, Mary, MD, MSc Lobo, Roger A., MD Mack, Wendy J., PhD |
| description | The objective of this study was to determine whether high-sensitivity C-reactive protein (hs-CRP) and serum soluble intercellular adhesion molecule-1 (sICAM-1) correlate with progression of subclinical atherosclerosis. Secondarily, the long-term effect of oral estradiol on hs-CRP and sICAM-1 were determined. Data were analyzed from 180 healthy postmenopausal women aged 45 to 80 years randomly assigned to either unopposed micronized 17β-estradiol 1 mg/day or placebo in the Estrogen in the Prevention of Atherosclerosis Trial (EPAT). Carotid artery intima-media thickness (CIMT), hs-CRP, and sICAM-1 were measured at baseline and every 6 months thereafter for 2 years. Unopposed 17β-estradiol significantly increased hs-CRP (p = 0.01) and decreased sICAM-1 compared with placebo (p = 0.04). Changes in hs-CRP and sICAM-1 did not correlate with changes in carotid artery intima-media thickness. In conclusion, although unopposed 17β-estradiol significantly altered hs-CRP and sICAM-1, neither marker was associated with progression of subclinical atherosclerosis. |
| doi_str_mv | 10.1016/j.amjcard.2007.09.120 |
| format | Article |
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Secondarily, the long-term effect of oral estradiol on hs-CRP and sICAM-1 were determined. Data were analyzed from 180 healthy postmenopausal women aged 45 to 80 years randomly assigned to either unopposed micronized 17β-estradiol 1 mg/day or placebo in the Estrogen in the Prevention of Atherosclerosis Trial (EPAT). Carotid artery intima-media thickness (CIMT), hs-CRP, and sICAM-1 were measured at baseline and every 6 months thereafter for 2 years. Unopposed 17β-estradiol significantly increased hs-CRP (p = 0.01) and decreased sICAM-1 compared with placebo (p = 0.04). Changes in hs-CRP and sICAM-1 did not correlate with changes in carotid artery intima-media thickness. In conclusion, although unopposed 17β-estradiol significantly altered hs-CRP and sICAM-1, neither marker was associated with progression of subclinical atherosclerosis.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2007.09.120</identifier><identifier>PMID: 18394446</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - diagnostic imaging ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; C-Reactive Protein - analysis ; C-Reactive Protein - drug effects ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Carotid Arteries - diagnostic imaging ; Cell adhesion & migration ; Correlation analysis ; Disease Progression ; Double-Blind Method ; Estradiol - therapeutic use ; Estrogens ; Estrogens - therapeutic use ; Humans ; Hypolipidemic Agents - therapeutic use ; Intercellular Adhesion Molecule-1 - blood ; Intercellular Adhesion Molecule-1 - drug effects ; Medical sciences ; Middle Aged ; Molecules ; Postmenopause ; Studies ; Tunica Intima - diagnostic imaging ; Tunica Media - diagnostic imaging ; Ultrasonography ; Women</subject><ispartof>The American journal of cardiology, 2008-04, Vol.101 (8), p.1131-1133</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. 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Secondarily, the long-term effect of oral estradiol on hs-CRP and sICAM-1 were determined. Data were analyzed from 180 healthy postmenopausal women aged 45 to 80 years randomly assigned to either unopposed micronized 17β-estradiol 1 mg/day or placebo in the Estrogen in the Prevention of Atherosclerosis Trial (EPAT). Carotid artery intima-media thickness (CIMT), hs-CRP, and sICAM-1 were measured at baseline and every 6 months thereafter for 2 years. Unopposed 17β-estradiol significantly increased hs-CRP (p = 0.01) and decreased sICAM-1 compared with placebo (p = 0.04). Changes in hs-CRP and sICAM-1 did not correlate with changes in carotid artery intima-media thickness. In conclusion, although unopposed 17β-estradiol significantly altered hs-CRP and sICAM-1, neither marker was associated with progression of subclinical atherosclerosis.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Atherosclerosis - diagnostic imaging</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>C-Reactive Protein - analysis</subject><subject>C-Reactive Protein - drug effects</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Cell adhesion & migration</subject><subject>Correlation analysis</subject><subject>Disease Progression</subject><subject>Double-Blind Method</subject><subject>Estradiol - therapeutic use</subject><subject>Estrogens</subject><subject>Estrogens - therapeutic use</subject><subject>Humans</subject><subject>Hypolipidemic Agents - therapeutic use</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Intercellular Adhesion Molecule-1 - drug effects</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecules</subject><subject>Postmenopause</subject><subject>Studies</subject><subject>Tunica Intima - diagnostic imaging</subject><subject>Tunica Media - diagnostic