Changes in biochemical markers and prediction of effectiveness of intra-articular hyaluronan in patients with knee osteoarthritis
Summary Objective Intra-articular injection of hyaluronan (HA) is frequently used to treat knee osteoarthritis (OA). We studied whether HA injections induced significant changes in levels of biochemical markers in synovial fluid (SF). In addition, we investigated the possibility of predicting the ef...
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| creator | Hasegawa, M., M.D., Ph.D Nakoshi, Y., M.D Tsujii, M., M.D., Ph.D Sudo, A., M.D., Ph.D Masuda, H., M.S Yoshida, T., M.D. Ph.D Uchida, A., M.D., Ph.D |
| description | Summary Objective Intra-articular injection of hyaluronan (HA) is frequently used to treat knee osteoarthritis (OA). We studied whether HA injections induced significant changes in levels of biochemical markers in synovial fluid (SF). In addition, we investigated the possibility of predicting the effectiveness of HA based on these biochemical markers. Methods Twenty-eight patients with knee OA underwent five weekly intra-articular injections of HA. Knee pain was measured on visual analog scale (VAS) before and after the five injections. Levels of biochemical markers, including chondroitin 6-sulfate (C6S), chondroitin 4-sulfate (C4S), keratan sulfate (KS), and tenascin-C (TN-C), were determined before and after the five injections. Correlations between the biochemical markers before HA injection and the improvement of VAS after the five injections were evaluated. Results After HA injections, levels of C6S, C4S, and KS decreased significantly. Inverse correlations were observed between the levels of TN-C and C4S before HA injection and improvement of VAS after the five injections. In contrast, no significant correlation was seen between levels of C6S and KS before injections and improvement of VAS after the five injections. Conclusion The reduction in C6S, C4S, and KS levels after HA injections reflects that HA could help maintain normal cartilage metabolism. Our findings suggest that HA injections are effective in patients whose knees contain low levels of TN-C and C4S, reflecting an early stage of OA and limited synovitis. |
| doi_str_mv | 10.1016/j.joca.2007.09.014 |
| format | Article |
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We studied whether HA injections induced significant changes in levels of biochemical markers in synovial fluid (SF). In addition, we investigated the possibility of predicting the effectiveness of HA based on these biochemical markers. Methods Twenty-eight patients with knee OA underwent five weekly intra-articular injections of HA. Knee pain was measured on visual analog scale (VAS) before and after the five injections. Levels of biochemical markers, including chondroitin 6-sulfate (C6S), chondroitin 4-sulfate (C4S), keratan sulfate (KS), and tenascin-C (TN-C), were determined before and after the five injections. Correlations between the biochemical markers before HA injection and the improvement of VAS after the five injections were evaluated. Results After HA injections, levels of C6S, C4S, and KS decreased significantly. Inverse correlations were observed between the levels of TN-C and C4S before HA injection and improvement of VAS after the five injections. In contrast, no significant correlation was seen between levels of C6S and KS before injections and improvement of VAS after the five injections. Conclusion The reduction in C6S, C4S, and KS levels after HA injections reflects that HA could help maintain normal cartilage metabolism. Our findings suggest that HA injections are effective in patients whose knees contain low levels of TN-C and C4S, reflecting an early stage of OA and limited synovitis.</description><identifier>ISSN: 1063-4584</identifier><identifier>EISSN: 1522-9653</identifier><identifier>DOI: 10.1016/j.joca.2007.09.014</identifier><identifier>PMID: 17951079</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; Aged, 80 and over ; Biomarker ; Biomarkers ; Chromatography, High Pressure Liquid ; Female ; Glycosaminoglycans - metabolism ; Humans ; Hyaluronan ; Hyaluronic Acid - therapeutic use ; Injections, Intra-Articular ; Knee osteoarthritis ; Male ; Osteoarthritis, Knee - drug therapy ; Osteoarthritis, Knee - physiopathology ; Pain - drug therapy ; Pain Measurement ; Predictive Value of Tests ; Rheumatology ; Synovial fluid ; Synovial Fluid - metabolism ; Tenascin - metabolism</subject><ispartof>Osteoarthritis and cartilage, 2008-04, Vol.16 (4), p.526-529</ispartof><rights>Osteoarthritis Research Society International</rights><rights>2007 Osteoarthritis Research Society International</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-c399ace83c03dc37d1efb2b5ba5cd69766284dd6d840d8e1c868b9035e55dbfd3</citedby><cites>FETCH-LOGICAL-c453t-c399ace83c03dc37d1efb2b5ba5cd69766284dd6d840d8e1c868b9035e55dbfd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1063458407003135$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17951079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasegawa, M., M.D., Ph.D</creatorcontrib><creatorcontrib>Nakoshi, Y., M.D</creatorcontrib><creatorcontrib>Tsujii, M., M.D., Ph.D</creatorcontrib><creatorcontrib>Sudo, A., M.D., Ph.D</creatorcontrib><creatorcontrib>Masuda, H., M.S</creatorcontrib><creatorcontrib>Yoshida, T., M.D. Ph.D</creatorcontrib><creatorcontrib>Uchida, A., M.D., Ph.D</creatorcontrib><title>Changes in biochemical markers and prediction of effectiveness of intra-articular hyaluronan in patients with knee osteoarthritis</title><title>Osteoarthritis and cartilage</title><addtitle>Osteoarthritis Cartilage</addtitle><description>Summary Objective Intra-articular injection of hyaluronan (HA) is frequently used to treat knee osteoarthritis (OA). We studied whether HA injections induced significant changes in levels of biochemical markers in synovial fluid (SF). In addition, we investigated the possibility of predicting the effectiveness of HA based on these biochemical markers. Methods Twenty-eight patients with knee OA underwent five weekly intra-articular injections of HA. Knee pain was measured on visual analog scale (VAS) before and after the five injections. Levels of biochemical markers, including chondroitin 6-sulfate (C6S), chondroitin 4-sulfate (C4S), keratan sulfate (KS), and tenascin-C (TN-C), were determined before and after the five injections. Correlations between the biochemical markers before HA injection and the improvement of VAS after the five injections were evaluated. Results After HA injections, levels of C6S, C4S, and KS decreased significantly. Inverse correlations were observed between the levels of TN-C and C4S before HA injection and improvement of VAS after the five injections. In contrast, no significant correlation was seen between levels of C6S and KS before injections and improvement of VAS after the five injections. Conclusion The reduction in C6S, C4S, and KS levels after HA injections reflects that HA could help maintain normal cartilage metabolism. Our findings suggest that HA injections are effective in patients whose knees contain low levels of TN-C and C4S, reflecting an early stage of OA and limited synovitis.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarker</subject><subject>Biomarkers</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Female</subject><subject>Glycosaminoglycans - metabolism</subject><subject>Humans</subject><subject>Hyaluronan</subject><subject>Hyaluronic Acid - therapeutic use</subject><subject>Injections, Intra-Articular</subject><subject>Knee osteoarthritis</subject><subject>Male</subject><subject>Osteoarthritis, Knee - drug therapy</subject><subject>Osteoarthritis, Knee - physiopathology</subject><subject>Pain - drug therapy</subject><subject>Pain Measurement</subject><subject>Predictive Value of Tests</subject><subject>Rheumatology</subject><subject>Synovial fluid</subject><subject>Synovial Fluid - metabolism</subject><subject>Tenascin - metabolism</subject><issn>1063-4584</issn><issn>1522-9653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGL1TAUhYsozjj6B1xIVu5ab5ombUEEeagzMOBCXYc0ubXp60ueSTrDW_rPTXkPBBeubm4458D9TlG8plBRoOLdXM1eq6oGaCvoK6DNk-Ka8roue8HZ0_wGwcqGd81V8SLGGQAYpfC8uKJtzym0_XXxezcp9xMjsY4M1usJD1arhRxU2GOIRDlDjgGN1cl6R_xIcBwxLw_oMMbtw7oUVKlCsnpdVCDTSS1r8E65LfSokkWXInm0aSJ7h0h8TOizfgo22fiyeDaqJeKry7wpfnz-9H13W95__XK3-3hf6oazVGrW90pjxzQwo1lrKI5DPfBBcW1E3wpRd40xwnQNmA6p7kQ39MA4cm6G0bCb4u059xj8rxVjkgcbNS6LcujXKFtoRMMakYX1WaiDjzHgKI_BZh4nSUFu4OUsN_ByAy-hlxl8Nr25pK_DAc1fy4V0Frw_CzDf-GAxyKgzGJ3RhsxTGm__n__hH7terNuq2uMJ4-zX4DI9SWWsJchvW_Vb89BupTPO_gCfE60W</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Hasegawa, M., M.D., Ph.D</creator><creator>Nakoshi, Y., M.D</creator><creator>Tsujii, M., M.D., Ph.D</creator><creator>Sudo, A., M.D., Ph.D</creator><creator>Masuda, H., M.S</creator><creator>Yoshida, T., M.D. Ph.D</creator><creator>Uchida, A., M.D., Ph.D</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Changes in biochemical markers and prediction of effectiveness