Heritability of the Iridotrabecular Angle Width Measured by Optical Coherence Tomography in Chinese Children: The Guangzhou Twin Eye Study
To estimate the heritability of the iridotrabecular angle width measured by anterior segment optical coherence tomography (ASOCT) in a classic twin study. Twins aged 8 to 16 years were identified from the Guangzhou Twin Registry. ASOCT was used to obtain one horizontal scan, and the images were anal...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 2008-04, Vol.49 (4), p.1356-1361 |
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| creator | He, Mingguang Ge, Jian Wang, Dandan Zhang, Jian Hewitt, Alex W Hur, Yoon-Mi Mackey, David A Foster, Paul J |
| description | To estimate the heritability of the iridotrabecular angle width measured by anterior segment optical coherence tomography (ASOCT) in a classic twin study.
Twins aged 8 to 16 years were identified from the Guangzhou Twin Registry. ASOCT was used to obtain one horizontal scan, and the images were analyzed with custom software. Angle width was represented by the angle opening distance (AOD) at the 500-microm anterior-to-scleral spur, as well as the angle recess area (ARA) and trabecular-iris space area (TISA) located 750 microm anterior to the scleral spur. Zygosity was confirmed by genotyping with 16 polymorphic markers in all same-sex twin pairs. Heritability was assessed by structural variance component genetic modeling after adjustment for age and sex, with the Mx program.
The mean age of the participants was 11.7 +/- 2.6 years in 305 monozygotic (MZ) and 11.8 +/- 2.4 years in 157 dizygotic (DZ) pairs. The intraclass correlation coefficients for the AOD, ARA, and TISA were 0.70, 0.75, and 0.72 in the MZ pairs and 0.34, 0.32, and 0.33 in the DZ pairs, respectively. A model with additive genetic (69.7%; 95% CI: 63.9%-74.6%) and unique environmental effects (30.3%; 95% CI: 25.4%-36.1%) was the most parsimonious for AOD. Similar results were identified for ARA and TISA.
The variance in drainage angle width in Chinese children appears to be largely attributable to genetic effects, with a heritability of approximately 70%. |
| doi_str_mv | 10.1167/iovs.07-1397 |
| format | Article |
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Twins aged 8 to 16 years were identified from the Guangzhou Twin Registry. ASOCT was used to obtain one horizontal scan, and the images were analyzed with custom software. Angle width was represented by the angle opening distance (AOD) at the 500-microm anterior-to-scleral spur, as well as the angle recess area (ARA) and trabecular-iris space area (TISA) located 750 microm anterior to the scleral spur. Zygosity was confirmed by genotyping with 16 polymorphic markers in all same-sex twin pairs. Heritability was assessed by structural variance component genetic modeling after adjustment for age and sex, with the Mx program.
The mean age of the participants was 11.7 +/- 2.6 years in 305 monozygotic (MZ) and 11.8 +/- 2.4 years in 157 dizygotic (DZ) pairs. The intraclass correlation coefficients for the AOD, ARA, and TISA were 0.70, 0.75, and 0.72 in the MZ pairs and 0.34, 0.32, and 0.33 in the DZ pairs, respectively. A model with additive genetic (69.7%; 95% CI: 63.9%-74.6%) and unique environmental effects (30.3%; 95% CI: 25.4%-36.1%) was the most parsimonious for AOD. Similar results were identified for ARA and TISA.
