18F-Fluorodeoxyglucose Positron Emission Tomography Does Not Predict Malignancy in Thyroid Nodules Cytologically Diagnosed as Follicular Neoplasm
Objective: The objective of this study was to evaluate the usefulness of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in predicting malignancy in thyroid nodules cytologically diagnosed as follicular neoplasm. Patients and Methods: A total of 46 patients with thyroid nodules larger...
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Kim, Jung Min Ryu, Jin-Sook Kim, Tae Yong Kim, Won Bae Kwon, Gui Young Gong, Gyungyub Moon, Dae Hyuk Kim, Seong Chul Hong, Suck Joon Shong, Young Kee |
| description | Objective: The objective of this study was to evaluate the usefulness of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in predicting malignancy in thyroid nodules cytologically diagnosed as follicular neoplasm.
Patients and Methods: A total of 46 patients with thyroid nodules larger than 1 cm in diameter cytologically diagnosed as follicular neoplasm at Asan Medical Center (Seoul, Korea) were included. FDG-PET images were taken in all patients before surgical resection, and the maximum standardized uptake value (SUVmax) of each nodule was measured.
Results: FDG-PET showed hypermetabolic activity of all nodules compared with normal thyroid tissue. Thirty-six patients underwent surgery, whereas 10 refused immediate operation. Fifteen patients had cancer: 11 with follicular and two each with Hürthle cell and follicular variants of papillary cancer. Twenty-one patients had benign nodules: 11 follicular adenomas, eight adenomatous hyperplasias, and two Hürthle cell adenomas. SUVmax did not differ significantly between malignant and benign nodules (3.6 ± 3.5 vs. 3.4 ± 3.2; P = 0.83) or among subtypes of benign nodules (P = 0.23). However, SUVmax differed significantly among subtypes of malignant nodules (P = 0.02).
Conclusions: On FDG-PET, the glucose metabolic activities of benign thyroid follicular nodules were as high as those of malignant nodules. These findings suggest that FDG-PET has limited value for selecting candidates for surgery among patients cytologically diagnosed as follicular neoplasm. |
| doi_str_mv | 10.1210/jc.2006-2311 |
| format | Article |
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Patients and Methods: A total of 46 patients with thyroid nodules larger than 1 cm in diameter cytologically diagnosed as follicular neoplasm at Asan Medical Center (Seoul, Korea) were included. FDG-PET images were taken in all patients before surgical resection, and the maximum standardized uptake value (SUVmax) of each nodule was measured.
Results: FDG-PET showed hypermetabolic activity of all nodules compared with normal thyroid tissue. Thirty-six patients underwent surgery, whereas 10 refused immediate operation. Fifteen patients had cancer: 11 with follicular and two each with Hürthle cell and follicular variants of papillary cancer. Twenty-one patients had benign nodules: 11 follicular adenomas, eight adenomatous hyperplasias, and two Hürthle cell adenomas. SUVmax did not differ significantly between malignant and benign nodules (3.6 ± 3.5 vs. 3.4 ± 3.2; P = 0.83) or among subtypes of benign nodules (P = 0.23). However, SUVmax differed significantly among subtypes of malignant nodules (P = 0.02).
Conclusions: On FDG-PET, the glucose metabolic activities of benign thyroid follicular nodules were as high as those of malignant nodules. These findings suggest that FDG-PET has limited value for selecting candidates for surgery among patients cytologically diagnosed as follicular neoplasm.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2006-2311</identifier><identifier>PMID: 17284624</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adenoma ; Adenoma - diagnostic imaging ; Adenoma - pathology ; Adenoma - surgery ; Adenoma, Oxyphilic - diagnostic imaging ; Adenoma, Oxyphilic - pathology ; Adenoma, Oxyphilic - surgery ; Adult ; Aged ; Benign ; Biological and medical sciences ; Biopsy, Fine-Needle ; Diagnosis, Differential ; Endocrinopathies ; Female ; Fluorodeoxyglucose F18 ; Fundamental and applied biological sciences. Psychology ; Glucose - metabolism ; Humans ; Male ; Malignancy ; Medical sciences ; Middle Aged ; Neoplasia ; Nodules ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Patients ; Positron emission tomography ; Radiopharmaceuticals ; Surgery ; Thyroid ; Thyroid gland ; Thyroid Nodule - diagnostic imaging ; Thyroid Nodule - pathology ; Thyroid Nodule - surgery ; Thyroid. Thyroid axis (diseases) ; Tomography ; Tumors ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2007-05, Vol.92 (5), p.1630-1634</ispartof><rights>Copyright © 2007 by The Endocrine Society 2007</rights><rights>2007 INIST-CNRS</rights><rights>Copyright © 2007 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3061-ec31071b3e72e677c49ec6f554a476fc597ee68986a0dc932eb6031e0f2047753</citedby><cites>FETCH-LOGICAL-c3061-ec31071b3e72e677c49ec6f554a476fc597ee68986a0dc932eb6031e0f2047753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18747183$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17284624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jung Min</creatorcontrib><creatorcontrib>Ryu, Jin-Sook</creatorcontrib><creatorcontrib>Kim, Tae Yong</creatorcontrib><creatorcontrib>Kim, Won Bae</creatorcontrib><creatorcontrib>Kwon, Gui Young</creatorcontrib><creatorcontrib>Gong, Gyungyub</creatorcontrib><creatorcontrib>Moon, Dae Hyuk</creatorcontrib><creatorcontrib>Kim, Seong Chul</creatorcontrib><creatorcontrib>Hong, Suck Joon</creatorcontrib><creatorcontrib>Shong, Young Kee</creatorcontrib><title>18F-Fluorodeoxyglucose Positron Emission Tomography Does Not Predict Malignancy in Thyroid Nodules Cytologically Diagnosed as Follicular Neoplasm</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Objective: The objective of this study was to evaluate the usefulness of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in predicting malignancy in thyroid nodules cytologically diagnosed as follicular neoplasm.
