The influence of levosimendan and iloprost on renal ischemia-reperfusion: an experimental study
Department of Cardiovascular Surgery, Atatürk Education and Research Hospital, Izmir, Turkey *Corresponding author. 2/11 sok. No: 7 D: 18 Oyak Sitesi, Izmir, Turkey. Fax: +90 232 2434848. E-mail address : hyasa20{at}yahoo.com (H. Yasa). The effects of iloprost on ischemia–reperfusion injury have bee...
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| Veröffentlicht in: | Interactive cardiovascular and thoracic surgery 2008-04, Vol.7 (2), p.235-239 |
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| creator | Yakut, Necmettin Yasa, Haydar Bahriye Lafci, Banu Ortac, Ragip Tulukoglu, Engin Aksun, Murat Ozbek, Cengiz Gurbuz, Ali |
| description | Department of Cardiovascular Surgery, Atatürk Education and Research Hospital, Izmir, Turkey
*Corresponding author. 2/11 sok. No: 7 D: 18 Oyak Sitesi, Izmir, Turkey. Fax: +90 232 2434848. E-mail address : hyasa20{at}yahoo.com (H. Yasa).
The effects of iloprost on ischemia–reperfusion injury have been studied on the skeletal, muscle, liver, myocardium, kidney, and spinal cord. However, no sufficient data exist about effects of levosimendan on renal ischemia–reperfusion injury. The purpose of this experimental study was to investigate and compare effectiveness of levosimendan and iloprost on renal injury induced by ischemia and reperfusion. Fifty rabbits were divided into five groups. Levosimendan was continuously infused starting half an hour before the cross-clamp. Cross-clamp time was one hour. After one hour ischemia, levosimendan was continued for 4 h in Group A whereas Group B took iloprost in the same protocol. Group C was the control group which did not receive any medication. Group D was sham group and Group E was medicated both iloprost and levosimendan. Renal tissues were histologically and biochemically evaluated. The histological scores were obtained according to presence of tubuler necrosis and atrophy, regenerative atypia, hydropic degeneration (Group A vs. Group C |
| doi_str_mv | 10.1510/icvts.2007.161356 |
| format | Article |
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*Corresponding author. 2/11 sok. No: 7 D: 18 Oyak Sitesi, Izmir, Turkey. Fax: +90 232 2434848. E-mail address : hyasa20{at}yahoo.com (H. Yasa).
The effects of iloprost on ischemia–reperfusion injury have been studied on the skeletal, muscle, liver, myocardium, kidney, and spinal cord. However, no sufficient data exist about effects of levosimendan on renal ischemia–reperfusion injury. The purpose of this experimental study was to investigate and compare effectiveness of levosimendan and iloprost on renal injury induced by ischemia and reperfusion. Fifty rabbits were divided into five groups. Levosimendan was continuously infused starting half an hour before the cross-clamp. Cross-clamp time was one hour. After one hour ischemia, levosimendan was continued for 4 h in Group A whereas Group B took iloprost in the same protocol. Group C was the control group which did not receive any medication. Group D was sham group and Group E was medicated both iloprost and levosimendan. Renal tissues were histologically and biochemically evaluated. The histological scores were obtained according to presence of tubuler necrosis and atrophy, regenerative atypia, hydropic degeneration (Group A vs. Group C<0.001, Group B vs. Group C<0.001, Group D vs. Group C<0.01, Group E vs. Group C<0.001). Mean malondialdehyde levels were 114±12 nmol/g tissue; in Group A 121±13 nmol/g tissue, in Group B 134±13 nmol/g tissue, in Group E 130±11 nmol/g tissue, in Group D 134±11 nmol/g tissue (Group A vs. Group B; P =0.003, Group B vs. Group D; P =0.132, Group A vs. Group E; P =0.132). Malondialdehyde levels and histologic scores of all of the groups were significantly different from the control group. Iloprost and pentoxyfillin reduced renal ischemia–reperfusion injury in rabbit model. There was no significant difference between these two medications.
