TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels

Aims/hypothesis The gene encoding transcription factor 7-like 2 (TCF7L2) has been identified as a type 2 diabetes locus from genome-wide linkage studies and subsequent association analysis. We investigated the role of two common variants in TCF7L2 in a large case-control study recruited from the Tay...

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Veröffentlicht in:	Diabetologia 2007-06, Vol.50 (6), p.1186-1191
Hauptverfasser:	Kimber, C. H, Doney, A. S. F, Pearson, E. R, McCarthy, M. I, Hattersley, A. T, Leese, G. P, Morris, A. D, Palmer, C. N. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences biological resistance Biomedical research Blood Glucose - metabolism Body Mass Index Body Size Cholesterol Diabetes Diabetes Mellitus - blood Diabetes Mellitus - genetics Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance disease severity DNA Primers Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Gene Dosage Genes Genetic Predisposition to Disease Genetic Variation genetics Genomes Glucose Glucose control HbA₁c Homeostasis Hospitals Humans Insulin Lipids - blood Medical schools Medical sciences Middle Aged noninsulin-dependent diabetes mellitus Odds Ratio Polymorphism Prevention programs Primary care Reference Values Regression analysis TCF Transcription Factors - genetics Transcription factor Transcription Factor 7-Like 2 Protein Transcription factors
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