Patients and Methods: A total of 46 patients with thyroid nodules larger than 1 cm in diameter cytologically diagnosed as follicular neoplasm at Asan Medical Center (Seoul, Korea) were included. FDG-PET images were taken in all patients before surgical resection, and the maximum standardized uptake value (SUVmax) of each nodule was measured.
Results: FDG-PET showed hypermetabolic activity of all nodules compared with normal thyroid tissue. Thirty-six patients underwent surgery, whereas 10 refused immediate operation. Fifteen patients had cancer: 11 with follicular and two each with Hürthle cell and follicular variants of papillary cancer. Twenty-one patients had benign nodules: 11 follicular adenomas, eight adenomatous hyperplasias, and two Hürthle cell adenomas. SUVmax did not differ significantly between malignant and benign nodules (3.6 ± 3.5 vs. 3.4 ± 3.2; P = 0.83) or among subtypes of benign nodules (P = 0.23). However, SUVmax differed significantly among subtypes of malignant nodules (P = 0.02).
Conclusions: On FDG-PET, the glucose metabolic activities of benign thyroid follicular nodules were as high as those of malignant nodules. These findings suggest that FDG-PET has limited value for selecting candidates for surgery among patients cytologically diagnosed as follicular neoplasm.</description><subject>Adenoma</subject><subject>Adenoma - diagnostic imaging</subject><subject>Adenoma - pathology</subject><subject>Adenoma - surgery</subject><subject>Adenoma, Oxyphilic - diagnostic imaging</subject><subject>Adenoma, Oxyphilic - pathology</subject><subject>Adenoma, Oxyphilic - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Benign</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Fine-Needle</subject><subject>Diagnosis, Differential</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasia</subject><subject>Nodules</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Patients</subject><subject>Positron emission tomography</subject><subject>Radiopharmaceuticals</subject><subject>Surgery</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid Nodule - diagnostic imaging</subject><subject>Thyroid Nodule - pathology</subject><subject>Thyroid Nodule - surgery</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Tomography</subject><subject>Tumors</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U2L1DAYB_Aiiju7evMsAXG92DVvTdqjjDsqrOseVvBWMunTboZMn27Sgv0YfmMzTGFA9JQcfsnz8s-yV4xeMc7oh5294pSqnAvGnmQrVski16zST7MVpZzlleY_z7LzGHeUMikL8Tw7Y5qXUnG5yn6zcpNv_IQBG8Bfc-cnixHIHUY3BuzJ9d7F6NLlHvfYBTM8zOQTQiS3OJK7AI2zI_lmvOt609uZuCQf5oCuSaKZfJLreUSPnbPG-_TYma5PJRpiItmg985O3gRyCzh4E_cvsmet8RFeLudF9mNzfb_-kt98__x1_fEmt4IqloMVjGq2FaA5KK2trMCqtiikkVq1tqg0gCqrUhna2Epw2CoqGNCWU6l1IS6yy-O_Q8DHCeJYp0kteG96wCnWmkoleCUSfPMX3OEU-tRbLZiSknEtZFLvj8oGjDFAWw_B7U2Ya0brQ1D1ztaHoOpDUIm_Xj6dtntoTnhJJoG3CzAxLa4NabsunlyppWblobt3R4fT8L-S-VJSHCX0DdrgehgCxHia5p-N_gFlkLkV</recordid><startdate>200705</startdate><enddate>200705</enddate><creator>Kim, Jung Min</creator><creator>Ryu, Jin-Sook</creator><creator>Kim, Tae Yong</creator><creator>Kim, Won Bae</creator><creator>Kwon, Gui Young</creator><creator>Gong, Gyungyub</creator><creator>Moon, Dae Hyuk</creator><creator>Kim, Seong Chul</creator><creator>Hong, Suck Joon</creator><creator>Shong, Young Kee</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200705</creationdate><title>18F-Fluorodeoxyglucose Positron Emission Tomography Does Not Predict Malignancy in Thyroid Nodules Cytologically Diagnosed as Follicular Neoplasm</title><author>Kim, Jung Min ; Ryu, Jin-Sook ; Kim, Tae Yong ; Kim, Won Bae ; Kwon, Gui Young ; Gong, Gyungyub ; Moon, Dae Hyuk ; Kim, Seong Chul ; Hong, Suck Joon ; Shong, Young Kee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3061-ec31071b3e72e677c49ec6f554a476fc597ee68986a0dc932eb6031e0f2047753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenoma</topic><topic>Adenoma - diagnostic imaging</topic><topic>Adenoma - pathology</topic><topic>Adenoma - surgery</topic><topic>Adenoma, Oxyphilic - diagnostic imaging</topic><topic>Adenoma, Oxyphilic - pathology</topic><topic>Adenoma, Oxyphilic - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Benign</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Fine-Needle</topic><topic>Diagnosis, Differential</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Malignancy</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasia</topic><topic>Nodules</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Patients</topic><topic>Positron