The variance in drainage angle width in Chinese children appears to be largely attributable to genetic effects, with a heritability of approximately 70%.</description><identifier>ISSN: 0146-0404</identifier><identifier>ISSN: 1552-5783</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.07-1397</identifier><identifier>PMID: 18385050</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Adolescent ; Asian Continental Ancestry Group - genetics ; Biological and medical sciences ; Biometry ; Child ; China - epidemiology ; Eye and associated structures. Visual pathways and centers. Vision ; Female ; Fundamental and applied biological sciences. Psychology ; Genotype ; Humans ; Inheritance Patterns ; Iris - anatomy & histology ; Male ; Medical sciences ; Models, Genetic ; Ophthalmology ; Registries ; Tomography, Optical Coherence ; Trabecular Meshwork - anatomy & histology ; Twins, Dizygotic - genetics ; Twins, Monozygotic - genetics ; Vertebrates: nervous system and sense organs</subject><ispartof>Investigative ophthalmology & visual science, 2008-04, Vol.49 (4), p.1356-1361</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-2294cc96f70b8ff99d7ce2bebd802a6f9a6e751f7f7c7a83c7527593059e0d523</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20277881$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18385050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Mingguang</creatorcontrib><creatorcontrib>Ge, Jian</creatorcontrib><creatorcontrib>Wang, Dandan</creatorcontrib><creatorcontrib>Zhang, Jian</creatorcontrib><creatorcontrib>Hewitt, Alex W</creatorcontrib><creatorcontrib>Hur, Yoon-Mi</creatorcontrib><creatorcontrib>Mackey, David A</creatorcontrib><creatorcontrib>Foster, Paul J</creatorcontrib><title>Heritability of the Iridotrabecular Angle Width Measured by Optical Coherence Tomography in Chinese Children: The Guangzhou Twin Eye Study</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>To estimate the heritability of the iridotrabecular angle width measured by anterior segment optical coherence tomography (ASOCT) in a classic twin study.
Twins aged 8 to 16 years were identified from the Guangzhou Twin Registry. ASOCT was used to obtain one horizontal scan, and the images were analyzed with custom software. Angle width was represented by the angle opening distance (AOD) at the 500-microm anterior-to-scleral spur, as well as the angle recess area (ARA) and trabecular-iris space area (TISA) located 750 microm anterior to the scleral spur. Zygosity was confirmed by genotyping with 16 polymorphic markers in all same-sex twin pairs. Heritability was assessed by structural variance component genetic modeling after adjustment for age and sex, with the Mx program.
The mean age of the participants was 11.7 +/- 2.6 years in 305 monozygotic (MZ) and 11.8 +/- 2.4 years in 157 dizygotic (DZ) pairs. The intraclass correlation coefficients for the AOD, ARA, and TISA were 0.70, 0.75, and 0.72 in the MZ pairs and 0.34, 0.32, and 0.33 in the DZ pairs, respectively. A model with additive genetic (69.7%; 95% CI: 63.9%-74.6%) and unique environmental effects (30.3%; 95% CI: 25.4%-36.1%) was the most parsimonious for AOD. Similar results were identified for ARA and TISA.
The variance in drainage angle width in Chinese children appears to be largely attributable to genetic effects, with a heritability of approximately 70%.</description><subject>Adolescent</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>Biometry</subject><subject>Child</subject><subject>China - epidemiology</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>Humans</subject><subject>Inheritance Patterns</subject><subject>Iris - anatomy & histology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Models, Genetic</subject><subject>Ophthalmology</subject><subject>Registries</subject><subject>Tomography, Optical Coherence</subject><subject>Trabecular Meshwork - anatomy & histology</subject><subject>Twins, Dizygotic - genetics</subject><subject>Twins, Monozygotic - genetics</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0146-0404</issn><issn>1552-5783</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0DFv1DAYxnELgei1sDEjLzCRYjtxbLNVp9JWKurAIUbLcV5fjJz4sBOi8BH41M2pJzq9y0-PrT9C7yi5pLQWn338ky-JKGipxAu0oZyzggtZvkQbQqu6IBWpztB5zr8IYZQy8hqdUVlKTjjZoH-3kPxoGh_8uODo8NgBvku-jWMyDdgpmISvhn0A_NO3Y4e_gclTghY3C344jN6agLexgwSDBbyLfdwnc-gW7Ae87fwAGY43tCv4gnfr-s1khv3fLk54N6_oegH8fZza5Q165UzI8PZ0L9CPr9e77W1x_3Bzt726L2zJyVgwpiprVe0EaaRzSrXCAmugaSVhpnbK1CA4dcIJK4wsreBMcFUSroC0nJUX6OPT7iHF3xPkUfc-WwjBDBCnrAWpaiYlX-GnJ2hTzDmB04fke5MWTYk-ttfH9poIfWy_8ven3anpoX3Gp9gr-HACJq_ZXDKD9fm_Y4QJISV9_mDn993sE-jcmxDWWarnea6UrtYXeV0-As0am9s</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>He, Mingguang</creator><creator>Ge, Jian</creator><creator>Wang, Dandan</creator><creator>Zhang, Jian</creator><creator>Hewitt, Alex