Analysis of the in vitro metabolites of diferuloylmethane (curcumin) by liquid chromatography -tandem mass spectrometry on a hybrid quadrupole linear ion trap system : newly identified metabolites

In this study, we have described a novel approach for determining the metabolic scheme of diferuloylmethane (curcumin) in mouse and human liver microsomal preparations using a hybrid quadrupole linear ion trap mass spectrometer coupled with liquid chromatography for the detection of new metabolites....

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Veröffentlicht in:	European journal of drug metabolism and pharmacokinetics 2007, Vol.32 (1), p.51-57
Hauptverfasser:	TAMVAKOPOULOS, Constantin, SOFIANOS, Zacharias D, GARBIS, Spiros D, PANTAZIS, Panayotis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotransformation Chromatography, High Pressure Liquid - methods Curcumin - chemistry Curcumin - metabolism Dealkylation Glucuronides - metabolism Humans In Vitro Techniques Liver - metabolism Male Medical sciences Mice Microsomes, Liver - metabolism Molecular Structure Pharmacology. Drug treatments Plant Preparations - chemistry Plant Preparations - metabolism Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - methods Tandem Mass Spectrometry - methods
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