of intra-articular hyaluronan in patients with knee osteoarthritis</title><author>Hasegawa, M., M.D., Ph.D ; Nakoshi, Y., M.D ; Tsujii, M., M.D., Ph.D ; Sudo, A., M.D., Ph.D ; Masuda, H., M.S ; Yoshida, T., M.D. Ph.D ; Uchida, A., M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-c399ace83c03dc37d1efb2b5ba5cd69766284dd6d840d8e1c868b9035e55dbfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarker</topic><topic>Biomarkers</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Female</topic><topic>Glycosaminoglycans - metabolism</topic><topic>Humans</topic><topic>Hyaluronan</topic><topic>Hyaluronic Acid - therapeutic use</topic><topic>Injections, Intra-Articular</topic><topic>Knee osteoarthritis</topic><topic>Male</topic><topic>Osteoarthritis, Knee - drug therapy</topic><topic>Osteoarthritis, Knee - physiopathology</topic><topic>Pain - drug therapy</topic><topic>Pain Measurement</topic><topic>Predictive Value of Tests</topic><topic>Rheumatology</topic><topic>Synovial fluid</topic><topic>Synovial Fluid - metabolism</topic><topic>Tenascin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasegawa, M., M.D., Ph.D</creatorcontrib><creatorcontrib>Nakoshi, Y., M.D</creatorcontrib><creatorcontrib>Tsujii, M., M.D., Ph.D</creatorcontrib><creatorcontrib>Sudo, A., M.D., Ph.D</creatorcontrib><creatorcontrib>Masuda, H., M.S</creatorcontrib><creatorcontrib>Yoshida, T., M.D. Ph.D</creatorcontrib><creatorcontrib>Uchida, A., M.D., Ph.D</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoarthritis and cartilage</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasegawa, M., M.D., Ph.D</au><au>Nakoshi, Y., M.D</au><au>Tsujii, M., M.D., Ph.D</au><au>Sudo, A., M.D., Ph.D</au><au>Masuda, H., M.S</au><au>Yoshida, T., M.D. Ph.D</au><au>Uchida, A., M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in biochemical markers and prediction of effectiveness of intra-articular hyaluronan in patients with knee osteoarthritis</atitle><jtitle>Osteoarthritis and cartilage</jtitle><addtitle>Osteoarthritis Cartilage</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>16</volume><issue>4</issue><spage>526</spage><epage>529</epage><pages>526-529</pages><issn>1063-4584</issn><eissn>1522-9653</eissn><abstract>Summary Objective Intra-articular injection of hyaluronan (HA) is frequently used to treat knee osteoarthritis (OA). We studied whether HA injections induced significant changes in levels of biochemical markers in synovial fluid (SF). In addition, we investigated the possibility of predicting the effectiveness of HA based on these biochemical markers. Methods Twenty-eight patients with knee OA underwent five weekly intra-articular injections of HA. Knee pain was measured on visual analog scale (VAS) before and after the five injections. Levels of biochemical markers, including chondroitin 6-sulfate (C6S), chondroitin 4-sulfate (C4S), keratan sulfate (KS), and tenascin-C (TN-C), were determined before and after the five injections. Correlations between the biochemical markers before HA injection and the improvement of VAS after the five injections were evaluated. Results After HA injections, levels of C6S, C4S, and KS decreased significantly. Inverse correlations were observed between the levels of TN-C and C4S before HA injection and improvement of VAS after the five injections. In contrast, no significant correlation was seen between levels of C6S and KS before injections and improvement of VAS after the five injections. Conclusion The reduction in C6S, C4S, and KS levels after HA injections reflects that HA could help maintain normal cartilage metabolism. Our findings suggest that HA injections are effective in patients whose knees contain low levels of TN-C and C4S, reflecting an early stage of OA and limited synovitis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17951079</pmid><doi>10.1016/j.joca.2007.09.014</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Biomarker Biomarkers Chromatography, High Pressure Liquid Female Glycosaminoglycans - metabolism Humans Hyaluronan Hyaluronic Acid - therapeutic use Injections, Intra-Articular Knee osteoarthritis Male Osteoarthritis, Knee - drug therapy Osteoarthritis, Knee - physiopathology Pain - drug therapy Pain Measurement Predictive Value of Tests Rheumatology Synovial fluid Synovial Fluid - metabolism Tenascin - metabolism |
| title | Changes in biochemical markers and prediction of effectiveness of intra-articular hyaluronan in patients with knee osteoarthritis |
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