A novel, tissue occlusive poly(ethylene glycol) hydrogel material
The use of guided bone regeneration (GBR) techniques requires new materials meeting the needs of clinical application. Design criteria for GBR devices are biocompatibility, tissue occlusion, space provision, and clinical manageability. This study evaluates a novel biodegradable poly (ethylene glycol...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2008-05, Vol.85A (2), p.285-292 |
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| container_title | Journal of biomedical materials research. Part A |
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| creator | Wechsler, Sandra Fehr, Daniel Molenberg, Aart Raeber, George Schense, Jason C. Weber, Franz E. |
| description | The use of guided bone regeneration (GBR) techniques requires new materials meeting the needs of clinical application. Design criteria for GBR devices are biocompatibility, tissue occlusion, space provision, and clinical manageability. This study evaluates a novel biodegradable poly (ethylene glycol) (PEG) based material as tissue occlusive membrane. A subcutaneous implant model in rats was developed to test the barrier function of the PEG hydrogels over time. Fourteen rats received three membrane implants and two positive controls each. Explants were collected over a period of 7 months. Histological analysis revealed that for at least 4 months cellular infiltration in the membrane explants was lower than 1% of that of the positive controls. Therefore, the PEG based hydrogel can be regarded as tissue occlusive during this period of time. A barrier function seems to be maintained for up to 6 months. In vitro degradation studies performed with the same PEG constructs confirm the in vivo result. In conclusion, our results indicate that this novel PEG‐based material has potential for use as a GBR barrier membrane. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008 |
| doi_str_mv | 10.1002/jbm.a.31477 |
| format | Article |
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Design criteria for GBR devices are biocompatibility, tissue occlusion, space provision, and clinical manageability. This study evaluates a novel biodegradable poly (ethylene glycol) (PEG) based material as tissue occlusive membrane. A subcutaneous implant model in rats was developed to test the barrier function of the PEG hydrogels over time. Fourteen rats received three membrane implants and two positive controls each. Explants were collected over a period of 7 months. Histological analysis revealed that for at least 4 months cellular infiltration in the membrane explants was lower than 1% of that of the positive controls. Therefore, the PEG based hydrogel can be regarded as tissue occlusive during this period of time. A barrier function seems to be maintained for up to 6 months. In vitro degradation studies performed with the same PEG constructs confirm the in vivo result. 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Part A</title><addtitle>J. Biomed. Mater. Res</addtitle><description>The use of guided bone regeneration (GBR) techniques requires new materials meeting the needs of clinical application. Design criteria for GBR devices are biocompatibility, tissue occlusion, space provision, and clinical manageability. This study evaluates a novel biodegradable poly (ethylene glycol) (PEG) based material as tissue occlusive membrane. A subcutaneous implant model in rats was developed to test the barrier function of the PEG hydrogels over time. Fourteen rats received three membrane implants and two positive controls each. Explants were collected over a period of 7 months. Histological analysis revealed that for at least 4 months cellular infiltration in the membrane explants was lower than 1% of that of the positive controls. Therefore, the PEG based hydrogel can be regarded as tissue occlusive during this period of time. A barrier function seems to be maintained for up to 6 months. In vitro degradation studies performed with the same PEG constructs confirm the in vivo result. In conclusion, our results indicate that this novel PEG‐based material has potential for use as a GBR barrier membrane. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008</description><subject>animal model</subject><subject>Animals</subject><subject>Bone Regeneration</subject><subject>dental implant</subject><subject>Female</subject><subject>Guided Tissue Regeneration - methods</subject><subject>hydrogel</subject><subject>Hydrogels</subject><subject>Materials Testing - methods</subject><subject>Membranes, Artificial</subject><subject>Polyethylene Glycols</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Time Factors</subject><issn>1549-3296</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlOwzAQQC0EYj9xRzkhEKR4j30sFVvFIiQQEhfLcaYQcJoSJ4X8PYEWuMFp5vDmjfQQ2iK4RzCmh89p0bM9RniSLKBVIgSNuZZi8XPnOmZUyxW0FsJzB0ss6DJaIYlUimq2ivr9aFxOwR9EdR5CA1HpnG9CPoVoUvp2F-qn1sMYokffutLvRU9tVpWP4KPC1lDl1m-gpZH1ATbncx3dnRzfDs7ii-vT80H_InaciSQWmWWQqO6_yDiXo5RLTBzNmGVKMEGtEtRpa52yWKvMKYHTVDurGeaUKc3W0c7MO6nK1wZCbYo8OPDejqFsgkkwl5Rz8S_IqOCEctKB-zPQVWUIFYzMpMoLW7WGYPOZ1nRpjTVfaTt6e65t0gKyX3besgPIDHjLPbR_uczw6PJbGs9u8lDD-8-NrV6MTFgizP3VqcFDeftwMhiaG_YBA3CR6Q</recordid><startdate>200805</startdate><enddate>200805</enddate><creator>Wechsler, Sandra</creator><creator>Fehr, Daniel</creator><creator>Molenberg, Aart</creator><creator>Raeber, George</creator><creator>Schense, Jason C.</creator><creator>Weber, Franz E.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>200805</creationdate><title>A novel, tissue occlusive poly(ethylene glycol) hydrogel material</title><author>Wechsler, Sandra ; Fehr, Daniel ; Molenberg, Aart ; Raeber, George ; Schense, Jason C. ; Weber, Franz E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4357-5da3e780525d446fb4601c2d3a385352a852c9aac8a098dc850bb9ca930423893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>animal model</topic><topic>Animals</topic><topic>Bone Regeneration</topic><topic>dental implant</topic><topic>Female</topic><topic>Guided Tissue Regeneration - methods</topic><topic>hydrogel</topic><topic>Hydrogels</topic><topic>Materials Testing - methods</topic><topic>Membranes, Artificial</topic><topic>Polyethylene Glycols</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wechsler, Sandra</creatorcontrib><creatorcontrib>Fehr, Daniel</creatorcontrib><creatorcontrib>Molenberg, Aart</creatorcontrib><creatorcontrib>Raeber, George</creatorcontrib><creatorcontrib>Schense, Jason C.</creatorcontrib><creatorcontrib>Weber, Franz E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wechsler, Sandra</au><au>Fehr, Daniel</au><au>Molenberg, Aart</au><au>Raeber, George</au><au>Schense, Jason C.</au><au>Weber, Franz E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel, tissue occlusive poly(ethylene glycol) hydrogel material</atitle><jtitle>Journal of biomedical materials research. Part A</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2008-05</date><risdate>2008</risdate><volume>85A</volume><issue>2</issue><spage>285</spage><epage>292</epage><pages>285-292</pages><issn>1549-3296</issn><eissn>1552-4965</eissn><abstract>The use of guided bone regeneration (GBR) techniques requires new materials meeting the needs of clinical application. Design criteria for GBR devices are biocompatibility, tissue occlusion, space provision, and clinical manageability. This study evaluates a novel biodegradable poly (ethylene glycol) (PEG) based material as tissue occlusive membrane. A subcutaneous implant model in rats was developed to test the barrier function of the PEG hydrogels over time. Fourteen rats received three membrane implants and two positive controls each. Explants were collected over a period of 7 months. Histological analysis revealed that for at least 4 months cellular infiltration in the membrane explants was lower than 1% of that of the positive controls. Therefore, the PEG based hydrogel can be regarded as tissue occlusive during this period of time. A barrier function seems to be maintained for up to 6 months. In vitro degradation studies performed with the same PEG constructs confirm the in vivo result. In conclusion, our results indicate that this novel PEG‐based material has potential for use as a GBR barrier membrane. © 2007 Wiley Periodicals, Inc. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | animal model Animals Bone Regeneration dental implant Female Guided Tissue Regeneration - methods hydrogel Hydrogels Materials Testing - methods Membranes, Artificial Polyethylene Glycols Rats Rats, Sprague-Dawley Time Factors |
| title | A novel, tissue occlusive poly(ethylene glycol) hydrogel material |
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