Immune responses of pigs to commercialized emulsion FMD vaccines and live virus challenge
Abstract The immune response to structural and non-structural proteins (NSPs) was studied on sequential serum samples in swine from O/Taiwan/97 FMDV challenge studies, outbreaks and after vaccination. The results showed that pigs vaccinated with a commercial vaccine prior to or after infection maint...
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| Veröffentlicht in: | Vaccine 2007-05, Vol.25 (22), p.4464-4469 |
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| container_title | Vaccine |
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| creator | Chen, S.P Lee, M.C Sun, Y.F Cheng, I.C Yang, P.C Lin, Y.L Jong, M.H Robertson, I.D Edwards, J.R Ellis, T.M |
| description | Abstract The immune response to structural and non-structural proteins (NSPs) was studied on sequential serum samples in swine from O/Taiwan/97 FMDV challenge studies, outbreaks and after vaccination. The results showed that pigs vaccinated with a commercial vaccine prior to or after infection maintained high neutralizing antibody titers with gradual decline from peak titers over the duration of this study. However, neutralizing antibody titers in non-vaccinated pigs only reached moderate levels 2–4 weeks post infection and remained low thereafter. For the 3B and 3ABC NSP antibody ELISA responses, there were gradually decreasing levels of NSP antibody over time. In multiple vaccinations, all pigs showed significant increases in neutralizing antibodies after booster vaccination. For the 3B NSP antibody ELISA after vaccination, the mean S/P ratios for pigs vaccinated with all three FMD vaccines were all below the 0.23 cut-off value set by the manufacture, but some sera from individual vaccinated pigs gave results above this cut-off after primary or secondary vaccination. However, with the 3ABC NSP antibody ELISA, all sera from vaccinated pigs had negative results for NSP antibody for all time points. |
| doi_str_mv | 10.1016/j.vaccine.2007.03.019 |
| format | Article |
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The results showed that pigs vaccinated with a commercial vaccine prior to or after infection maintained high neutralizing antibody titers with gradual decline from peak titers over the duration of this study. However, neutralizing antibody titers in non-vaccinated pigs only reached moderate levels 2–4 weeks post infection and remained low thereafter. For the 3B and 3ABC NSP antibody ELISA responses, there were gradually decreasing levels of NSP antibody over time. In multiple vaccinations, all pigs showed significant increases in neutralizing antibodies after booster vaccination. For the 3B NSP antibody ELISA after vaccination, the mean S/P ratios for pigs vaccinated with all three FMD vaccines were all below the 0.23 cut-off value set by the manufacture, but some sera from individual vaccinated pigs gave results above this cut-off after primary or secondary vaccination. However, with the 3ABC NSP antibody ELISA, all sera from vaccinated pigs had negative results for NSP antibody for all time points.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2007.03.019</identifier><identifier>PMID: 17445957</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Allergy and Immunology ; Animals ; Antibodies, Viral - blood ; Antigens ; Applied microbiology ; Biological and medical sciences ; Diagnosis ; Disease Outbreaks - veterinary ; ELISA (enzyme linked immunosorbent assay) ; Emulsions - administration & dosage ; Farms ; Foot & mouth disease ; Foot-and-mouth disease ; Foot-and-Mouth Disease - epidemiology ; Foot-and-Mouth Disease - immunology ; Foot-and-Mouth Disease - prevention & control ; Foot-and-Mouth Disease - virology ; Foot-and-mouth disease virus ; Foot-and-Mouth Disease Virus - immunology ; Foot-and-Mouth Disease Virus - pathogenicity ; Freight forwarding ; Fundamental and applied biological sciences. Psychology ; Hogs ; Immune response ; Infections ; Microbiology ; Miscellaneous ; Neutralization Tests ; Neutralizing antibodies ; Non-structural proteins ; Studies ; Swine ; Swine Diseases - epidemiology ; Swine Diseases - immunology ; Swine Diseases - prevention & control ; Swine Diseases - virology ; Taiwan - epidemiology ; Vaccination - veterinary ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Viral Nonstructural Proteins - immunology ; Viral Structural Proteins - immunology ; Viral Vaccines - administration & dosage ; Viral Vaccines - immunology ; Virology</subject><ispartof>Vaccine, 2007-05, Vol.25 (22), p.4464-4469</ispartof><rights>Elsevier Ltd</rights><rights>2007 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Elsevier Limited May 30, 