imaging</subject><subject>Ultrasonography</subject><subject>Women</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt1u1DAQhSMEokvhEUAWEggudhn_JF7fgKqq0EpFrNQiLi2vM6HeJvbWTirt6_CkOGwo0t5wY2ui7xzP5ExRvKSwoECrD5uF6TbWxHrBAOQC1IIyeFTM6FKqOVWUPy5mAMDmigp1VDxLaZNLSsvqaXFEl1wJIapZ8evCN63pOtOHuCNfTbzFmIjxNVnF8DNiSi54EhpyNaxt67yzpiUn_Q3GkGw7ni4R58k5mra_2ZFVSH2HPmzNkDL5I-SCvGti6EgWkbPUZ9v8KUvGehXxHn0_vXHoex2dad8_L540pk34YrqPi--fz65Pz-eX375cnJ5czq2QZT_nfGlrqEqslLFQWqtkTUFYELxZc17Xa9GYpQTDlFWQx18qyWulTK0EYyj4cfF277uN4W7A1OvOJYttazyGIWkJosqaEXx9AG7CEH3uTTMOXJaCqQyVe8jmWVLERm-j60zcaQp6TFBv9JSgHhPUoHROMOteTebDusP6n2qKLANvJsCkHEYTjbcuPXAMWCX5nwY-7TnM_-zeYdTJOvQWaxfR9roO7r-tfDxw-LsBt7jD9DA01Ylp0Ffjuo3bBhKYkJzz3y-004U</recordid><startdate>20080415</startdate><enddate>20080415</enddate><creator>Hodis, Howard N., MD</creator><creator>St. John, Jan A., MPH</creator><creator>Xiang, Min, MS</creator><creator>Cushman, Mary, MD, MSc</creator><creator>Lobo, Roger A., MD</creator><creator>Mack, Wendy J., PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080415</creationdate><title>Inflammatory Markers and Progression of Subclinical Atherosclerosis in Healthy Postmenopausal Women (from the Estrogen in the Prevention of Atherosclerosis Trial)</title><author>Hodis, Howard N., MD ; St. John, Jan A., MPH ; Xiang, Min, MS ; Cushman, Mary, MD, MSc ; Lobo, Roger A., MD ; Mack, Wendy J., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-338cd065e69ac05cc97d104c043fb33ddb4fa870a29c909448973d99ad9422e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Atherosclerosis - diagnostic imaging</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>C-Reactive Protein - analysis</topic><topic>C-Reactive Protein - drug effects</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Cell adhesion & migration</topic><topic>Correlation analysis</topic><topic>Disease Progression</topic><topic>Double-Blind Method</topic><topic>Estradiol - therapeutic use</topic><topic>Estrogens</topic><topic>Estrogens - therapeutic use</topic><topic>Humans</topic><topic>Hypolipidemic Agents - therapeutic use</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Intercellular Adhesion Molecule-1 - drug effects</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecules</topic><topic>Postmenopause</topic><topic>Studies</topic><topic>Tunica Intima - diagnostic imaging</topic><topic>Tunica Media - diagnostic imaging</topic><topic>Ultrasonography</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hodis, Howard N., MD</creatorcontrib><creatorcontrib>St. John, Jan A., MPH</creatorcontrib><creatorcontrib>Xiang, Min, MS</creatorcontrib><creatorcontrib>Cushman, Mary, MD, MSc</creatorcontrib><creatorcontrib>Lobo, Roger A., MD</creatorcontrib><creatorcontrib>Mack, Wendy J., PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hodis, Howard N., MD</au><au>St. John, Jan A., MPH</au><au>Xiang, Min, MS</au><au>Cushman, Mary, MD, MSc</au><au>Lobo, Roger A., MD</au><au>Mack, Wendy J., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammatory Markers and Progression of Subclinical Atherosclerosis in Healthy Postmenopausal Women (from the Estrogen in the Prevention of Atherosclerosis Trial)</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2008-04-15</date><risdate>2008</risdate><volume>101</volume><issue>8</issue><spage>1131</spage><epage>1133</epage><pages>1131-1133</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>The objective of this study was to determine whether high-sensitivity C-reactive protein (hs-CRP) and serum soluble intercellular adhesion molecule-1 (sICAM-1) correlate with progression of subclinical atherosclerosis. Secondarily, the long-term effect of oral estradiol on hs-CRP and sICAM-1 were determined. Data were analyzed from 180 healthy postmenopausal women aged 45 to 80 years randomly assigned to either unopposed micronized 17β-estradiol 1 mg/day or placebo in the Estrogen in the Prevention of Atherosclerosis Trial (EPAT). Carotid artery intima-media thickness (CIMT), hs-CRP, and sICAM-1 were measured at baseline and every 6 months thereafter for 2 years. Unopposed 17β-estradiol significantly increased hs-CRP (p = 0.01) and decreased sICAM-1 compared with placebo (p = 0.04). Changes in hs-CRP and sICAM-1 did not correlate with changes in carotid artery intima-media thickness. In conclusion, although unopposed 17β-estradiol significantly altered hs-CRP and sICAM-1, neither marker was associated with progression of subclinical atherosclerosis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18394446</pmid><doi>10.1016/j.amjcard.2007.09.120</doi><tpages>3</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Atherosclerosis (general aspects, experimental research) Atherosclerosis - diagnostic imaging Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels C-Reactive Protein - analysis C-Reactive Protein - drug effects Cardiology. Vascular system Cardiovascular Cardiovascular disease Carotid Arteries - diagnostic imaging Cell adhesion & migration Correlation analysis Disease Progression Double-Blind Method Estradiol - therapeutic use Estrogens Estrogens - therapeutic use Humans Hypolipidemic Agents - therapeutic use Intercellular Adhesion Molecule-1 - blood Intercellular Adhesion Molecule-1 - drug effects Medical sciences Middle Aged Molecules Postmenopause Studies Tunica Intima - diagnostic imaging Tunica Media - diagnostic imaging Ultrasonography Women |
| title | Inflammatory Markers and Progression of Subclinical Atherosclerosis in Healthy Postmenopausal Women (from the Estrogen in the Prevention of Atherosclerosis Trial) |
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