Construction of anti-EGFR immunoliposomes via folate–folate binding protein affinity

A novel method for synthesis of anti-EGFR immunoliposomes using folate–folate binding protein (FBP) affinity is described. An anti-EGFR antibody (cetuximab or C225) was covalently linked to FBP via a thioether bond. Liposomes incorporating a lipophilic folate derivative (folate-PEG-cholesterol) were...

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Veröffentlicht in:	International journal of pharmaceutics 2007-05, Vol.336 (2), p.276-283
Hauptverfasser:	Pan, Xiaogang, Lee, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Biological and medical sciences Biological Transport Carrier Proteins - administration & dosage Carrier Proteins - pharmacology Cell Line, Tumor Cetuximab Doxorubicin - administration & dosage Doxorubicin - pharmacology Drug Delivery Systems Drug Stability Drug targeting EGF receptor Flow Cytometry Folate Folate binding protein Folate Receptors, GPI-Anchored Folic Acid General pharmacology Glioblastoma Humans Hydrogen-Ion Concentration Immunoconjugates - administration & dosage Immunoconjugates - pharmacology Immunoliposomes Liposomes Medical sciences Microscopy, Fluorescence Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polycarboxylate Cement Receptor, Epidermal Growth Factor - drug effects Receptor, Epidermal Growth Factor - immunology Receptor, Epidermal Growth Factor - metabolism Receptors, Cell Surface - administration & dosage
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