Salivary microbiota of HIV-positive children and its correlation with HIV status, oral diseases, and total secretory IgA
Aim. This study aimed to investigate the prevalence and levels of salivary microorganisms in HIV‐positive children, and their correlation to HIV status, oral lesions, and salivary IgA levels. Design. Forty‐two HIV‐positive and 36 control children were clinically examined, had their saliva collecte...
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| Veröffentlicht in: | International Journal of Paediatric Dentistry 2008-05, Vol.18 (3), p.205-216 |
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| creator | SILVA-BOGHOSSIAN, CARINA CASTRO, GLÓRIA FERNANDA TELES, RICARDO PALMIER DE SOUZA, IVETE P. R. COLOMBO, ANA PAULA V. |
| description | Aim. This study aimed to investigate the prevalence and levels of salivary microorganisms in HIV‐positive children, and their correlation to HIV status, oral lesions, and salivary IgA levels.
Design. Forty‐two HIV‐positive and 36 control children were clinically examined, had their saliva collected and processed for the microbiological analysis of 38 bacterial taxa by the checkerboard method, and salivary IgA quantification by ELISA.
Results. The majority of the species tested were more prevalent in control children than in the HIV group. Mean concentration of total salivary IgA was similar in both groups. High levels of Veillonella parvula were found in children with cheilitis and herpes. Tannerella forsythia, Eikenella Corrodens, and Propionibacterium acnes were prevalent in children with gingivitis, while Fusobacterium periodonticum, Streptococcus gordonii, and Streptococcus oralis were significantly more frequent in children with no oral lesions. Significant negative correlations between salivary IgA levels and Eubacterium nodatum and oral streptococci were observed (P |
| doi_str_mv | 10.1111/j.1365-263X.2007.00864.x |
| format | Article |
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Design. Forty‐two HIV‐positive and 36 control children were clinically examined, had their saliva collected and processed for the microbiological analysis of 38 bacterial taxa by the checkerboard method, and salivary IgA quantification by ELISA.
Results. The majority of the species tested were more prevalent in control children than in the HIV group. Mean concentration of total salivary IgA was similar in both groups. High levels of Veillonella parvula were found in children with cheilitis and herpes. Tannerella forsythia, Eikenella Corrodens, and Propionibacterium acnes were prevalent in children with gingivitis, while Fusobacterium periodonticum, Streptococcus gordonii, and Streptococcus oralis were significantly more frequent in children with no oral lesions. Significant negative correlations between salivary IgA levels and Eubacterium nodatum and oral streptococci were observed (P < 0.05).
Conclusion. HIV‐seropositive children presented significantly lower prevalence and levels of several bacterial species in saliva; HIV‐positive children are able to mount a mucosal immune response; HIV‐seropositive children under highly active antiretroviral therapy presented low prevalence of oral lesions.</description><identifier>ISSN: 0960-7439</identifier><identifier>EISSN: 1365-263X</identifier><identifier>EISSN: 1468-179X</identifier><identifier>DOI: 10.1111/j.1365-263X.2007.00864.x</identifier><identifier>PMID: 18384349</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anti-Retroviral Agents - therapeutic use ; Bacteria - classification ; Bacteria - genetics ; Bacteria - isolation & purification ; Bacteroides forsythus ; Case-Control Studies ; Chi-Square Distribution ; Child, Preschool ; Dentistry ; DNA, Bacterial - analysis ; Eikenella corrodens ; Eubacterium ; Female ; Fusobacterium ; HIV Seropositivity - complications ; HIV Seropositivity - drug therapy ; HIV Seropositivity - immunology ; HIV Seropositivity - microbiology ; Human immunodeficiency virus ; Humans ; Immunoglobulin A - analysis ; Male ; Mouth - immunology ; Mouth - microbiology ; Mouth Diseases - complications ; Mouth Diseases - immunology ; Mouth Diseases - microbiology ; Propionibacterium acnes ; Reference Values ; Saliva - immunology ; Saliva - microbiology ; Statistics, Nonparametric ; Streptococcus gordonii ; Streptococcus oralis ; Veillonella parvula</subject><ispartof>International Journal of Paediatric Dentistry, 2008-05, Vol.18 (3), p.205-216</ispartof><rights>2007 The Authors</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4354-c9628058bf3b85d1dec31750520b866f993d8f246595bfd5c75a235492fdce2c3</citedby><cites>FETCH-LOGICAL-c4354-c9628058bf3b85d1dec31750520b866f993d8f246595bfd5c75a235492fdce2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-263X.2007.00864.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-263X.2007.00864.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18384349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SILVA-BOGHOSSIAN, CARINA</creatorcontrib><creatorcontrib>CASTRO, GLÓRIA FERNANDA</creatorcontrib><creatorcontrib>TELES, RICARDO PALMIER</creatorcontrib><creatorcontrib>DE SOUZA, IVETE P. R.</creatorcontrib><creatorcontrib>COLOMBO, ANA PAULA V.</creatorcontrib><title>Salivary microbiota of HIV-positive children and its correlation with HIV status, oral diseases, and total secretory IgA</title><title>International Journal of Paediatric Dentistry</title><addtitle>Int J Paediatr Dent</addtitle><description>Aim. This study aimed to investigate the prevalence and levels of salivary microorganisms in HIV‐positive children, and their correlation to HIV status, oral lesions, and salivary IgA levels.