W</creator><creator>Hur, Yoon-Mi</creator><creator>Mackey, David A</creator><creator>Foster, Paul J</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Heritability of the Iridotrabecular Angle Width Measured by Optical Coherence Tomography in Chinese Children: The Guangzhou Twin Eye Study</title><author>He, Mingguang ; Ge, Jian ; Wang, Dandan ; Zhang, Jian ; Hewitt, Alex W ; Hur, Yoon-Mi ; Mackey, David A ; Foster, Paul J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-2294cc96f70b8ff99d7ce2bebd802a6f9a6e751f7f7c7a83c7527593059e0d523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biological and medical sciences</topic><topic>Biometry</topic><topic>Child</topic><topic>China - epidemiology</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>Humans</topic><topic>Inheritance Patterns</topic><topic>Iris - anatomy & histology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Models, Genetic</topic><topic>Ophthalmology</topic><topic>Registries</topic><topic>Tomography, Optical Coherence</topic><topic>Trabecular Meshwork - anatomy & histology</topic><topic>Twins, Dizygotic - genetics</topic><topic>Twins, Monozygotic - genetics</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Mingguang</creatorcontrib><creatorcontrib>Ge, Jian</creatorcontrib><creatorcontrib>Wang, Dandan</creatorcontrib><creatorcontrib>Zhang, Jian</creatorcontrib><creatorcontrib>Hewitt, Alex W</creatorcontrib><creatorcontrib>Hur, Yoon-Mi</creatorcontrib><creatorcontrib>Mackey, David A</creatorcontrib><creatorcontrib>Foster, Paul J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Mingguang</au><au>Ge, Jian</au><au>Wang, Dandan</au><au>Zhang, Jian</au><au>Hewitt, Alex W</au><au>Hur, Yoon-Mi</au><au>Mackey, David A</au><au>Foster, Paul J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heritability of the Iridotrabecular Angle Width Measured by Optical Coherence Tomography in Chinese Children: The Guangzhou Twin Eye Study</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>49</volume><issue>4</issue><spage>1356</spage><epage>1361</epage><pages>1356-1361</pages><issn>0146-0404</issn><issn>1552-5783</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>To estimate the heritability of the iridotrabecular angle width measured by anterior segment optical coherence tomography (ASOCT) in a classic twin study.
Twins aged 8 to 16 years were identified from the Guangzhou Twin Registry. ASOCT was used to obtain one horizontal scan, and the images were analyzed with custom software. Angle width was represented by the angle opening distance (AOD) at the 500-microm anterior-to-scleral spur, as well as the angle recess area (ARA) and trabecular-iris space area (TISA) located 750 microm anterior to the scleral spur. Zygosity was confirmed by genotyping with 16 polymorphic markers in all same-sex twin pairs. Heritability was assessed by structural variance component genetic modeling after adjustment for age and sex, with the Mx program.
The mean age of the participants was 11.7 +/- 2.6 years in 305 monozygotic (MZ) and 11.8 +/- 2.4 years in 157 dizygotic (DZ) pairs. The intraclass correlation coefficients for the AOD, ARA, and TISA were 0.70, 0.75, and 0.72 in the MZ pairs and 0.34, 0.32, and 0.33 in the DZ pairs, respectively. A model with additive genetic (69.7%; 95% CI: 63.9%-74.6%) and unique environmental effects (30.3%; 95% CI: 25.4%-36.1%) was the most parsimonious for AOD. Similar results were identified for ARA and TISA.
The variance in drainage angle width in Chinese children appears to be largely attributable to genetic effects, with a heritability of approximately 70%.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>18385050</pmid><doi>10.1167/iovs.07-1397</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Asian Continental Ancestry Group - genetics Biological and medical sciences Biometry Child China - epidemiology Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Genotype Humans Inheritance Patterns Iris - anatomy & histology Male Medical sciences Models, Genetic Ophthalmology Registries Tomography, Optical Coherence Trabecular Meshwork - anatomy & histology Twins, Dizygotic - genetics Twins, Monozygotic - genetics Vertebrates: nervous system and sense organs |
| title | Heritability of the Iridotrabecular Angle Width Measured by Optical Coherence Tomography in Chinese Children: The Guangzhou Twin Eye Study |
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