Key Words: Iloprost; Levosimendan; Ischemia/reperfusion injury; Rabbit kidney</description><identifier>ISSN: 1569-9293</identifier><identifier>EISSN: 1569-9285</identifier><identifier>DOI: 10.1510/icvts.2007.161356</identifier><identifier>PMID: 18056154</identifier><language>eng</language><publisher>England: Eur Assoc Cardio Surg</publisher><subject>Animals ; Atrophy ; Disease Models, Animal ; Female ; Hydrazones - pharmacology ; Hydrazones - therapeutic use ; Iloprost - pharmacology ; Iloprost - therapeutic use ; Kidney - blood supply ; Kidney - drug effects ; Kidney - metabolism ; Kidney - pathology ; Kidney Diseases - metabolism ; Kidney Diseases - pathology ; Kidney Diseases - prevention & control ; Lipid Peroxidation - drug effects ; Male ; Malondialdehyde - metabolism ; Necrosis ; Protective Agents - pharmacology ; Protective Agents - therapeutic use ; Pyridazines - pharmacology ; Pyridazines - therapeutic use ; Rabbits ; Reperfusion Injury - metabolism ; Reperfusion Injury - pathology ; Reperfusion Injury - prevention & control</subject><ispartof>Interactive cardiovascular and thoracic surgery, 2008-04, Vol.7 (2), p.235-239</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2886-e8d339df1be26b5a756b57eebe9380a36f9302cceb8e78bc5be3c388fd6fd1df3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18056154$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yakut, Necmettin</creatorcontrib><creatorcontrib>Yasa, Haydar</creatorcontrib><creatorcontrib>Bahriye Lafci, Banu</creatorcontrib><creatorcontrib>Ortac, Ragip</creatorcontrib><creatorcontrib>Tulukoglu, Engin</creatorcontrib><creatorcontrib>Aksun, Murat</creatorcontrib><creatorcontrib>Ozbek, Cengiz</creatorcontrib><creatorcontrib>Gurbuz, Ali</creatorcontrib><title>The influence of levosimendan and iloprost on renal ischemia-reperfusion: an experimental study</title><title>Interactive cardiovascular and thoracic surgery</title><addtitle>Interact Cardiovasc Thorac Surg</addtitle><description>Department of Cardiovascular Surgery, Atatürk Education and Research Hospital, Izmir, Turkey
*Corresponding author. 2/11 sok. No: 7 D: 18 Oyak Sitesi, Izmir, Turkey. Fax: +90 232 2434848. E-mail address : hyasa20{at}yahoo.com (H. Yasa).
The effects of iloprost on ischemia–reperfusion injury have been studied on the skeletal, muscle, liver, myocardium, kidney, and spinal cord. However, no sufficient data exist about effects of levosimendan on renal ischemia–reperfusion injury. The purpose of this experimental study was to investigate and compare effectiveness of levosimendan and iloprost on renal injury induced by ischemia and reperfusion. Fifty rabbits were divided into five groups. Levosimendan was continuously infused starting half an hour before the cross-clamp. Cross-clamp time was one hour. After one hour ischemia, levosimendan was continued for 4 h in Group A whereas Group B took iloprost in the same protocol. Group C was the control group which did not receive any medication. Group D was sham group and Group E was medicated both iloprost and levosimendan. Renal tissues were histologically and biochemically evaluated. The histological scores were obtained according to presence of tubuler necrosis and atrophy, regenerative atypia, hydropic degeneration (Group A vs. Group C<0.001, Group B vs. Group C<0.001, Group D vs. Group C<0.01, Group E vs. Group C<0.001). Mean malondialdehyde levels were 114±12 nmol/g tissue; in Group A 121±13 nmol/g tissue, in Group B 134±13 nmol/g tissue, in Group E 130±11 nmol/g tissue, in Group D 134±11 nmol/g tissue (Group A vs. Group B; P =0.003, Group B vs. Group D; P =0.132, Group A vs. Group E; P =0.132). Malondialdehyde levels and histologic scores of all of the groups were significantly different from the control group. Iloprost and pentoxyfillin reduced renal ischemia–reperfusion injury in rabbit model. There was no significant difference between these two medications.
