A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agent

The most abundant and biologically active green tea catechin, (-)-epigallocatechin-3-gallate or (-)-EGCG, has been shown to act as a proteasome inhibitor and tumor cell death inducer. However, (-)-EGCG is unstable under physiologic conditions and has poor bioavailability. Previously, in an attempt t...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-05, Vol.67 (9), p.4303-4310
Hauptverfasser:	LANDIS-PIWOWAR, Kristin R, CONGDE HUO, DI CHEN, MILACIC, Vesna, GUOQING SHI, TAK HANG CHAN, PING DOU, Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - metabolism Breast Neoplasms - pathology Catechin - analogs & derivatives Catechin - pharmacokinetics Catechin - pharmacology Cell Growth Processes - drug effects Cell Line, Tumor Chromatography, High Pressure Liquid Chymotrypsin - antagonists & inhibitors Chymotrypsin - metabolism Female Humans Medical sciences Mice Mice, Nude Peracetic Acid - pharmacokinetics Peracetic Acid - pharmacology Pharmacology. Drug treatments Prodrugs - pharmacokinetics Prodrugs - pharmacology Protease Inhibitors - pharmacokinetics Protease Inhibitors - pharmacology Tumors Xenograft Model Antitumor Assays
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