Carnitine Palmitoyltransferase I and Acyl-CoA Dehydrogenase 9 in Retina: Insights of Retinopathy in Mitochondrial Trifunctional Protein Defects

Progressive pigment chorioretinopathy is a major long-term complication of mitochondrial trifunctional protein (MTP) defects, disorders of mitochondrial fatty acid beta-oxidation. To better understand the pathogenesis of the retinopathy component, the authors studied expression of the main regulator...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2008-04, Vol.49 (4), p.1660-1664
Hauptverfasser:	Roomets, Eva, Kivela, Tero, Tyni, Tiina
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-CoA Dehydrogenase, Long-Chain - genetics Acyl-CoA Dehydrogenase, Long-Chain - metabolism Animals Biological and medical sciences Brain - enzymology Carnitine O-Palmitoyltransferase - genetics Carnitine O-Palmitoyltransferase - metabolism Cell Line Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic - physiology Humans Immunoblotting Immunohistochemistry In Situ Hybridization Liver - enzymology Medical sciences Mitochondrial Trifunctional Protein Multienzyme Complexes - metabolism Muscle, Skeletal - enzymology Ophthalmology Pigment Epithelium of Eye - enzymology Rats Rats, Wistar Retina - enzymology Retinal Diseases - enzymology Retinal Ganglion Cells - enzymology Retinopathies Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Vertebrates: nervous system and sense organs
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