Key Words: Iloprost; Levosimendan; Ischemia/reperfusion injury; Rabbit kidney</description><subject>Animals</subject><subject>Atrophy</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Hydrazones - pharmacology</subject><subject>Hydrazones - therapeutic use</subject><subject>Iloprost - pharmacology</subject><subject>Iloprost - therapeutic use</subject><subject>Kidney - blood supply</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidney Diseases - metabolism</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Diseases - prevention & control</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Necrosis</subject><subject>Protective Agents - pharmacology</subject><subject>Protective Agents - therapeutic use</subject><subject>Pyridazines - pharmacology</subject><subject>Pyridazines - therapeutic use</subject><subject>Rabbits</subject><subject>Reperfusion Injury - metabolism</subject><subject>Reperfusion Injury - pathology</subject><subject>Reperfusion Injury - prevention & control</subject><issn>1569-9293</issn><issn>1569-9285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPxCAUhYnROL5-gBvDyl1HHgOl7ozxlZi40TWhcHEwlI6l9fHvZZyJbriQfOdw7kHolJI5FZRcBPsx5jkjpJ5TSbmQO-iACtlUDVNi9-_e8Bk6zPmNENoQTvbRjCoiJBWLA6Sfl4BD8nGCZAH3Hkf46HPoIDmTsEkOh9ivhj6PuE94gGQiDtkuoQumGmAFg59y6NNlYTF8lfdaOxYqj5P7PkZ73sQMJ9t5hF5ub56v76vHp7uH66vHyjKlZAXKcd44T1tgshWmFuWsAVpouCKGS99wwqyFVkGtWita4JYr5Z30jjrPj9D5xrdEfZ8gj7orKSFGk6Cfsq7JQhLBaAHpBrRlpzyA16uS2AzfmhK9blX_tqrXrepNq0VztjWf2g7cv2Jb4__vy_C6_AwD6NyZGAvONna1ZppxwX8AMHGEZg</recordid><startdate>200804</startdate><enddate>200804</enddate><creator>Yakut, Necmettin</creator><creator>Yasa, Haydar</creator><creator>Bahriye Lafci, Banu</creator><creator>Ortac, Ragip</creator><creator>Tulukoglu, Engin</creator><creator>Aksun, Murat</creator><creator>Ozbek, Cengiz</creator><creator>Gurbuz, Ali</creator><general>Eur Assoc Cardio Surg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200804</creationdate><title>The influence of levosimendan and iloprost on renal ischemia-reperfusion: an experimental study</title><author>Yakut, Necmettin ; Yasa, Haydar ; Bahriye Lafci, Banu ; Ortac, Ragip ; Tulukoglu, Engin ; Aksun, Murat ; Ozbek, Cengiz ; Gurbuz, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2886-e8d339df1be26b5a756b57eebe9380a36f9302cceb8e78bc5be3c388fd6fd1df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Atrophy</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Hydrazones - pharmacology</topic><topic>Hydrazones - therapeutic use</topic><topic>Iloprost - pharmacology</topic><topic>Iloprost - therapeutic use</topic><topic>Kidney - blood supply</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Kidney Diseases - metabolism</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Diseases - prevention & control</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Necrosis</topic><topic>Protective Agents - pharmacology</topic><topic>Protective Agents - therapeutic use</topic><topic>Pyridazines - pharmacology</topic><topic>Pyridazines - therapeutic use</topic><topic>Rabbits</topic><topic>Reperfusion Injury - metabolism</topic><topic>Reperfusion Injury - pathology</topic><topic>Reperfusion Injury - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yakut, Necmettin</creatorcontrib><creatorcontrib>Yasa, Haydar</creatorcontrib><creatorcontrib>Bahriye Lafci, Banu</creatorcontrib><creatorcontrib>Ortac, Ragip</creatorcontrib><creatorcontrib>Tulukoglu, Engin</creatorcontrib><creatorcontrib>Aksun, Murat</creatorcontrib><creatorcontrib>Ozbek, Cengiz</creatorcontrib><creatorcontrib>Gurbuz, Ali</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Interactive