Design. Forty‐two HIV‐positive and 36 control children were clinically examined, had their saliva collected and processed for the microbiological analysis of 38 bacterial taxa by the checkerboard method, and salivary IgA quantification by ELISA.
Results. The majority of the species tested were more prevalent in control children than in the HIV group. Mean concentration of total salivary IgA was similar in both groups. High levels of Veillonella parvula were found in children with cheilitis and herpes. Tannerella forsythia, Eikenella Corrodens, and Propionibacterium acnes were prevalent in children with gingivitis, while Fusobacterium periodonticum, Streptococcus gordonii, and Streptococcus oralis were significantly more frequent in children with no oral lesions. Significant negative correlations between salivary IgA levels and Eubacterium nodatum and oral streptococci were observed (P < 0.05).
Conclusion. HIV‐seropositive children presented significantly lower prevalence and levels of several bacterial species in saliva; HIV‐positive children are able to mount a mucosal immune response; HIV‐seropositive children under highly active antiretroviral therapy presented low prevalence of oral lesions.</description><subject>Anti-Retroviral Agents - therapeutic use</subject><subject>Bacteria - classification</subject><subject>Bacteria - genetics</subject><subject>Bacteria - isolation & purification</subject><subject>Bacteroides forsythus</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Child, Preschool</subject><subject>Dentistry</subject><subject>DNA, Bacterial - analysis</subject><subject>Eikenella corrodens</subject><subject>Eubacterium</subject><subject>Female</subject><subject>Fusobacterium</subject><subject>HIV Seropositivity - complications</subject><subject>HIV Seropositivity - drug therapy</subject><subject>HIV Seropositivity - immunology</subject><subject>HIV Seropositivity - microbiology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunoglobulin A - analysis</subject><subject>Male</subject><subject>Mouth - immunology</subject><subject>Mouth - microbiology</subject><subject>Mouth Diseases - complications</subject><subject>Mouth Diseases - immunology</subject><subject>Mouth Diseases - microbiology</subject><subject>Propionibacterium acnes</subject><subject>Reference Values</subject><subject>Saliva - immunology</subject><subject>Saliva - microbiology</subject><subject>Statistics, Nonparametric</subject><subject>Streptococcus gordonii</subject><subject>Streptococcus oralis</subject><subject>Veillonella parvula</subject><issn>0960-7439</issn><issn>1365-263X</issn><issn>1468-179X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtvEzEUhS0EoqHwF5BXrJjBj_FLYlO10EZUBYlSKjaWx-OhDk6c2k6b_ns8JCpL8Ma-8vnOke4BAGLU4nreLVpMOWsIp9ctQUi0CEnetdsnYPb48RTMkOKoER1VB-BFzguEMEMEPQcHWFLZ0U7NwParCf7OpAe49DbF3sdiYBzh2fyqWcfsi79z0N74MCS3gmY1QF8ytDElF0zxcQXvfbmZ5DAXUzb5LYzJBDj47Ex2dZyYUl0DzM4mV2LNmv88egmejSZk92p_H4JvHz9cHp81559P58dH543tKOsaqziRiMl-pL1kAx6cpVgwxAjqJeejUnSQI-k4U6wfB2YFM6SCioyDdcTSQ_Bm57tO8XbjctFLn60Lwaxc3GQtUMelpOSfQqxqFlaiCuVOWPeVc3KjXie_rCvUGOmpHr3QUwt6akFP9eg_9ehtRV_vMzb90g1_wX0fVfB-J7j3wT38t7Gefzmpj4o3O9zn4raPuEm_NBdUMP394lRfnVz--CTQtb6gvwGS8q4u</recordid><startdate>200805</startdate><enddate>200805</enddate><creator>SILVA-BOGHOSSIAN, CARINA</creator><creator>CASTRO, GLÓRIA FERNANDA</creator><creator>TELES, RICARDO PALMIER</creator><creator>DE SOUZA, IVETE P. R.</creator><creator>COLOMBO, ANA PAULA V.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200805</creationdate><title>Salivary microbiota of HIV-positive children and its correlation with HIV status, oral diseases, and total secretory IgA</title><author>SILVA-BOGHOSSIAN, CARINA ; CASTRO, GLÓRIA FERNANDA ; TELES, RICARDO PALMIER ; DE SOUZA, IVETE P. R. ; COLOMBO, ANA PAULA V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4354-c9628058bf3b85d1dec31750520b866f993d8f246595bfd5c75a235492fdce2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anti-Retroviral Agents - therapeutic use</topic><topic>Bacteria - classification</topic><topic>Bacteria - genetics</topic><topic>Bacteria - isolation & purification</topic><topic>Bacteroides forsythus</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Child, Preschool</topic><topic>Dentistry</topic><topic>DNA, Bacterial - analysis</topic><topic>Eikenella