emission tomography</topic><topic>Radiopharmaceuticals</topic><topic>Surgery</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid Nodule - diagnostic imaging</topic><topic>Thyroid Nodule - pathology</topic><topic>Thyroid Nodule - surgery</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Tomography</topic><topic>Tumors</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jung Min</creatorcontrib><creatorcontrib>Ryu, Jin-Sook</creatorcontrib><creatorcontrib>Kim, Tae Yong</creatorcontrib><creatorcontrib>Kim, Won Bae</creatorcontrib><creatorcontrib>Kwon, Gui Young</creatorcontrib><creatorcontrib>Gong, Gyungyub</creatorcontrib><creatorcontrib>Moon, Dae Hyuk</creatorcontrib><creatorcontrib>Kim, Seong Chul</creatorcontrib><creatorcontrib>Hong, Suck Joon</creatorcontrib><creatorcontrib>Shong, Young Kee</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jung Min</au><au>Ryu, Jin-Sook</au><au>Kim, Tae Yong</au><au>Kim, Won Bae</au><au>Kwon, Gui Young</au><au>Gong, Gyungyub</au><au>Moon, Dae Hyuk</au><au>Kim, Seong Chul</au><au>Hong, Suck Joon</au><au>Shong, Young Kee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>18F-Fluorodeoxyglucose Positron Emission Tomography Does Not Predict Malignancy in Thyroid Nodules Cytologically Diagnosed as Follicular Neoplasm</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2007-05</date><risdate>2007</risdate><volume>92</volume><issue>5</issue><spage>1630</spage><epage>1634</epage><pages>1630-1634</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Objective: The objective of this study was to evaluate the usefulness of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in predicting malignancy in thyroid nodules cytologically diagnosed as follicular neoplasm.
Patients and Methods: A total of 46 patients with thyroid nodules larger than 1 cm in diameter cytologically diagnosed as follicular neoplasm at Asan Medical Center (Seoul, Korea) were included. FDG-PET images were taken in all patients before surgical resection, and the maximum standardized uptake value (SUVmax) of each nodule was measured.
Results: FDG-PET showed hypermetabolic activity of all nodules compared with normal thyroid tissue. Thirty-six patients underwent surgery, whereas 10 refused immediate operation. Fifteen patients had cancer: 11 with follicular and two each with Hürthle cell and follicular variants of papillary cancer. Twenty-one patients had benign nodules: 11 follicular adenomas, eight adenomatous hyperplasias, and two Hürthle cell adenomas. SUVmax did not differ significantly between malignant and benign nodules (3.6 ± 3.5 vs. 3.4 ± 3.2; P = 0.83) or among subtypes of benign nodules (P = 0.23). However, SUVmax differed significantly among subtypes of malignant nodules (P = 0.02).
Conclusions: On FDG-PET, the glucose metabolic activities of benign thyroid follicular nodules were as high as those of malignant nodules. These findings suggest that FDG-PET has limited value for selecting candidates for surgery among patients cytologically diagnosed as follicular neoplasm.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>17284624</pmid><doi>10.1210/jc.2006-2311</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenoma Adenoma - diagnostic imaging Adenoma - pathology Adenoma - surgery Adenoma, Oxyphilic - diagnostic imaging Adenoma, Oxyphilic - pathology Adenoma, Oxyphilic - surgery Adult Aged Benign Biological and medical sciences Biopsy, Fine-Needle Diagnosis, Differential Endocrinopathies Female Fluorodeoxyglucose F18 Fundamental and applied biological sciences. Psychology Glucose - metabolism Humans Male Malignancy Medical sciences Middle Aged Neoplasia Nodules Non tumoral diseases. Target tissue resistance. Benign neoplasms Patients Positron emission tomography Radiopharmaceuticals Surgery Thyroid Thyroid gland Thyroid Nodule - diagnostic imaging Thyroid Nodule - pathology Thyroid Nodule - surgery Thyroid. Thyroid axis (diseases) Tomography Tumors Vertebrates: endocrinology |
| title | 18F-Fluorodeoxyglucose Positron Emission Tomography Does Not Predict Malignancy in Thyroid Nodules Cytologically Diagnosed as Follicular Neoplasm |
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