Gelastic Seizures Misdiagnosed as Gastroesophageal Reflux Disease
Gastroesophageal reflux disease can have variable manifestations including regurgitation, irritability, arching, choking, and apnea. The disorder is also frequently mistaken for seizures (Sandifer syndrome). We report 6 patients in whom the opposite phenomenon occurred: their seizures were mistaken...
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| Veröffentlicht in: | Clinical pediatrics 2007-05, Vol.46 (4), p.325-328 |
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| creator | Sweetman, Laura L. Ng, Yu-tze Kerrigan, John F. |
| description | Gastroesophageal reflux disease can have variable manifestations including regurgitation, irritability, arching, choking, and apnea. The disorder is also frequently mistaken for seizures (Sandifer syndrome). We report 6 patients in whom the opposite phenomenon occurred: their seizures were mistaken for gastroesophageal reflux disease. Six of 77 patients (6.8%) with gelastic seizures and epilepsy symptomatic of hypothalamic hamartomas were noted to be misdiagnosed with gastroesophageal reflux disease in infancy. As is typical in these patients, gelastic seizures were not diagnosed until months, or often years, later. Delayed diagnosis of hypothalamic hamartomas can lead to a potentially deleterious syndrome involving refractory epilepsy, developmental problems, and precocious puberty. Gelastic seizures should be considered among the conditions that can mimic reflux symptoms. |
| doi_str_mv | 10.1177/0009922806295400 |
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The disorder is also frequently mistaken for seizures (Sandifer syndrome). We report 6 patients in whom the opposite phenomenon occurred: their seizures were mistaken for gastroesophageal reflux disease. Six of 77 patients (6.8%) with gelastic seizures and epilepsy symptomatic of hypothalamic hamartomas were noted to be misdiagnosed with gastroesophageal reflux disease in infancy. As is typical in these patients, gelastic seizures were not diagnosed until months, or often years, later. Delayed diagnosis of hypothalamic hamartomas can lead to a potentially deleterious syndrome involving refractory epilepsy, developmental problems, and precocious puberty. Gelastic seizures should be considered among the conditions that can mimic reflux symptoms.</description><identifier>ISSN: 0009-9228</identifier><identifier>EISSN: 1938-2707</identifier><identifier>DOI: 10.1177/0009922806295400</identifier><identifier>PMID: 17475990</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Diagnosis, Differential ; Diagnostic Errors ; Epilepsies, Partial - pathology ; Female ; Gastroesophageal Reflux - diagnosis ; Hamartoma - pathology ; Humans ; Hypothalamic Neoplasms - pathology ; Infant ; Infant, Newborn ; Male ; Seizures</subject><ispartof>Clinical pediatrics, 2007-05, Vol.46 (4), p.325-328</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-7b750174cdaf4ce299520987713870ce3123e215a65e07a2986ce72e0c15f2f53</citedby><cites>FETCH-LOGICAL-c366t-7b750174cdaf4ce299520987713870ce3123e215a65e07a2986ce72e0c15f2f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0009922806295400$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0009922806295400$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17475990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sweetman, Laura L.</creatorcontrib><creatorcontrib>Ng, Yu-tze</creatorcontrib><creatorcontrib>Kerrigan, John F.</creatorcontrib><title>Gelastic Seizures Misdiagnosed as Gastroesophageal Reflux Disease</title><title>Clinical pediatrics</title><addtitle>Clin Pediatr (Phila)</addtitle><description>Gastroesophageal reflux disease can have variable manifestations including regurgitation, irritability, arching, choking, and apnea. The disorder is also frequently mistaken for seizures (Sandifer syndrome). We report 6 patients in whom the opposite phenomenon occurred: their seizures were mistaken for gastroesophageal reflux disease. Six of 77 patients (6.8%) with gelastic seizures and epilepsy symptomatic of hypothalamic hamartomas were noted to be misdiagnosed with gastroesophageal reflux disease in infancy. As is typical in these patients, gelastic seizures were not diagnosed until months, or often years, later. Delayed diagnosis of hypothalamic hamartomas can lead to a potentially deleterious syndrome involving refractory epilepsy, developmental problems, and precocious puberty. Gelastic seizures should be considered among the conditions that can mimic reflux symptoms.