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-6a267cbd118e268ffeadc8a48bd31aaf657544edce24ab25e4da6e8f7044c3823</citedby><cites>FETCH-LOGICAL-c507t-6a267cbd118e268ffeadc8a48bd31aaf657544edce24ab25e4da6e8f7044c3823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X07003246$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18752388$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17445957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, S.P</creatorcontrib><creatorcontrib>Lee, M.C</creatorcontrib><creatorcontrib>Sun, Y.F</creatorcontrib><creatorcontrib>Cheng, I.C</creatorcontrib><creatorcontrib>Yang, P.C</creatorcontrib><creatorcontrib>Lin, Y.L</creatorcontrib><creatorcontrib>Jong, M.H</creatorcontrib><creatorcontrib>Robertson, I.D</creatorcontrib><creatorcontrib>Edwards, J.R</creatorcontrib><creatorcontrib>Ellis, T.M</creatorcontrib><title>Immune responses of pigs to commercialized emulsion FMD vaccines and live virus challenge</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract The immune response to structural and non-structural proteins (NSPs) was studied on sequential serum samples in swine from O/Taiwan/97 FMDV challenge studies, outbreaks and after vaccination. The results showed that pigs vaccinated with a commercial vaccine prior to or after infection maintained high neutralizing antibody titers with gradual decline from peak titers over the duration of this study. However, neutralizing antibody titers in non-vaccinated pigs only reached moderate levels 2–4 weeks post infection and remained low thereafter. For the 3B and 3ABC NSP antibody ELISA responses, there were gradually decreasing levels of NSP antibody over time. In multiple vaccinations, all pigs showed significant increases in neutralizing antibodies after booster vaccination. For the 3B NSP antibody ELISA after vaccination, the mean S/P ratios for pigs vaccinated with all three FMD vaccines were all below the 0.23 cut-off value set by the manufacture, but some sera from individual vaccinated pigs gave results above this cut-off after primary or secondary vaccination. However, with the 3ABC NSP antibody ELISA, all sera from vaccinated pigs had negative results for NSP antibody for all time points.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Antigens</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Diagnosis</subject><subject>Disease Outbreaks - veterinary</subject><subject>ELISA (enzyme linked immunosorbent assay)</subject><subject>Emulsions - administration & dosage</subject><subject>Farms</subject><subject>Foot & mouth disease</subject><subject>Foot-and-mouth disease</subject><subject>Foot-and-Mouth Disease - epidemiology</subject><subject>Foot-and-Mouth Disease - immunology</subject><subject>Foot-and-Mouth Disease - prevention & control</subject><subject>Foot-and-Mouth Disease - virology</subject><subject>Foot-and-mouth disease virus</subject><subject>Foot-and-Mouth Disease Virus - immunology</subject><subject>Foot-and-Mouth Disease Virus - pathogenicity</subject><subject>Freight forwarding</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hogs</subject><subject>Immune response</subject><subject>Infections</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Neutralization Tests</subject><subject>Neutralizing antibodies</subject><subject>Non-structural proteins</subject><subject>Studies</subject><subject>Swine</subject><subject>Swine Diseases - epidemiology</subject><subject>Swine Diseases - immunology</subject><subject>Swine Diseases - prevention & control</subject><subject>Swine Diseases - virology</subject><subject>Taiwan - epidemiology</subject><subject>Vaccination - veterinary</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Viral Nonstructural Proteins - immunology</subject><subject>Viral Structural Proteins - immunology</subject><subject>Viral Vaccines - administration & dosage</subject><subject>Viral Vaccines - immunology</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk9vEzEQxS0EomngI4AsIbjtMvb6Xy4gVFqoVMQBkOBkOd7Z4rDrDXY2Uvn0OMpKkXrpaS6_eTPz3hDygkHNgKm3m3rvvA8Raw6ga2hqYKtHZMGMbioumXlMFsCVqASDn2fkPOcNAMiGrZ6SM6aFkCupF-TX9TBMEWnCvB1jxkzHjm7Dbaa7kfpxGDD54PrwD1uKw9TnMEZ69eUjnadn6mJL-7BHug9pytT_dn2P8RafkSed6zM-n-uS_Li6_H7xubr5-un64sNN5SXoXaUcV9qvW8YMcmW6Dl3rjRNm3TbMuU5JLYXA1iMXbs0litYpNJ0GIXxjeLMkb4662zT-nTDv7BCyx753Eccp2wIqJZl-EOTA9YoXi5bk1T1wM04pliMsk3IFhgslCiWPlE9jzgk7u01hcOnOMrCHiOzGzibZQ0QWGlsiKn0vZ_VpPWB76pozKcDrGXDZu75LLvqQT5zRkjfGFO79kcPi7j5gstkHjB7bkNDvbDuGB1d5d0_B9yGGMvQP3mE-XW0zt2C_Hf7p8E6gAZpiQvMf7QjG3A</recordid><startdate>20070530</startdate><enddate>20070530</enddate><creator>Chen, S.P</creator><creator>Lee, M.C</creator><creator>Sun, Y.F</creator><creator>Cheng, I.C</creator><creator>Yang, P.C</creator><creator>Lin, Y.L</creator><creator>Jong, M.H</creator><creator>Robertson, I.D</creator><creator>Edwards, J.R</creator><creator>Ellis, T.M</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20070530</creationdate><title>Immune responses of pigs to commercialized emulsion FMD vaccines and live virus challenge</title><author>Chen, S.P ; Lee, M.C ; Sun, Y.F ; Cheng, I.C ; Yang, P.C ; Lin, Y.L ; Jong, M.H ; Robertson, I.D ; Edwards, J.R ; Ellis, T.