Cross-linking a mAb to NKR-P2/NKG2D on dendritic cells induces their activation and maturation leading to enhanced anti-tumor immune response

NKR-P2/NKG2D is the chief tumor recognition receptor of NK cells and some T cells, which recognizes stress inducible ligands on tumors and mediates cell activation. We have recently reported the involvement of NKR-P2 in rat dendritic cell (DC) activation. We demonstrate the potential of agonistic an...

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Veröffentlicht in:	International immunology 2007-05, Vol.19 (5), p.591-607
Hauptverfasser:	Srivastava, Raghvendra M., Varalakshmi, Ch, Khar, Ashok
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antigens, Surface - immunology Antineoplastic Agents - immunology apoptosis B7-2 Antigen - analysis B7-2 Antigen - immunology Cytotoxicity, Immunologic - drug effects dendritic cells Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - immunology Female Flow Cytometry Immunologic Factors - immunology Interleukin-12 - analysis Interleukin-12 - immunology Intracellular Signaling Peptides and Proteins - immunology Lectins, C-Type - immunology Liver Neoplasms, Experimental - immunology Lymphocyte Activation - immunology Male MAP Kinase Signaling System - immunology maturation Neoplasm Transplantation - immunology NF-kappa B - immunology nitric oxide Nitric Oxide - immunology NK Cell Lectin-Like Receptor Subfamily K NKR-P2/NKG2D Rats Rats, Wistar Receptors, Immunologic - immunology Tumor Cells, Cultured Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - immunology
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