</description><subject>Diagnosis, Differential</subject><subject>Diagnostic Errors</subject><subject>Epilepsies, Partial - pathology</subject><subject>Female</subject><subject>Gastroesophageal Reflux - diagnosis</subject><subject>Hamartoma - pathology</subject><subject>Humans</subject><subject>Hypothalamic Neoplasms - pathology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Seizures</subject><issn>0009-9228</issn><issn>1938-2707</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9LAzEQhYMotlbvnmRP3lYnyWazOZZaq1AR_HEOaXa2btl2a6YL6l9vSguCIJ7m8L73Bj7Gzjlcca71NQAYI0QBuTAqAzhgfW5kkQoN-pD1t3G6zXvshGgBwCUoecx6XGdaGQN9Npxg42hT--QZ668uICUPNZW1m69awjJxlExiHlqkdv3m5uia5AmrpvtIbmpCR3jKjirXEJ7t74C93o5fRnfp9HFyPxpOUy_zfJPqmVYQ__rSVZlHYYwSYAqtuSw0eJRcSBRcuVwhaCdMkXvUAsFzVYlKyQG73O2uQ_veIW3ssiaPTeNW2HZkNWTK8Dz7FxQgJC9MEUHYgT60RAEruw710oVPy8Fu_drffmPlYr_dzZZY_hT2QiOQ7gCKruyi7cIqSvl78BugJYCW</recordid><startdate>200705</startdate><enddate>200705</enddate><creator>Sweetman, Laura L.</creator><creator>Ng, Yu-tze</creator><creator>Kerrigan, John F.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200705</creationdate><title>Gelastic Seizures Misdiagnosed as Gastroesophageal Reflux Disease</title><author>Sweetman, Laura L. ; Ng, Yu-tze ; Kerrigan, John F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-7b750174cdaf4ce299520987713870ce3123e215a65e07a2986ce72e0c15f2f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Diagnosis, Differential</topic><topic>Diagnostic Errors</topic><topic>Epilepsies, Partial - pathology</topic><topic>Female</topic><topic>Gastroesophageal Reflux - diagnosis</topic><topic>Hamartoma - pathology</topic><topic>Humans</topic><topic>Hypothalamic Neoplasms - pathology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Seizures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sweetman, Laura L.</creatorcontrib><creatorcontrib>Ng, Yu-tze</creatorcontrib><creatorcontrib>Kerrigan, John F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sweetman, Laura L.</au><au>Ng, Yu-tze</au><au>Kerrigan, John F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gelastic Seizures Misdiagnosed as Gastroesophageal Reflux Disease</atitle><jtitle>Clinical pediatrics</jtitle><addtitle>Clin Pediatr (Phila)</addtitle><date>2007-05</date><risdate>2007</risdate><volume>46</volume><issue>4</issue><spage>325</spage><epage>328</epage><pages>325-328</pages><issn>0009-9228</issn><eissn>1938-2707</eissn><abstract>Gastroesophageal reflux disease can have variable manifestations including regurgitation, irritability, arching, choking, and apnea. The disorder is also frequently mistaken for seizures (Sandifer syndrome). We report 6 patients in whom the opposite phenomenon occurred: their seizures were mistaken for gastroesophageal reflux disease. Six of 77 patients (6.8%) with gelastic seizures and epilepsy symptomatic of hypothalamic hamartomas were noted to be misdiagnosed with gastroesophageal reflux disease in infancy. As is typical in these patients, gelastic seizures were not diagnosed until months, or often years, later. Delayed diagnosis of hypothalamic hamartomas can lead to a potentially deleterious syndrome involving refractory epilepsy, developmental problems, and precocious puberty. Gelastic seizures should be considered among the conditions that can mimic reflux symptoms.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>17475990</pmid><doi>10.1177/0009922806295400</doi><tpages>4</tpages></addata></record> |
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| subjects | Diagnosis, Differential Diagnostic Errors Epilepsies, Partial - pathology Female Gastroesophageal Reflux - diagnosis Hamartoma - pathology Humans Hypothalamic Neoplasms - pathology Infant Infant, Newborn Male Seizures |
| title | Gelastic Seizures Misdiagnosed as Gastroesophageal Reflux Disease |
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