Reactive peripheral blood plasmacytosis in a patient with acute hepatitis A
Reactive plasmacytosis is a transient expansion of plasma cell progenitors and precursors. This rare condition has been reported to occur mainly in infections and tumors. We describe a case of acute hepatitis A presenting with marked peripheral blood plasmacytosis. Plasma cells made up 27.5% of the...
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| Veröffentlicht in: | International journal of hematology 2007-04, Vol.85 (3), p.191-194 |
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| container_title | International journal of hematology |
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| creator | WADA, Taizo MAEBA, Hideaki SAKAI, Yoshio KANEKO, Shuichi YACHIE, Akihiro IKAWA, Yasuhiro HASHIDA, Yoko OKUMURA, Akiko SHIBATA, Fumie TONE, Yumi INOUE, Masayuki KOIZUMI, Shoichi TAKATORI, Hajime |
| description | Reactive plasmacytosis is a transient expansion of plasma cell progenitors and precursors. This rare condition has been reported to occur mainly in infections and tumors. We describe a case of acute hepatitis A presenting with marked peripheral blood plasmacytosis. Plasma cells made up 27.5% of the mononuclear cells and had the immunophenotype CD10-CD19+CD20-CD21-CD23-CD34-CD38++HLA-DR+. Although the level of interleukin 6 was not increased, the presence of activated T-cells with an inverted CD4/CD8 ratio and high levels of soluble interleukin 2 receptor and neopterin indicated a marked immune response to acute hepatitis A. The patient's plasma cells had almost disappeared from the blood by hospital day 16. This report may represent the first described case of reactive peripheral blood plasmacytosis in acute hepatitis A. |
| doi_str_mv | 10.1532/IJH97.06200 |
| format | Article |
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This rare condition has been reported to occur mainly in infections and tumors. We describe a case of acute hepatitis A presenting with marked peripheral blood plasmacytosis. Plasma cells made up 27.5% of the mononuclear cells and had the immunophenotype CD10-CD19+CD20-CD21-CD23-CD34-CD38++HLA-DR+. Although the level of interleukin 6 was not increased, the presence of activated T-cells with an inverted CD4/CD8 ratio and high levels of soluble interleukin 2 receptor and neopterin indicated a marked immune response to acute hepatitis A. The patient's plasma cells had almost disappeared from the blood by hospital day 16. This report may represent the first described case of reactive peripheral blood plasmacytosis in acute hepatitis A.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1532/IJH97.06200</identifier><identifier>PMID: 17483053</identifier><language>eng</language><publisher>Tokyo: Springer</publisher><subject>Acute Disease ; Adolescent ; Biological and medical sciences ; Flow Cytometry ; Hematologic and hematopoietic diseases ; Hepatitis A - blood ; Human viral diseases ; Humans ; Infectious diseases ; Leukocyte Count - classification ; Male ; Medical sciences ; Other diseases. Hematologic involvement in other diseases ; Plasma Cells - virology ; Viral diseases ; Viral hepatitis</subject><ispartof>International journal of hematology, 2007-04, Vol.85 (3), p.191-194</ispartof><rights>2007 INIST-CNRS</rights><rights>The Japanese Society of Hematology 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-d5f0080a11366314d98b667e8f66bbcf7970fd62fbf008aaf589ddac39fb5fa53</citedby><cites>FETCH-LOGICAL-c412t-d5f0080a11366314d98b667e8f66bbcf7970fd62fbf008aaf589ddac39fb5fa53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18738954$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17483053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WADA, Taizo</creatorcontrib><creatorcontrib>MAEBA, Hideaki</creatorcontrib><creatorcontrib>SAKAI, Yoshio</creatorcontrib><creatorcontrib>KANEKO, Shuichi</creatorcontrib><creatorcontrib>YACHIE, Akihiro</creatorcontrib><creatorcontrib>IKAWA, Yasuhiro</creatorcontrib><creatorcontrib>HASHIDA, Yoko</creatorcontrib><creatorcontrib>OKUMURA, Akiko</creatorcontrib><creatorcontrib>SHIBATA, Fumie</creatorcontrib><creatorcontrib>TONE, Yumi</creatorcontrib><creatorcontrib>INOUE, Masayuki</creatorcontrib><creatorcontrib>KOIZUMI, Shoichi</creatorcontrib><creatorcontrib>TAKATORI, Hajime</creatorcontrib><title>Reactive peripheral blood plasmacytosis in a patient with acute hepatitis A</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><description>Reactive plasmacytosis is a transient expansion of plasma cell progenitors and precursors. This rare condition has been reported to occur mainly in infections and tumors. We describe a case of acute hepatitis A presenting with marked peripheral blood plasmacytosis. Plasma cells made up 27.5% of the mononuclear cells and had the immunophenotype CD10-CD19+CD20-CD21-CD23-CD34-CD38++HLA-DR+. Although the level of interleukin 6 was not increased, the presence of activated T-cells with an inverted CD4/CD8 ratio and high levels of soluble interleukin 2 receptor and neopterin indicated a marked immune response to acute hepatitis A. The patient's plasma cells had almost disappeared from the blood by hospital day 16. This report may represent the first described case of reactive peripheral blood plasmacytosis in acute hepatitis A.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Flow Cytometry</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hepatitis A - blood</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Leukocyte Count - classification</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other diseases. 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This rare condition has been reported to occur mainly in infections and tumors. We describe a case of acute hepatitis A presenting with marked peripheral blood plasmacytosis. Plasma cells made up 27.5% of the mononuclear cells and had the immunophenotype CD10-CD19+CD20-CD21-CD23-CD34-CD38++HLA-DR+. Although the level of interleukin 6 was not increased, the presence of activated T-cells with an inverted CD4/CD8 ratio and high levels of soluble interleukin 2 receptor and neopterin indicated a marked immune response to acute hepatitis A. The patient's plasma cells had almost disappeared from the blood by hospital day 16. This report may represent the first described case of reactive peripheral blood plasmacytosis in acute hepatitis A.</abstract><cop>Tokyo</cop><pub>Springer</pub><pmid>17483053</pmid><doi>10.1532/IJH97.06200</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of hematology, 2007-04, Vol.85 (3), p.191-194 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acute Disease Adolescent Biological and medical sciences Flow Cytometry Hematologic and hematopoietic diseases Hepatitis A - blood Human viral diseases Humans Infectious diseases Leukocyte Count - classification Male Medical sciences Other diseases. Hematologic involvement in other diseases Plasma Cells - virology Viral diseases Viral hepatitis |
| title | Reactive peripheral blood plasmacytosis in a patient with acute hepatitis A |
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