cardiovascular and thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yakut, Necmettin</au><au>Yasa, Haydar</au><au>Bahriye Lafci, Banu</au><au>Ortac, Ragip</au><au>Tulukoglu, Engin</au><au>Aksun, Murat</au><au>Ozbek, Cengiz</au><au>Gurbuz, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of levosimendan and iloprost on renal ischemia-reperfusion: an experimental study</atitle><jtitle>Interactive cardiovascular and thoracic surgery</jtitle><addtitle>Interact Cardiovasc Thorac Surg</addtitle><date>2008-04</date><risdate>2008</risdate><volume>7</volume><issue>2</issue><spage>235</spage><epage>239</epage><pages>235-239</pages><issn>1569-9293</issn><eissn>1569-9285</eissn><abstract>Department of Cardiovascular Surgery, Atatürk Education and Research Hospital, Izmir, Turkey
*Corresponding author. 2/11 sok. No: 7 D: 18 Oyak Sitesi, Izmir, Turkey. Fax: +90 232 2434848. E-mail address : hyasa20{at}yahoo.com (H. Yasa).
The effects of iloprost on ischemia–reperfusion injury have been studied on the skeletal, muscle, liver, myocardium, kidney, and spinal cord. However, no sufficient data exist about effects of levosimendan on renal ischemia–reperfusion injury. The purpose of this experimental study was to investigate and compare effectiveness of levosimendan and iloprost on renal injury induced by ischemia and reperfusion. Fifty rabbits were divided into five groups. Levosimendan was continuously infused starting half an hour before the cross-clamp. Cross-clamp time was one hour. After one hour ischemia, levosimendan was continued for 4 h in Group A whereas Group B took iloprost in the same protocol. Group C was the control group which did not receive any medication. Group D was sham group and Group E was medicated both iloprost and levosimendan. Renal tissues were histologically and biochemically evaluated. The histological scores were obtained according to presence of tubuler necrosis and atrophy, regenerative atypia, hydropic degeneration (Group A vs. Group C<0.001, Group B vs. Group C<0.001, Group D vs. Group C<0.01, Group E vs. Group C<0.001). Mean malondialdehyde levels were 114±12 nmol/g tissue; in Group A 121±13 nmol/g tissue, in Group B 134±13 nmol/g tissue, in Group E 130±11 nmol/g tissue, in Group D 134±11 nmol/g tissue (Group A vs. Group B; P =0.003, Group B vs. Group D; P =0.132, Group A vs. Group E; P =0.132). Malondialdehyde levels and histologic scores of all of the groups were significantly different from the control group. Iloprost and pentoxyfillin reduced renal ischemia–reperfusion injury in rabbit model. There was no significant difference between these two medications.
Key Words: Iloprost; Levosimendan; Ischemia/reperfusion injury; Rabbit kidney</abstract><cop>England</cop><pub>Eur Assoc Cardio Surg</pub><pmid>18056154</pmid><doi>10.1510/icvts.2007.161356</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Atrophy Disease Models, Animal Female Hydrazones - pharmacology Hydrazones - therapeutic use Iloprost - pharmacology Iloprost - therapeutic use Kidney - blood supply Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Diseases - prevention & control Lipid Peroxidation - drug effects Male Malondialdehyde - metabolism Necrosis Protective Agents - pharmacology Protective Agents - therapeutic use Pyridazines - pharmacology Pyridazines - therapeutic use Rabbits Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - prevention & control |
| title | The influence of levosimendan and iloprost on renal ischemia-reperfusion: an experimental study |
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