Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels
In this review, we examine what is known about the mechanism of action of the auxiliary alpha2delta subunits of voltage-gated Ca(2+) (Ca(v)) channels. First, to provide some background on the alpha2delta proteins, we discuss the genes encoding these channels, in addition to the topology and predicte...
Gespeichert in:
| Veröffentlicht in: | Trends in pharmacological sciences (Regular ed.) 2007-05, Vol.28 (5), p.220-228 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 228 |
|---|---|
| container_issue | 5 |
| container_start_page | 220 |
| container_title | Trends in pharmacological sciences (Regular ed.) |
| container_volume | 28 |
| creator | Davies, Anthony Hendrich, Jan Van Minh, Alexandra Tran Wratten, Jack Douglas, Leon Dolphin, Annette C |
| description | In this review, we examine what is known about the mechanism of action of the auxiliary alpha2delta subunits of voltage-gated Ca(2+) (Ca(v)) channels. First, to provide some background on the alpha2delta proteins, we discuss the genes encoding these channels, in addition to the topology and predicted structure of the alpha2delta subunits. We then describe the effects of alpha2delta subunits on the biophysical properties of Ca(v) channels and their physiological function. All alpha2delta subunits increase the density at the plasma membrane of Ca(2+) channels activated by high voltage, and we discuss what is known about the mechanism underlying this trafficking. Finally, we consider the link between alpha2delta subunits and disease, both in terms of spontaneous and engineered mouse mutants that show cerebellar ataxia and spike-wave epilepsy, and in terms of neuropathic pain and the mechanism of action of the gabapentinoid drugs - small-molecule ligands of the alpha2delta-1 and alpha2delta-2 subunits. |
| doi_str_mv | 10.1016/j.tips.2007.03.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_70465888</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70465888</sourcerecordid><originalsourceid>FETCH-LOGICAL-p139t-1f22111322c4484ed2a033d909f5b66368290a7573fdcdb89fa83163ebfc5dcf3</originalsourceid><addsrcrecordid>eNo1kEtLAzEAhHNQbK3-AQ-Sk-hh17x39yilVaEgiJ6XbB5tSnazNonQf--K9TQw8zEMA8ANRiVGWDzuy-TGWBKEqhLREiF-BuZTwAuBWTUDlzHuEUKUEnwBZrhiiHJG5-B9nQeVXBikh50LPmyPMFiYdgZKP-7kPXnQxicJY-7y4FL8Tb_D5GxNsZXJaKikVy73UO3kMBgfr8C5lT6a65MuwOd69bF8KTZvz6_Lp00xYtqkAltCMMaUEMVYzYwmcpqnG9RY3glBRU0aJCteUauV7urGyppiQU1nFdfK0gW4--sdD-Erm5ja3kVlvJeDCTm2FWKC13U9gbcnMHe90e14cL08HNv_F-gPx_9eAw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70465888</pqid></control><display><type>article</type><title>Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Davies, Anthony ; Hendrich, Jan ; Van Minh, Alexandra Tran ; Wratten, Jack ; Douglas, Leon ; Dolphin, Annette C</creator><creatorcontrib>Davies, Anthony ; Hendrich, Jan ; Van Minh, Alexandra Tran ; Wratten, Jack ; Douglas, Leon ; Dolphin, Annette C</creatorcontrib><description>In this review, we examine what is known about the mechanism of action of the auxiliary alpha2delta subunits of voltage-gated Ca(2+) (Ca(v)) channels. First, to provide some background on the alpha2delta proteins, we discuss the genes encoding these channels, in addition to the topology and predicted structure of the alpha2delta subunits. We then describe the effects of alpha2delta subunits on the biophysical properties of Ca(v) channels and their physiological function. All alpha2delta subunits increase the density at the plasma membrane of Ca(2+) channels activated by high voltage, and we discuss what is known about the mechanism underlying this trafficking. Finally, we consider the link between alpha2delta subunits and disease, both in terms of spontaneous and engineered mouse mutants that show cerebellar ataxia and spike-wave epilepsy, and in terms of neuropathic pain and the mechanism of action of the gabapentinoid drugs - small-molecule ligands of the alpha2delta-1 and alpha2delta-2 subunits.