Sulfonamidolactam inhibitors of coagulation factor Xa

The synthesis and SAR of N-aryl-3-(arylsulfonylamino)-piperidone inhibitors of Factor Xa is described. Compound 55 is a representative example of this series with fXa K i = 0.043 nM. As part of an effort to identify novel backups for previously reported pyrazole-based coagulation Factor Xa inhibitor...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-04, Vol.18 (7), p.2428-2433
Hauptverfasser:	Smallheer, Joanne M., Wang, Shuaige, Laws, Mia L., Nakajima, Suanne, Hu, Zilun, Han, Wei, Jacobson, Irina, Luettgen, Joseph M., Rossi, Karen A., Rendina, Alan R., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S., Quan, Mimi L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulant Anticoagulants - chemical synthesis Anticoagulants - pharmacology Antithrombotic Binding Sites Biological and medical sciences Blood Coagulation Tests Blood. Blood coagulation. Reticuloendothelial system Factor Xa Inhibitors Lactams - chemical synthesis Lactams - pharmacology Ligands Medical sciences Models, Chemical Pharmacology. Drug treatments Piperidones - chemical synthesis Piperidones - pharmacology Serine protease inhibitors Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - pharmacology
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