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-6a267cbd118e268ffeadc8a48bd31aaf657544edce24ab25e4da6e8f7044c3823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>Antigens</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Diagnosis</topic><topic>Disease Outbreaks - veterinary</topic><topic>ELISA (enzyme linked immunosorbent assay)</topic><topic>Emulsions - administration & dosage</topic><topic>Farms</topic><topic>Foot & mouth disease</topic><topic>Foot-and-mouth disease</topic><topic>Foot-and-Mouth Disease - epidemiology</topic><topic>Foot-and-Mouth Disease - immunology</topic><topic>Foot-and-Mouth Disease - prevention & control</topic><topic>Foot-and-Mouth Disease - virology</topic><topic>Foot-and-mouth disease virus</topic><topic>Foot-and-Mouth Disease Virus - immunology</topic><topic>Foot-and-Mouth Disease Virus - pathogenicity</topic><topic>Freight forwarding</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hogs</topic><topic>Immune response</topic><topic>Infections</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Neutralization Tests</topic><topic>Neutralizing antibodies</topic><topic>Non-structural proteins</topic><topic>Studies</topic><topic>Swine</topic><topic>Swine Diseases - epidemiology</topic><topic>Swine Diseases - immunology</topic><topic>Swine Diseases - prevention & control</topic><topic>Swine Diseases - virology</topic><topic>Taiwan - epidemiology</topic><topic>Vaccination - veterinary</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Viral Nonstructural Proteins - immunology</topic><topic>Viral Structural Proteins - immunology</topic><topic>Viral Vaccines - administration & dosage</topic><topic>Viral Vaccines - immunology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, S.P</creatorcontrib><creatorcontrib>Lee, M.C</creatorcontrib><creatorcontrib>Sun, Y.F</creatorcontrib><creatorcontrib>Cheng, I.C</creatorcontrib><creatorcontrib>Yang, P.C</creatorcontrib><creatorcontrib>Lin, Y.L</creatorcontrib><creatorcontrib>Jong, M.H</creatorcontrib><creatorcontrib>Robertson, I.D</creatorcontrib><creatorcontrib>Edwards, J.R</creatorcontrib><creatorcontrib>Ellis, T.M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, S.P</au><au>Lee, M.C</au><au>Sun, Y.F</au><au>Cheng, I.C</au><au>Yang, P.C</au><au>Lin, Y.L</au><au>Jong, M.H</au><au>Robertson, I.D</au><au>Edwards, J.R</au><au>Ellis, T.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune responses of pigs to commercialized emulsion FMD vaccines and live virus challenge</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2007-05-30</date><risdate>2007</risdate><volume>25</volume><issue>22</issue><spage>4464</spage><epage>4469</epage><pages>4464-4469</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Abstract The immune response to structural and non-structural proteins (NSPs) was studied on sequential serum samples in swine from O/Taiwan/97 FMDV challenge studies, outbreaks and after vaccination. The results showed that pigs vaccinated with a commercial vaccine prior to or after infection maintained high neutralizing antibody titers with gradual decline from peak titers over the duration of this study. However, neutralizing antibody titers in non-vaccinated pigs only reached moderate levels 2–4 weeks post infection and remained low thereafter. For the 3B and 3ABC NSP antibody ELISA responses, there were gradually decreasing levels of NSP antibody over time. In multiple vaccinations, all pigs showed significant increases in neutralizing antibodies after booster vaccination. For the 3B NSP antibody ELISA after vaccination, the mean S/P ratios for pigs vaccinated with all three FMD vaccines were all below the 0.23 cut-off value set by the manufacture, but some sera from individual vaccinated pigs gave results above this cut-off after primary or secondary vaccination. However, with the 3ABC NSP antibody ELISA, all sera from vaccinated pigs had negative results for NSP antibody for all time points.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17445957</pmid><doi>10.1016/j.vaccine.2007.03.019</doi><tpages>6</tpages></addata></record> |
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| subjects | Allergy and Immunology Animals Antibodies, Viral - blood Antigens Applied microbiology Biological and medical sciences Diagnosis Disease Outbreaks - veterinary ELISA (enzyme linked immunosorbent assay) Emulsions - administration & dosage Farms Foot & mouth disease Foot-and-mouth disease Foot-and-Mouth Disease - epidemiology Foot-and-Mouth Disease - immunology Foot-and-Mouth Disease - prevention & control Foot-and-Mouth Disease - virology Foot-and-mouth disease virus Foot-and-Mouth Disease Virus - immunology Foot-and-Mouth Disease Virus - pathogenicity Freight forwarding Fundamental and applied biological sciences. Psychology Hogs Immune response Infections Microbiology Miscellaneous Neutralization Tests Neutralizing antibodies Non-structural proteins Studies Swine Swine Diseases - epidemiology Swine Diseases - immunology Swine Diseases - prevention & control Swine Diseases - virology Taiwan - epidemiology Vaccination - veterinary Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral Nonstructural Proteins - immunology Viral Structural Proteins - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology Virology |
| title | Immune responses of pigs to commercialized emulsion FMD vaccines and live virus challenge |
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