Reduced self-motion perception in patients with midline cerebellar lesions
Vestibular input to the cerebellum mediates balance and eye movement control. Recent functional MRI studies, however, show midline cerebellar activation during visually induced illusions of self-rotation, thus suggesting that the cerebellum may also contribute to self-motion perception. Here, we inv...
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| Veröffentlicht in: | Neuroreport 2008-04, Vol.19 (6), p.691-693 |
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| creator | Bronstein, Adolfo M Grunfeld, Elizabeth A Faldon, Mary Okada, Tomoyuki |
| description | Vestibular input to the cerebellum mediates balance and eye movement control. Recent functional MRI studies, however, show midline cerebellar activation during visually induced illusions of self-rotation, thus suggesting that the cerebellum may also contribute to self-motion perception. Here, we investigate self-motion perception directly in patients with vermal (or midline) cerebellar ataxia. Participants were rotated in the dark (90°/s velocity steps) and the time constant of decay of the postrotational angular velocity sensation was measured. The perceptual vestibular time constant in patients was considerably reduced (7.8 s) with respect to control values in this (25.6 s) and several previous studies. In addition to the processing of vestibular signals for motor control, the cerebellar vermis is involved in vestibular processing of self-motion perception. |
| doi_str_mv | 10.1097/WNR.0b013e3282fbf9f6 |
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In addition to the processing of vestibular signals for motor control, the cerebellar vermis is involved in vestibular processing of self-motion perception.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cerebellar Ataxia - physiopathology</subject><subject>Eye Movements - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motion Perception - physiology</subject><subject>Rotation</subject><subject>Sensation - physiology</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. 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Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motion Perception - physiology</topic><topic>Rotation</topic><topic>Sensation - physiology</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bronstein, Adolfo M</creatorcontrib><creatorcontrib>Grunfeld, Elizabeth A</creatorcontrib><creatorcontrib>Faldon, Mary</creatorcontrib><creatorcontrib>Okada, Tomoyuki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bronstein, Adolfo M</au><au>Grunfeld, Elizabeth A</au><au>Faldon, Mary</au><au>Okada, Tomoyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced self-motion perception in patients with midline cerebellar lesions</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2008-04-16</date><risdate>2008</risdate><volume>19</volume><issue>6</issue><spage>691</spage><epage>693</epage><pages>691-693</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>Vestibular input to the cerebellum mediates balance and eye movement control. Recent functional MRI studies, however, show midline cerebellar activation during visually induced illusions of self-rotation, thus suggesting that the cerebellum may also contribute to self-motion perception. Here, we investigate self-motion perception directly in patients with vermal (or midline) cerebellar ataxia. Participants were rotated in the dark (90°/s velocity steps) and the time constant of decay of the postrotational angular velocity sensation was measured. The perceptual vestibular time constant in patients was considerably reduced (7.8 s) with respect to control values in this (25.6 s) and several previous studies. In addition to the processing of vestibular signals for motor control, the cerebellar vermis is involved in vestibular processing of self-motion perception.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>18382289</pmid><doi>10.1097/WNR.0b013e3282fbf9f6</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Cerebellar Ataxia - physiopathology Eye Movements - physiology Female Fundamental and applied biological sciences. Psychology Humans Male Middle Aged Motion Perception - physiology Rotation Sensation - physiology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs |
| title | Reduced self-motion perception in patients with midline cerebellar lesions |
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