corrodens</topic><topic>Eubacterium</topic><topic>Female</topic><topic>Fusobacterium</topic><topic>HIV Seropositivity - complications</topic><topic>HIV Seropositivity - drug therapy</topic><topic>HIV Seropositivity - immunology</topic><topic>HIV Seropositivity - microbiology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunoglobulin A - analysis</topic><topic>Male</topic><topic>Mouth - immunology</topic><topic>Mouth - microbiology</topic><topic>Mouth Diseases - complications</topic><topic>Mouth Diseases - immunology</topic><topic>Mouth Diseases - microbiology</topic><topic>Propionibacterium acnes</topic><topic>Reference Values</topic><topic>Saliva - immunology</topic><topic>Saliva - microbiology</topic><topic>Statistics, Nonparametric</topic><topic>Streptococcus gordonii</topic><topic>Streptococcus oralis</topic><topic>Veillonella parvula</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SILVA-BOGHOSSIAN, CARINA</creatorcontrib><creatorcontrib>CASTRO, GLÓRIA FERNANDA</creatorcontrib><creatorcontrib>TELES, RICARDO PALMIER</creatorcontrib><creatorcontrib>DE SOUZA, IVETE P. 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R.</au><au>COLOMBO, ANA PAULA V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salivary microbiota of HIV-positive children and its correlation with HIV status, oral diseases, and total secretory IgA</atitle><jtitle>International Journal of Paediatric Dentistry</jtitle><addtitle>Int J Paediatr Dent</addtitle><date>2008-05</date><risdate>2008</risdate><volume>18</volume><issue>3</issue><spage>205</spage><epage>216</epage><pages>205-216</pages><issn>0960-7439</issn><eissn>1365-263X</eissn><eissn>1468-179X</eissn><abstract>Aim. This study aimed to investigate the prevalence and levels of salivary microorganisms in HIV‐positive children, and their correlation to HIV status, oral lesions, and salivary IgA levels.
Design. Forty‐two HIV‐positive and 36 control children were clinically examined, had their saliva collected and processed for the microbiological analysis of 38 bacterial taxa by the checkerboard method, and salivary IgA quantification by ELISA.
Results. The majority of the species tested were more prevalent in control children than in the HIV group. Mean concentration of total salivary IgA was similar in both groups. High levels of Veillonella parvula were found in children with cheilitis and herpes. Tannerella forsythia, Eikenella Corrodens, and Propionibacterium acnes were prevalent in children with gingivitis, while Fusobacterium periodonticum, Streptococcus gordonii, and Streptococcus oralis were significantly more frequent in children with no oral lesions. Significant negative correlations between salivary IgA levels and Eubacterium nodatum and oral streptococci were observed (P < 0.05).
Conclusion. HIV‐seropositive children presented significantly lower prevalence and levels of several bacterial species in saliva; HIV‐positive children are able to mount a mucosal immune response; HIV‐seropositive children under highly active antiretroviral therapy presented low prevalence of oral lesions.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18384349</pmid><doi>10.1111/j.1365-263X.2007.00864.x</doi><tpages>12</tpages></addata></record> |
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| ispartof | International Journal of Paediatric Dentistry, 2008-05, Vol.18 (3), p.205-216 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Anti-Retroviral Agents - therapeutic use Bacteria - classification Bacteria - genetics Bacteria - isolation & purification Bacteroides forsythus Case-Control Studies Chi-Square Distribution Child, Preschool Dentistry DNA, Bacterial - analysis Eikenella corrodens Eubacterium Female Fusobacterium HIV Seropositivity - complications HIV Seropositivity - drug therapy HIV Seropositivity - immunology HIV Seropositivity - microbiology Human immunodeficiency virus Humans Immunoglobulin A - analysis Male Mouth - immunology Mouth - microbiology Mouth Diseases - complications Mouth Diseases - immunology Mouth Diseases - microbiology Propionibacterium acnes Reference Values Saliva - immunology Saliva - microbiology Statistics, Nonparametric Streptococcus gordonii Streptococcus oralis Veillonella parvula |
| title | Salivary microbiota of HIV-positive children and its correlation with HIV status, oral diseases, and total secretory IgA |
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