Adeno-associated viral gene transfer of transforming growth factor-beta1 to human mesenchymal stem cells improves cartilage repair

Bone marrow cells are routinely accessed clinically for cartilage repair. This study was performed to determine whether adeno-associated virus (AAV) effectively transduces human bone marrow-derived mesenchymal stem cells (hMSC) in vitro, whether AAV infection interferes with hMSC chondrogenesis and...

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Veröffentlicht in:	Gene therapy 2007-05, Vol.14 (10), p.804-813
Hauptverfasser:	Pagnotto, M R, Wang, Z, Karpie, J C, Ferretti, M, Xiao, X, Chu, C R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Cartilage, Articular - injuries Cartilage, Articular - pathology Cells, Cultured Chondrocytes - pathology Chondrogenesis Dependovirus - genetics Gene Expression Genetic Therapy - methods Genetic Vectors - administration & dosage Green Fluorescent Proteins - genetics Humans Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - metabolism Microscopy, Fluorescence Rats Rats, Mutant Strains Transduction, Genetic - methods Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Transgenes
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