</description><identifier>ISSN: 0165-6147</identifier><identifier>DOI: 10.1016/j.tips.2007.03.005</identifier><identifier>PMID: 17403543</identifier><language>eng</language><publisher>England</publisher><subject>Amines - pharmacology ; Animals ; Calcium Channel Blockers - pharmacology ; Calcium Channels - genetics ; Calcium Channels - physiology ; Calcium Channels - ultrastructure ; Cell Membrane - metabolism ; Cerebellar Ataxia - physiopathology ; Cyclohexanecarboxylic Acids - pharmacology ; Epilepsy - physiopathology ; Gabapentin ; gamma-Aminobutyric Acid - pharmacology ; Humans ; Ion Channel Gating ; Mice ; Neuralgia - physiopathology ; Protein Subunits - physiology</subject><ispartof>Trends in pharmacological sciences (Regular ed.), 2007-05, Vol.28 (5), p.220-228</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17403543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davies, Anthony</creatorcontrib><creatorcontrib>Hendrich, Jan</creatorcontrib><creatorcontrib>Van Minh, Alexandra Tran</creatorcontrib><creatorcontrib>Wratten, Jack</creatorcontrib><creatorcontrib>Douglas, Leon</creatorcontrib><creatorcontrib>Dolphin, Annette C</creatorcontrib><title>Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels</title><title>Trends in pharmacological sciences (Regular ed.)</title><addtitle>Trends Pharmacol Sci</addtitle><description>In this review, we examine what is known about the mechanism of action of the auxiliary alpha2delta subunits of voltage-gated Ca(2+) (Ca(v)) channels. First, to provide some background on the alpha2delta proteins, we discuss the genes encoding these channels, in addition to the topology and predicted structure of the alpha2delta subunits. We then describe the effects of alpha2delta subunits on the biophysical properties of Ca(v) channels and their physiological function. All alpha2delta subunits increase the density at the plasma membrane of Ca(2+) channels activated by high voltage, and we discuss what is known about the mechanism underlying this trafficking. Finally, we consider the link between alpha2delta subunits and disease, both in terms of spontaneous and engineered mouse mutants that show cerebellar ataxia and spike-wave epilepsy, and in terms of neuropathic pain and the mechanism of action of the gabapentinoid drugs - small-molecule ligands of the alpha2delta-1 and alpha2delta-2 subunits.</description><subject>Amines - pharmacology</subject><subject>Animals</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Calcium Channels - genetics</subject><subject>Calcium Channels - physiology</subject><subject>Calcium Channels - ultrastructure</subject><subject>Cell Membrane - metabolism</subject><subject>Cerebellar Ataxia - physiopathology</subject><subject>Cyclohexanecarboxylic Acids - pharmacology</subject><subject>Epilepsy - physiopathology</subject><subject>Gabapentin</subject><subject>gamma-Aminobutyric Acid - pharmacology</subject><subject>Humans</subject><subject>Ion Channel Gating</subject><subject>Mice</subject><subject>Neuralgia - physiopathology</subject><subject>Protein Subunits - physiology</subject><issn>0165-6147</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtLAzEAhHNQbK3-AQ-Sk-hh17x39yilVaEgiJ6XbB5tSnazNonQf--K9TQw8zEMA8ANRiVGWDzuy-TGWBKEqhLREiF-BuZTwAuBWTUDlzHuEUKUEnwBZrhiiHJG5-B9nQeVXBikh50LPmyPMFiYdgZKP-7kPXnQxicJY-7y4FL8Tb_D5GxNsZXJaKikVy73UO3kMBgfr8C5lT6a65MuwOd69bF8KTZvz6_Lp00xYtqkAltCMMaUEMVYzYwmcpqnG9RY3glBRU0aJCteUauV7urGyppiQU1nFdfK0gW4--sdD-Erm5ja3kVlvJeDCTm2FWKC13U9gbcnMHe90e14cL08HNv_F-gPx_9eAw</recordid><startdate>200705</startdate><enddate>200705</enddate><creator>Davies, Anthony</creator><creator>Hendrich, Jan</creator><creator>Van Minh, Alexandra Tran</creator><creator>Wratten, Jack</creator><creator>Douglas, Leon</creator><creator>Dolphin, Annette C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200705</creationdate><title>Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels</title><author>Davies, Anthony ; Hendrich, Jan ; Van Minh, Alexandra Tran ; Wratten, Jack ; Douglas, Leon ; Dolphin, Annette C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-1f22111322c4484ed2a033d909f5b66368290a7573fdcdb89fa83163ebfc5dcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Amines - pharmacology</topic><topic>Animals</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Calcium Channels - genetics</topic><topic>Calcium Channels - physiology</topic><topic>Calcium Channels - ultrastructure</topic><topic>Cell Membrane - metabolism</topic><topic>Cerebellar Ataxia - physiopathology</topic><topic>Cyclohexanecarboxylic Acids - pharmacology</topic><topic>Epilepsy - physiopathology</topic><topic>Gabapentin</topic><topic>gamma-Aminobutyric Acid - pharmacology</topic><topic>Humans</topic><topic>Ion Channel Gating</topic><topic>Mice</topic><topic>Neuralgia - physiopathology</topic><topic>Protein Subunits - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davies, Anthony</creatorcontrib><creatorcontrib>Hendrich, Jan</creatorcontrib><creatorcontrib>Van Minh, Alexandra Tran</creatorcontrib><creatorcontrib>Wratten, Jack</creatorcontrib><creatorcontrib>Douglas, Leon</creatorcontrib><creatorcontrib>Dolphin, Annette C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in pharmacological sciences (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davies, Anthony</au><au>Hendrich, Jan</au><au>Van Minh, Alexandra Tran</au><au>Wratten, Jack</au><au>Douglas, Leon</au><au>Dolphin, Annette C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels</atitle><jtitle>Trends in pharmacological sciences (Regular ed.)</jtitle><addtitle>Trends Pharmacol Sci</addtitle><date>2007-05</date><risdate>2007</risdate><volume>28</volume><issue>5</issue><spage>220</spage><epage>228</epage><pages>220-228</pages><issn>0165-6147</issn><abstract>In this review, we examine what is known about the mechanism of action of the auxiliary alpha2delta subunits of voltage-gated Ca(2+) (Ca(v)) channels. First, to provide some background on the alpha2delta proteins, we discuss the genes encoding these channels, in addition to the topology and predicted structure of the alpha2delta subunits. We then describe the effects of alpha2delta subunits on the biophysical properties of Ca(v) channels and their physiological function. All alpha2delta subunits increase the density at the plasma membrane of Ca(2+) channels activated by high voltage, and we discuss what is known about the mechanism underlying this trafficking. Finally, we consider the link between alpha2delta subunits and disease, both in terms of spontaneous and engineered mouse mutants that show cerebellar ataxia and spike-wave epilepsy, and in terms of neuropathic pain and the mechanism of action of the gabapentinoid drugs - small-molecule ligands of the alpha2delta-1 and alpha2delta-2 subunits.</abstract><cop>England</cop><pmid>17403543</pmid><doi>10.1016/j.tips.2007.03.005</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-6147 |
| ispartof | Trends in pharmacological sciences (Regular ed.), 2007-05, Vol.28 (5), p.220-228 |
| issn | 0165-6147 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70465888 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amines - pharmacology Animals Calcium Channel Blockers - pharmacology Calcium Channels - genetics Calcium Channels - physiology Calcium Channels - ultrastructure Cell Membrane - metabolism Cerebellar Ataxia - physiopathology Cyclohexanecarboxylic Acids - pharmacology Epilepsy - physiopathology Gabapentin gamma-Aminobutyric Acid - pharmacology Humans Ion Channel Gating Mice Neuralgia - physiopathology Protein Subunits - physiology |
| title | Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T01%3A28%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functional%20biology%20of%20the%20alpha(2)delta%20subunits%20of%20voltage-gated%20calcium%20channels&rft.jtitle=Trends%20in%20pharmacological%20sciences%20(Regular%20ed.)&rft.au=Davies,%20Anthony&rft.date=2007-05&rft.volume=28&rft.issue=5&rft.spage=220&rft.epage=228&rft.pages=220-228&rft.issn=0165-6147&rft_id=info:doi/10.1016/j.tips.2007.03.005&rft_dat=%3Cproquest_pubme%3E70465888%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70465888&rft_id=info:pmid/17403543&rfr_iscdi=true |